Department of Biomedical Engineering and Cardiac Bioelectricity and Arrhythmia Center
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Mechanism of magnesium activation of calcium-activated potassium channels.
Nature Aug, 2002 | Pubmed ID: 12192410
Participation of the S4 voltage sensor in the Mg2+-dependent activation of large conductance (BK) K+ channels.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2003 | Pubmed ID: 12925732
Ultrasound-induced cell membrane porosity.
Ultrasound in medicine & biology Apr, 2004 | Pubmed ID: 15121254
Assembly of a Ca2+-dependent BK channel signaling complex by binding to beta2 adrenergic receptor.
The EMBO journal Jun, 2004 | Pubmed ID: 15141163
Identification of a KCNE2 gain-of-function mutation in patients with familial atrial fibrillation.
American journal of human genetics Nov, 2004 | Pubmed ID: 15368194
Study of sonoporation dynamics affected by ultrasound duty cycle.
Ultrasound in medicine & biology Jun, 2005 | Pubmed ID: 15936500
Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder.
Nature genetics Jul, 2005 | Pubmed ID: 15937479
The NH2 terminus of RCK1 domain regulates Ca2+-dependent BK(Ca) channel gating.
The Journal of general physiology Sep, 2005 | Pubmed ID: 16103277
Effects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channels.
The Journal of general physiology Jan, 2006 | Pubmed ID: 16344323
Tuning magnesium sensitivity of BK channels by mutations.
Biophysical journal Oct, 2006 | Pubmed ID: 16877509
Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channels.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2007 | Pubmed ID: 17984060
Effects of extracellular calcium on cell membrane resealing in sonoporation.
Journal of controlled release : official journal of the Controlled Release Society Feb, 2008 | Pubmed ID: 18158198
Dynamics of sonoporation correlated with acoustic cavitation activities.
Biophysical journal Apr, 2008 | Pubmed ID: 18212008
Subunit-specific effect of the voltage sensor domain on Ca2+ sensitivity of BK channels.
Biophysical journal Jun, 2008 | Pubmed ID: 18339745
Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains.
Nature structural & molecular biology Nov, 2008 | Pubmed ID: 18931675
{beta} subunit-specific modulations of BK channel function by a mutation associated with epilepsy and dyskinesia.
The Journal of physiology Apr, 2009 | Pubmed ID: 19204046
A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2009 | Pubmed ID: 19549851
The size of sonoporation pores on the cell membrane.
Ultrasound in medicine & biology Oct, 2009 | Pubmed ID: 19647924
Reduction of CaV channel activities by Ca2+-CaM: inactivation or deactivation?
The Journal of general physiology Apr, 2010 | Pubmed ID: 20194603
State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation.
The Journal of general physiology Jun, 2010 | Pubmed ID: 20479111
beta2- but not beta1-adrenoceptor activation modulates intracellular oxygen availability.
The Journal of physiology Aug, 2010 | Pubmed ID: 20547682
An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing.
Neuron Jun, 2010 | Pubmed ID: 20620873
BK-type calcium-activated potassium channels: coupling of metal ions and voltage sensing.
The Journal of physiology Dec, 2010 | Pubmed ID: 20660558
BK channel activation: structural and functional insights.
Trends in neurosciences Sep, 2010 | Pubmed ID: 20663573
Ion sensing in the RCK1 domain of BK channels.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2010 | Pubmed ID: 20937866
KCNE1 remodels the voltage sensor of Kv7.1 to modulate channel function.
Biophysical journal Dec, 2010 | Pubmed ID: 21112284
Modulation of BK channel gating by the ß2 subunit involves both membrane-spanning and cytoplasmic domains of Slo1.
The Journal of neuroscience : the official journal of the Society for Neuroscience Dec, 2010 | Pubmed ID: 21123563
Prolyl hydroxylase 2: a novel regulator of β2 -adrenoceptor internalization.
Journal of cellular and molecular medicine Dec, 2011 | Pubmed ID: 21255264
KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activity.
Proceedings of the National Academy of Sciences of the United States of America May, 2011 | Pubmed ID: 21576493
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