Olivier Elemento

Reconstructing the duplication history of tandemly repeated genes.

An efficient and accurate distance based algorithm to reconstruct tandem duplication trees.

IMGT/PhyloGene: an on-line tool for comparative analysis of immunoglobulin and T cell receptor genes.

Fast and systematic genome-wide discovery of conserved regulatory elements using a non-alignment based approach.

Revealing posttranscriptional regulatory elements through network-level conservation.

Ab initio genotype-phenotype association reveals intrinsic modularity in genetic networks.

Unmasking activation of the zygotic genome using chromosomal deletions in the Drosophila embryo.

Developing a systems-level understanding of gene expression.

A universal framework for regulatory element discovery across all genomes and data types.

Fastcompare: a nonalignment approach for genome-scale discovery of DNA and mRNA regulatory elements using network-level conservation.

let-7 Overexpression leads to an increased fraction of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblasts.

The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL.

Coupling of zygotic transcription to mitotic control at the Drosophila mid-blastula transition.

DISPARE: DIScriminative PAttern REfinement for Position Weight Matrices.

Revealing global regulatory perturbations across human cancers.

DNA methylation signatures define molecular subtypes of diffuse large B-cell lymphoma.

EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis.

Identification and genome-wide prediction of DNA binding specificities for the ApiAP2 family of regulators from the malaria parasite.

Mutations in FLVCR1 cause posterior column ataxia and retinitis pigmentosa.

Large-scale discovery and characterization of protein regulatory motifs in eukaryotes.

An integrated ChIP-seq analysis platform with customizable workflows.

DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation.

Using transcriptome sequencing to identify mechanisms of drug action and resistance.

A panel of four miRNAs accurately differentiates malignant from benign indeterminate thyroid lesions on fine needle aspiration.

Faster sequencers, larger datasets, new challenges.

Calcimimetics versus parathyroidectomy for treatment of primary hyperparathyroidism: retrospective chart analysis of a prospective database.

Identification of functionally active, low frequency copy number variants at 15q21.3 and 12q21.31 associated with prostate cancer risk.

Concordant signaling pathways produced by pesticide exposure in mice correspond to pathways identified in human Parkinson's disease.

Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.

Oncogene-mediated alterations in chromatin conformation.

Genome-wide detection of genes targeted by non-Ig somatic hypermutation in lymphoma.

Oncogenic transcription factors as master regulators of chromatin topology: a new role for ERG in prostate cancer.

Efficient direct reprogramming of mature amniotic cells into endothelial cells by ETS factors and TGFβ suppression.

Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia.

Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition.

Antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis.

Epigenetic repression of miR-31 disrupts androgen receptor homeostasis and contributes to prostate cancer progression.

Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity.

NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche.

Metabolic alterations in lung cancer-associated fibroblasts correlated with increased glycolytic metabolism of the tumor.

Inferring chromatin-bound protein complexes from genome-wide binding assays.

Epigenomic alterations in localized and advanced prostate cancer.

Downregulation of FOXP1 is required during germinal center B-cell function.

Punctuated evolution of prostate cancer genomes.

A novel approach for characterizing microsatellite instability in cancer cells.

EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation.

AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes.

A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis.

The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry.

Molecular signatures of tissue-specific microvascular endothelial cell heterogeneity in organ maintenance and regeneration.

A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.

Akt suppression of TGFβ signaling contributes to the maintenance of vascular identity in embryonic stem cell-derived endothelial cells.

Synergistic activation of inflammatory cytokine genes by interferon-γ-induced chromatin remodeling and toll-like receptor signaling.

EZH2 mutations are frequent and represent an early event in follicular lymphoma.

Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis.

Molecular diagnosis of autosomal dominant polycystic kidney disease using next-generation sequencing.

Double-stranded DNA in exosomes: a novel biomarker in cancer detection.

Histone variant H3.3 is an essential maternal factor for oocyte reprogramming.

Silencing of UCHL1 by CpG promoter hyper-methylation is associated with metastatic gastroenteropancreatic well-differentiated neuroendocrine (carcinoid) tumors.

DrugTargetSeqR: a genomics- and CRISPR-Cas9-based method to analyze drug targets.

Impact of ERBB2 mutations on in vitro sensitivity of bladder cancer to lapatinib.

Reprogramming human endothelial cells to haematopoietic cells requires vascular induction.

Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphoma.

Deep sequencing reveals clonal evolution patterns and mutation events associated with relapse in B-cell lymphomas.

Tracing the roots of cancer evolution.

Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation.

Tbx5 is required for avian and Mammalian epicardial formation and coronary vasculogenesis.

Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony-forming cells.

The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer.

ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis.

Dicer expression and microRNA dysregulation associate with aggressive features in thyroid cancer.

Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells.

Lymphoblastic transformation of follicular lymphoma: a clinicopathologic and molecular analysis of 7 patients.

