Mark Helm

Variability of Substrate Specificity of Serum Antibodies Obtained from Patients with Different Autoimmune and Viral Diseases in Reaction of tRNA Hydrolysis.

RNA sex.

A monomer-to-trimer transition of the human mitochondrial transcription termination factor (mTERF) is associated with a loss of in vitro activity.

Nuclear control of cloverleaf structure of human mitochondrial tRNA(Lys).

Aminoacylation properties of pathology-related human mitochondrial tRNA(Lys) variants.

Allosterically activated Diels-Alder catalysis by a ribozyme.

A new mechanism for mtDNA pathogenesis: impairment of post-transcriptional maturation leads to severe depletion of mitochondrial tRNASer(UCN) caused by T7512C and G7497A point mutations.

Optimizing splinted ligation of highly structured small RNAs.

Post-transcriptional nucleotide modification and alternative folding of RNA.

Molecular dysfunction associated with the human mitochondrial 3302A>G mutation in the MTTL1 (mt-tRNALeu(UUR)) gene.

Mg2+-dependent folding of a Diels-Alderase ribozyme probed by single-molecule FRET analysis.

Surveillance of siRNA integrity by FRET imaging.

A methyl group controls conformational equilibrium in human mitochondrial tRNA(Lys).

Readout of micromechanical cantilever sensor arrays by Fabry-Perot interferometry.

Use of DNAzymes for site-specific analysis of ribonucleotide modifications.

Sculpting an RNA conformational energy landscape by a methyl group modification--a single-molecule FRET study.

Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism.

RNA intramolecular dynamics by single-molecule FRET.

An empirical basis for standardizing adherence measures derived from administrative claims data among diabetic patients.

Preparation of small amounts of sterile siRNA-liposomes with high entrapping efficiency by dual asymmetric centrifugation (DAC).

Prospective validation of eight different adherence measures for use with administrative claims data among patients with schizophrenia.

Effect of a quaternary pentamine on RNA stabilization and enzymatic methylation.

Good and poor adherence: optimal cut-point for adherence measures using administrative claims data.

In vivo down-regulation of mouse brain capillary P-glycoprotein: a preliminary investigation.

5-methylcytosine in RNA: detection, enzymatic formation and biological functions.

FRET imaging of cells transfected with siRNA/liposome complexes.

Formation of a stalled early intermediate of pseudouridine synthesis monitored by real-time FRET.

Evidence-based use of second-generation antipsychotics in a state Medicaid pediatric population, 2001-2005.

A new nuclear function of the Entamoeba histolytica glycolytic enzyme enolase: the metabolic regulation of cytosine-5 methyltransferase 2 (Dnmt2) activity.

Detection of RNA modifications.

tRNA stabilization by modified nucleotides.

RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage.

Expanding the chemical scope of RNA:methyltransferases to site-specific alkynylation of RNA for click labeling.

Measuring single small molecule binding via rupture forces of a split aptamer.

A post-labeling approach for the characterization and quantification of RNA modifications based on site-directed cleavage by DNAzymes.

Single-molecule FRET studies of counterion effects on the free energy landscape of human mitochondrial lysine tRNA.

A multifunctional bioconjugate module for versatile photoaffinity labeling and click chemistry of RNA.

Use of specific chemical reagents for detection of modified nucleotides in RNA.

Regulatory RNAs and beyond.

Single-molecule FRET reveals a cooperative effect of two methyl group modifications in the folding of human mitochondrial tRNA(Lys).

RNA nucleotide methylation.

Dye selection for live cell imaging of intact siRNA.

Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity.