Unité de Génétique et Biologie du Développement
Edith Heard has not added Biography.
If you are Edith Heard and would like to personalize this page please email our Author Liaison for assistance.
Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes.
Nature genetics Jan, 2002 | Pubmed ID: 11740495
Antisense RNA in imprinting: spreading silence through Air.
Trends in genetics : TIG Sep, 2002 | Pubmed ID: 12175797
Relationship of XIST expression and responses of ovarian cancer to chemotherapy.
Molecular cancer therapeutics Aug, 2002 | Pubmed ID: 12492109
Role of histone methyltransferase G9a in CpG methylation of the Prader-Willi syndrome imprinting center.
The Journal of biological chemistry Apr, 2003 | Pubmed ID: 12586828
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.
Cell Jun, 2003 | Pubmed ID: 12809602
Epigenetic dynamics of imprinted X inactivation during early mouse development.
Science (New York, N.Y.) Jan, 2004 | Pubmed ID: 14671313
X-chromosome inactivation in mouse embryonic stem cells: analysis of histone modifications and transcriptional activity using immunofluorescence and FISH.
Methods in enzymology , 2004 | Pubmed ID: 14975321
Recent advances in X-chromosome inactivation.
Current opinion in cell biology Jun, 2004 | Pubmed ID: 15145348
Differential histone H3 Lys-9 and Lys-27 methylation profiles on the X chromosome.
Molecular and cellular biology Jun, 2004 | Pubmed ID: 15169908
Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts.
Development (Cambridge, England) Apr, 2005 | Pubmed ID: 15753215
Initiation of epigenetic reprogramming of the X chromosome in somatic nuclei transplanted to a mouse oocyte.
EMBO reports Aug, 2005 | Pubmed ID: 16007070
Delving into the diversity of facultative heterochromatin: the epigenetics of the inactive X chromosome.
Current opinion in genetics & development Oct, 2005 | Pubmed ID: 16107314
Evidence for de novo imprinted X-chromosome inactivation independent of meiotic inactivation in mice.
Nature Nov, 2005 | Pubmed ID: 16227973
Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation.
Nature cell biology Mar, 2006 | Pubmed ID: 16434960
Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin.
Molecular and cellular biology Apr, 2006 | Pubmed ID: 16537902
Dosage compensation in mammals: fine-tuning the expression of the X chromosome.
Genes & development Jul, 2006 | Pubmed ID: 16847345
A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced.
Genes & development Aug, 2006 | Pubmed ID: 16912274
[Cross talk between the Xics].
Médecine sciences : M/S Nov, 2006 | Pubmed ID: 17101084
Non-rigid registration of 3D multi-channel microscopy images of cell nuclei.
Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention , 2006 | Pubmed ID: 17354977
The ins and outs of gene regulation and chromosome territory organisation.
Current opinion in cell biology Jun, 2007 | Pubmed ID: 17467967
X inactive-specific transcript RNA coating and genetic instability of the X chromosome in BRCA1 breast tumors.
Cancer research Jun, 2007 | Pubmed ID: 17545591
A phosphorylated subpopulation of the histone variant macroH2A1 is excluded from the inactive X chromosome and enriched during mitosis.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2008 | Pubmed ID: 18227505
Chromosome structural proteins and RNA-mediated epigenetic silencing.
Developmental cell Jun, 2008 | Pubmed ID: 18539109
[Inactivation of X chromosome: cells know how to count two X chromosomes].
Médecine sciences : M/S Jun-Jul, 2008 | Pubmed ID: 18601875
Combined immunofluorescence, RNA fluorescent in situ hybridization, and DNA fluorescent in situ hybridization to study chromatin changes, transcriptional activity, nuclear organization, and X-chromosome inactivation.
Methods in molecular biology (Clifton, N.J.) , 2008 | Pubmed ID: 18951174
Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development.
Molecular and cellular biology Apr, 2009 | Pubmed ID: 19223465
Dynamic changes in paternal X-chromosome activity during imprinted X-chromosome inactivation in mice.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2009 | Pubmed ID: 19273861
X inactivation and the complexities of silencing a sex chromosome.
Current opinion in cell biology Jun, 2009 | Pubmed ID: 19477626
High-resolution analysis of epigenetic changes associated with X inactivation.
Genome research Aug, 2009 | Pubmed ID: 19581487
Highly dynamic and sex-specific expression of microRNAs during early ES cell differentiation.
PLoS genetics Aug, 2009 | Pubmed ID: 19714213
Foreword: Coping with sex chromosome imbalance.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology , 2009 | Pubmed ID: 19760092
Lessons from comparative analysis of X-chromosome inactivation in mammals.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology , 2009 | Pubmed ID: 19802706
X chromosome inactivation: when dosage counts.
Cell Nov, 2009 | Pubmed ID: 19945374
Epigenetic mechanisms in development and disease.
Seminars in cell & developmental biology Apr, 2010 | Pubmed ID: 20079450
LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation.
Cell Jun, 2010 | Pubmed ID: 20550932
Dynamic plasticity of large-scale chromatin structure revealed by self-assembly of engineered chromosome regions.
The Journal of cell biology Sep, 2010 | Pubmed ID: 20819934
Ten years of genetics and genomics: what have we achieved and where are we heading?
Nature reviews. Genetics Oct, 2010 | Pubmed ID: 20820184
Girafe--an R/Bioconductor package for functional exploration of aligned next-generation sequencing reads.
Bioinformatics (Oxford, England) Nov, 2010 | Pubmed ID: 20861030
Nuclear organization and dosage compensation.
Cold Spring Harbor perspectives in biology Nov, 2010 | Pubmed ID: 20943757
[Establishing transcriptional silencing of the X chromosome during early embryogenesis].
Biologie aujourd'hui , 2010 | Pubmed ID: 20950563
Rnf12--a jack of all trades in X inactivation?
PLoS genetics , 2011 | Pubmed ID: 21298029
Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development.
Nature Apr, 2011 | Pubmed ID: 21471966
Live-cell chromosome dynamics and outcome of X chromosome pairing events during ES cell differentiation.
Cell Apr, 2011 | Pubmed ID: 21529716
Regulation of X-chromosome inactivation by the X-inactivation centre.
Nature reviews. Genetics Jun, 2011 | Pubmed ID: 21587299
Evolutionary diversity and developmental regulation of X-chromosome inactivation.
Human genetics Aug, 2011 | Pubmed ID: 21687993
The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA.
Genes & development Jul, 2011 | Pubmed ID: 21690198
Function of the sex chromosomes in mammalian fertility.
Cold Spring Harbor perspectives in biology Oct, 2011 | Pubmed ID: 21730045
Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
PloS one , 2011 | Pubmed ID: 21731673
Fifty years of X-inactivation research.
Development (Cambridge, England) Dec, 2011 | Pubmed ID: 22069183
Naive and primed murine pluripotent stem cells have distinct miRNA expression profiles.
RNA (New York, N.Y.) Feb, 2012 | Pubmed ID: 22201644
MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation.
Cell stem cell Jan, 2012 | Pubmed ID: 22226354
Deep-sequencing protocols influence the results obtained in small-RNA sequencing.
PloS one , 2012 | Pubmed ID: 22384282
Spatial partitioning of the regulatory landscape of the X-inactivation centre.
Nature May, 2012 | Pubmed ID: 22495304
Smchd1-dependent and -independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome.
Developmental cell Aug, 2012 | Pubmed ID: 22841499
HiTC: exploration of high-throughput 'C' experiments.
Bioinformatics (Oxford, England) Nov, 2012 | Pubmed ID: 22923296
ncPRO-seq: a tool for annotation and profiling of ncRNAs in sRNA-seq data.
Bioinformatics (Oxford, England) Dec, 2012 | Pubmed ID: 23044543
Recent advances in X-chromosome inactivation research.
Current opinion in cell biology Dec, 2012 | Pubmed ID: 23142477
Unusual chromatin status and organization of the inactive X chromosome in murine trophoblast giant cells.
Development (Cambridge, England) Feb, 2013 | Pubmed ID: 23362347
Role and control of X chromosome dosage in mammalian development.
Current opinion in genetics & development Apr, 2013 | Pubmed ID: 23465885
The dynamics of epigenetic changes in a range of organisms.
Current topics in developmental biology , 2013 | Pubmed ID: 23587246
Small RNAs derived from structural non-coding RNAs.
Methods (San Diego, Calif.) Sep, 2013 | Pubmed ID: 23684746
Cell nucleus.
Current opinion in cell biology Jun, 2013 | Pubmed ID: 23746906
Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes.
Molecular and cellular biology Aug, 2013 | Pubmed ID: 23754746
Segmental folding of chromosomes: a basis for structural and regulatory chromosomal neighborhoods?
BioEssays : news and reviews in molecular, cellular and developmental biology Sep, 2013 | Pubmed ID: 23832846
The pluripotent genome in three dimensions is shaped around pluripotency factors.
Nature Sep, 2013 | Pubmed ID: 23883933
Live-cell imaging combined with immunofluorescence, RNA, or DNA FISH to study the nuclear dynamics and expression of the X-inactivation center.
Methods in molecular biology (Clifton, N.J.) , 2013 | Pubmed ID: 23979997
Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments.
Genome research Dec, 2013 | Pubmed ID: 24002784
RNAi-dependent and independent control of LINE1 accumulation and mobility in mouse embryonic stem cells.
PLoS genetics Nov, 2013 | Pubmed ID: 24244175
Changes in the organization of the genome during the mammalian cell cycle.
Genome biology , 2013 | Pubmed ID: 24368000
Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome.
Molecular cell Jan, 2014 | Pubmed ID: 24462204
The two active X chromosomes in female ESCs block exit from the pluripotent state by modulating the ESC signaling network.
Cell stem cell Feb, 2014 | Pubmed ID: 24506884
Developmental dynamics and disease potential of random monoallelic gene expression.
Developmental cell Feb, 2014 | Pubmed ID: 24576422
Transgenerational epigenetic inheritance: myths and mechanisms.
Cell Mar, 2014 | Pubmed ID: 24679529
Predictive polymer modeling reveals coupled fluctuations in chromosome conformation and transcription.
Cell May, 2014 | Pubmed ID: 24813616
MOF-associated complexes ensure stem cell identity and Xist repression.
eLife , 2014 | Pubmed ID: 24842875
X-chromosome inactivation in development and cancer.
FEBS letters Aug, 2014 | Pubmed ID: 24937141
Noncoding RNAs and epigenetic mechanisms during X-chromosome inactivation.
Annual review of cell and developmental biology , 2014 | Pubmed ID: 25000994
[Initiation of X chromosome inactivation during early embryogenesis in mice and in humans].
Bulletin de l'Académie nationale de médecine Mar, 2013 | Pubmed ID: 25163344
High-resolution 3D DNA FISH using plasmid probes and computational correction of optical aberrations to study chromatin structure at the sub-megabase scale.
Methods in molecular biology (Clifton, N.J.) , 2015 | Pubmed ID: 25555574
Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.
Molecular cell Mar, 2015 | Pubmed ID: 25620564
The inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer.
Genome research Apr, 2015 | Pubmed ID: 25653311
Systematic discovery of Xist RNA binding proteins.
Cell Apr, 2015 | Pubmed ID: 25843628
Correction: RNAi-Dependent and Independent Control of LINE1 Accumulation and Mobility in Mouse Embryonic Stem Cells.
PLoS genetics May, 2015 | Pubmed ID: 25973973
X-chromosome inactivation: new insights into cis and trans regulation.
Current opinion in genetics & development Apr, 2015 | Pubmed ID: 26004255
[The legacy of Mary F. Lyon (1925-2014)].
Médecine sciences : M/S Jun-Jul, 2015 | Pubmed ID: 26152175
Structural and functional diversity of Topologically Associating Domains.
FEBS letters Oct, 2015 | Pubmed ID: 26348399
HiC-Pro: an optimized and flexible pipeline for Hi-C data processing.
Genome biology , 2015 | Pubmed ID: 26619908
Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation.
eLife , 2016 | Pubmed ID: 26836306
Structural Fluctuations of the Chromatin Fiber within Topologically Associating Domains.
Biophysical journal Mar, 2016 | Pubmed ID: 27028634
Random monoallelic expression of genes on autosomes: Parallels with X-chromosome inactivation.
Seminars in cell & developmental biology Aug, 2016 | Pubmed ID: 27101886
Structural organization of the inactive X chromosome in the mouse.
Nature Jul, 2016 | Pubmed ID: 27437574
LINE-1 Activity in Facultative Heterochromatin Formation during X Chromosome Inactivation.
Cell Jul, 2016 | Pubmed ID: 27471971
Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogramming.
Nature communications , 2016 | Pubmed ID: 27507283
Genomes of Ellobius species provide insight into the evolutionary dynamics of mammalian sex chromosomes.
Genome research Aug, 2016 | Pubmed ID: 27510564
A symmetric toggle switch explains the onset of random X inactivation in different mammals.
Nature structural & molecular biology 05, 2019 | Pubmed ID: 30962582
Advances in epigenetics link genetics to the environment and disease.
Nature 07, 2019 | Pubmed ID: 31341302
Xist RNA in action: Past, present, and future.
PLoS genetics 09, 2019 | Pubmed ID: 31537017
A Conserved Noncoding Locus Regulates Random Monoallelic Xist Expression across a Topological Boundary.
Molecular cell 01, 2020 | Pubmed ID: 31759823
SPEN integrates transcriptional and epigenetic control of X-inactivation.
Nature 02, 2020 | Pubmed ID: 32025035
Parental-to-embryo switch of chromosome organization in early embryogenesis.
Nature 04, 2020 | Pubmed ID: 32238933
Locus specific epigenetic modalities of random allelic expression imbalance.
Nature communications 09, 2021 | Pubmed ID: 34504093
Noncoding RNAs: biology and applications-a Keystone Symposia report.
Annals of the New York Academy of Sciences 12, 2021 | Pubmed ID: 34791665
Gene regulation in time and space during X-chromosome inactivation.
Nature reviews. Molecular cell biology 04, 2022 | Pubmed ID: 35013589
The X chromosome from telomere to telomere: key achievements and future opportunities.
Faculty reviews , 2021 | Pubmed ID: 35088059
Molecular biology for green recovery-A call for action.
PLoS biology 04, 2022 | Pubmed ID: 35452449
XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation.
Cell 06, 2022 | Pubmed ID: 35597241
关于 JoVE
版权所属 © 2024 MyJoVE 公司版权所有,本公司不涉及任何医疗业务和医疗服务。