David K Cole

Basis for fusion inhibition by peptides: analysis of the heptad repeat regions of the fusion proteins from Nipah and Hendra viruses, newly emergent zoonotic paramyxoviruses.

Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors.

Crystallization and preliminary crystallographic analysis of the fusion core from two new zoonotic paramyxoviruses, Nipah virus and Hendra virus.

SARS coronavirus induces apoptosis in Vero E6 cells.

Complex assembly, crystallization and preliminary X-ray crystallographic studies of MHC H-2Kd complexed with an HBV-core nonapeptide.

Biochemical, biophysical and preliminary X-ray crystallographic analyses of the fusion core of Sendai virus F protein.

Construct design, biophysical, and biochemical characterization of the fusion core from mouse hepatitis virus (a coronavirus) spike protein.

Characterization of the heptad repeat regions, HR1 and HR2, and design of a fusion core structure model of the spike protein from severe acute respiratory syndrome (SARS) coronavirus.

CD8: adhesion molecule, co-receptor and immuno-modulator.

Crystal structure of HLA-A*2402 complexed with a telomerase peptide.

Crystallization and preliminary X-ray structural studies of a high-affinity CD8alphaalpha co-receptor to pMHC.

Computational design and crystal structure of an enhanced affinity mutant human CD8 alphaalpha coreceptor.

Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor.

Human TCR-binding affinity is governed by MHC class restriction.

Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotoxic T lymphocyte activation and tetramer binding properties.

T cell receptor engagement of peptide-major histocompatibility complex class I does not modify CD8 binding.

Detection of low avidity CD8(+) T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers.

Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor.

Tricks with tetramers: how to get the most from multimeric peptide-MHC.

Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor.

Peptide-major histocompatibility complex dimensions control proximal kinase-phosphatase balance during T cell activation.

ELISPOT and functional T cell analyses using HLA mono-specific target cells.

T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility.

MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.

Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition.

Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection.

Real time detection of peptide-MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability.

Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining.

Correlation of in situ mechanosensitive responses of the Moraxella catarrhalis adhesin UspA1 with fibronectin and receptor CEACAM1 binding.

The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells.

Structural and biophysical determinants of αβ T-cell antigen recognition.

Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.

Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4⁺ T-cell repertoire selection.

TCR/pMHC Optimized Protein crystallization Screen.

The molecular determinants of CD8 co-receptor function.

Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity.

T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting.

Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers.

Peptide length determines the outcome of TCR/peptide-MHCI engagement.

T-cell receptor specificity maintained by altered thermodynamics.

Increased Peptide Contacts Govern High Affinity Binding of a Modified TCR Whilst Maintaining a Native pMHC Docking Mode.

Re-Directing CD4(+) T Cell Responses with the Flanking Residues of MHC Class II-Bound Peptides: The Core is Not Enough.

Cellular-level versus receptor-level response threshold hierarchies in T-cell activation.

T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions.

The versatility of the αβ T-cell antigen receptor.

Molecular basis of a dominant T cell response to an HIV reverse transcriptase 8-mer epitope presented by the protective allele HLA-B*51:01.

Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance.

Recurrence of melanoma following T cell treatment: continued antigen expression in a tumor that evades T cell recruitment.

Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs.

Structural basis for ineffective T-cell responses to MHC anchor residue-improved "heteroclitic" peptides.

Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics.

A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape.

The ultimate mix and match: making sense of HLA alleles and peptide repertoires.

The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy.

More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers.

Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide.

Enhanced Detection of Antigen-Specific CD4+ T Cells Using Altered Peptide Flanking Residue Peptide-MHC Class II Multimers.

Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.

T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones.

A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen.

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.

Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.