Chris B. Schaffer

All-optical histology using ultrashort laser pulses.

Two-photon imaging of cortical surface microvessels reveals a robust redistribution in blood flow after vascular occlusion.

Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: three models of stroke.

Ablation of cytoskeletal filaments and mitochondria in live cells using a femtosecond laser nanoscissor.

Spectroscopic analysis of the oxygenation state of hemoglobin using coherent anti-Stokes Raman scattering.

Penetrating arterioles are a bottleneck in the perfusion of neocortex.

Large two-photon absorptivity of hemoglobin in the infrared range of 780-880 nm.

Flexible microfluidic devices supported by biodegradable insertion scaffolds for convection-enhanced neural drug delivery.

Photonic band-gap fiber gas cell fabricated using femtosecond micromachining.

Deep tissue multiphoton microscopy using longer wavelength excitation.

Two-photon microscopy-guided femtosecond-laser photoablation of avian cardiogenesis: noninvasive creation of localized heart defects.

Limitations of collateral flow after occlusion of a single cortical penetrating arteriole.

Optical tools to produce and study small strokes in animal models.

In vivo imaging of myelin in the vertebrate central nervous system using third harmonic generation microscopy.

Optically quantified cerebral blood flow.

Sub-surface, micrometer-scale incisions produced in rodent cortex using tightly-focused femtosecond laser pulses.

Occlusion of cortical ascending venules causes blood flow decreases, reversals in flow direction, and vessel dilation in upstream capillaries.

Anticoagulation with the oral direct thrombin inhibitor dabigatran does not enlarge hematoma volume in experimental intracerebral hemorrhage.

Preictal and ictal neurovascular and metabolic coupling surrounding a seizure focus.

Real-time imaging of perivascular transport of nanoparticles during convection-enhanced delivery in the rat cortex.

Cortical microhemorrhages cause local inflammation but do not trigger widespread dendrite degeneration.

Age-related intimal stiffening enhances endothelial permeability and leukocyte transmigration.

Estimating brain microvascular blood flows from partial two-photon microscopy data by computation with a circuit model.

Notch4 normalization reduces blood vessel size in arteriovenous malformations.

Chronic in vivo imaging in the mouse spinal cord using an implanted chamber.

In vivo two-photon excited fluorescence microscopy reveals cardiac- and respiration-dependent pulsatile blood flow in cortical blood vessels in mice.

Cyclic strain anisotropy regulates valvular interstitial cell phenotype and tissue remodeling in three-dimensional culture.

Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brain.

Line-scanning particle image velocimetry: an optical approach for quantifying a wide range of blood flow speeds in live animals.

Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice.

Intracerebral haemorrhage associated with antithrombotic treatment: translational insights from experimental studies.

Big effects from tiny vessels: imaging the impact of microvascular clots and hemorrhages on the brain.

Stimulus-evoked calcium transients in somatosensory cortex are temporarily inhibited by a nearby microhemorrhage.

Optoporation and genetic manipulation of cells using femtosecond laser pulses.

The challenge of connecting the dots in the B.R.a.I.N.

Optically induced occlusion of single blood vessels in rodent neocortex.

In vivo three-photon microscopy of subcortical structures within an intact mouse brain.

TRAIL-coated leukocytes that kill cancer cells in the circulation.

Growth and hemodynamics after early embryonic aortic arch occlusion.