ELAVL1 modulates transcriptome-wide miRNA binding in murine macrophages.

Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells.

Transcriptome analysis of individual stromal cell populations identifies stroma-tumor crosstalk in mouse lung cancer model.

Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation.

The BRAF pseudogene functions as a competitive endogenous RNA and induces lymphoma in vivo.

Epigenomic evolution in diffuse large B-cell lymphomas.

The chromatin Remodeler CHD8 is required for activation of progesterone receptor-dependent enhancers.

CCMCL1: a new model of aggressive mantle cell lymphoma.

Integrative clinical genomics of advanced prostate cancer.

Identification of Reprogrammed Myeloid Cell Transcriptomes in NSCLC.

A primer on precision medicine informatics.

Mechanosensitive pannexin-1 channels mediate microvascular metastatic cell survival.

Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia.

Use of RNA sequencing to evaluate rheumatic disease patients.

Whole-Exome Sequencing of Metastatic Cancer and Biomarkers of Treatment Response.

Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis.

DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID.

The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.

Vascular Platform to Define Hematopoietic Stem Cell Factors and Enhance Regenerative Hematopoiesis.

Transcriptome sequencing reveals thousands of novel long non-coding RNAs in B cell lymphoma.

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.

Prediction of Genetic Interactions Using Machine Learning and Network Properties.

5' UTR m(6)A Promotes Cap-Independent Translation.

Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas.

Prostate-Specific Membrane Antigen Is a Potential Antiangiogenic Target in Adrenocortical Carcinoma.

Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer.

Nuclear envelope expansion is crucial for proper chromosomal segregation during a closed mitosis.

Practical Analysis of Genome Contact Interaction Experiments.

Predictive features of ligand-specific signaling through the estrogen receptor.

Epigenetic profiles signify cell fate plasticity in unipotent spermatogonial stem and progenitor cells.

Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance.

A Computational Drug Repositioning Approach for Targeting Oncogenic Transcription Factors.

Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer.

Single-cell TCRseq: paired recovery of entire T-cell alpha and beta chain transcripts in T-cell receptors from single-cell RNAseq.

Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma.

KLF4: A new player in plasma cell development.

EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis.

Deep Sequencing of T-cell Receptor DNA as a Biomarker of Clonally Expanded TILs in Breast Cancer after Immunotherapy.

An Epigenomic Approach to Improving Response to Neoadjuvant Cisplatin Chemotherapy in Bladder Cancer.

Discovery and clinical introduction of first-in-class imipridone ONC201.

Multi-tiered Reorganization of the Genome during B Cell Affinity Maturation Anchored by a Germinal Center-Specific Locus Control Region.

A Data-Driven Approach to Predicting Successes and Failures of Clinical Trials.

N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer.

CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.

Clonal evolution of chemotherapy-resistant urothelial carcinoma.

The cancer precision medicine knowledge base for structured clinical-grade mutations and interpretations.

Therapeutic efficacy of the bromodomain inhibitor OTX015/MK-8628 in ALK-positive anaplastic large cell lymphoma: an alternative modality to overcome resistant phenotypes.

Systematic Discovery of Chromatin-Bound Protein Complexes from ChIP-seq Datasets.

Mechanisms of Acquired Drug Resistance to the HDAC6 Selective Inhibitor Ricolinostat Reveals Rational Drug-Drug Combination with Ibrutinib.

Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis.

Reversible methylation of m(6)Am in the 5' cap controls mRNA stability.

Role of RPL39 in Metaplastic Breast Cancer.

Systems Structural Biology Analysis of Ligand Effects on ERα Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.

A Computational Approach for Identifying Synergistic Drug Combinations.

Sox17 drives functional engraftment of endothelium converted from non-vascular cells.

Regulatory elements in molecular networks.

Effective Combination Therapies for B-cell Lymphoma Predicted by a Virtual Disease Model.

Melanoma genome evolution across species.

BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells.

Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Anti-Tumor Innate Immunity.

Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine.

Oncogenic BRAF disrupts thyroid morphogenesis and function via twist expression.

EthSEQ: ethnicity annotation from whole exome sequencing data.

Epigenetic Identity in AML Depends on Disruption of Non-promoter Regulatory Elements and is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers.

Stem Cell Lineage Infidelity Drives Wound Repair and Cancer.

Global miRNA expression analysis identifies novel key regulators of plasma cell differentiation and malignant plasma cell.

Identification of a nucleoside analog active against adenosine kinase-expressing plasma cell malignancies.

An integrated model for detecting significant chromatin interactions from high-resolution Hi-C data.

Conversion of adult endothelium to immunocompetent haematopoietic stem cells.

Widespread Mitotic Bookmarking by Histone Marks and Transcription Factors in Pluripotent Stem Cells.

Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors.

Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells.