Hans Bisgaard

Cesarean section and chronic immune disorders.

Leukotriene modifiers.

Systemic activity of inhaled steroids in 1- to 3-year-old children with asthma.

Maternal vaginal microflora during pregnancy and the risk of asthma hospitalization and use of antiasthma medication in early childhood.

Levalbuterol has not been established to have therapeutic advantage over racemic albuterol.

A randomized trial of montelukast in respiratory syncytial virus postbronchiolitis.

Effect of plastic spacer handling on salbutamol lung deposition in asthmatic children.

Effects of cysteinyl leukotrienes and leukotriene receptor antagonists on markers of inflammation.

Response to montelukast among subgroups of children aged 2 to 14 years with asthma.

Effect of long-acting beta2 agonists on exacerbation rates of asthma in children.

Comparisons of the complementary effect on exhaled nitric oxide of salmeterol vs montelukast in asthmatic children taking regular inhaled budesonide.

Montelukast and fluticasone compared with salmeterol and fluticasone in protecting against asthma exacerbation in adults: one year, double blind, randomised, comparative trial.

Twelve-month safety and efficacy of inhaled fluticasone propionate in children aged 1 to 3 years with recurrent wheezing.

Montelukast in RSV-bronchiolitis.

Serial lung function and responsiveness in cystic fibrosis during early childhood.

Variations in pediatric asthma hospitalization rates and costs between and within Nordic countries.

Yes, steroids are safe in infants with asthma-like symptoms.

Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma.

The Copenhagen Prospective Study on Asthma in Childhood (COPSAC): design, rationale, and baseline data from a longitudinal birth cohort study.

Montelukast reduces asthma exacerbations in 2- to 5-year-old children with intermittent asthma.

Hyperventilation with cold versus dry air in 2- to 5-year-old children with asthma.

Understanding mild persistent asthma in children: the next frontier.

Validation of a pediatric caregiver diary to measure symptoms of postacute respiratory syncytial virus bronchiolitis.

Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years.

Plethysmographic measurements of specific airway resistance in young children.

[No risk of development of osteoporosis or inhibition of growth in children with asthma treated with inhaled corticosteroids].

Exhaled nitric oxide predicts exercise-induced bronchoconstriction in asthmatic school children.

Cold air challenge and specific airway resistance in preschool children.

Long-acting beta2 agonists and paediatric asthma.

Sensitivity of bronchial responsiveness measurements in young infants.

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis.

Acute relief of exercise-induced bronchoconstriction by inhaled formoterol in children with persistent asthma.

Intermittent inhaled corticosteroids in infants with episodic wheezing.

Development of atopic dermatitis during the first 3 years of life: the Copenhagen prospective study on asthma in childhood cohort study in high-risk children.

Daily home measurements of exhaled nitric oxide in asthmatic children during natural birch pollen exposure.

Fatty acid composition of human milk in atopic Danish mothers.

Budesonide/formoterol maintenance plus reliever therapy: a new strategy in pediatric asthma.

Age dependent systemic exposure to inhaled salbutamol.

An official American Thoracic Society/European Respiratory Society statement: pulmonary function testing in preschool children.

Prevalence of asthma-like symptoms in young children.

What drives prescription patterns in pediatric asthma management?

Childhood asthma after bacterial colonization of the airway in neonates.

Feasibility of repetitive lung function measurements by raised volume rapid thoracoabdominal compression during methacholine challenge in young infants.

Increased concordance of severe respiratory syncytial virus infection in identical twins.

Extrapolating evidence beyond age groups.

Sensitization does not develop in utero.

Lung function and bronchial responsiveness after Mycoplasma pneumoniae infection in early childhood.

Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure.

Study of montelukast for the treatment of respiratory symptoms of post-respiratory syncytial virus bronchiolitis in children.

Early bioavailability of inhaled salbutamol reflects lung dose in children.

ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestry.

Classification of atopic hand eczema and the filaggrin mutations.

Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood.

Predicting an asthma exacerbation in children 2 to 5 years of age.

The causal direction in the association between respiratory syncytial virus hospitalization and asthma.

Prenatal determinants of neonatal lung function in high-risk newborns.

Exploring the association between severe respiratory syncytial virus infection and asthma: a registry-based twin study.

Safety and tolerability of montelukast in placebo-controlled pediatric studies and their open-label extensions.

Accuracy of whole-body plethysmography requires biological calibration.

Risk analysis of early childhood eczema.

17q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus late-onset asthma in North Americans of European ancestry.

Birth weight and risk of asthma in 3-9-year-old twins: exploring the fetal origins hypothesis.

Variants of DENND1B associated with asthma in children.

Upper and lower airway patency are associated in young children.

Increased risk of eczema but reduced risk of early wheezy disorder from exclusive breast-feeding in high-risk infants.

Elevated exhaled nitric oxide in high-risk neonates precedes transient early but not persistent wheeze.

A novel method for assessing unchallenged levels of mediators in nasal epithelial lining fluid.

Physical activity in young children is reduced with increasing bronchial responsiveness.

Causal direction between respiratory syncytial virus bronchiolitis and asthma studied in monozygotic twins.

Filaggrin gene variants and atopic diseases in early childhood assessed longitudinally from birth.

Long-term studies of the natural history of asthma in childhood.

Children with allergic and nonallergic rhinitis have a similar risk of asthma.

Transfer of maternal IgE can be a common cause of increased IgE levels in cord blood.

Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study.

Predictors of indoor fine particulate matter in infants' bedrooms in Denmark.

Endotyping early childhood asthma by quantitative symptom assessment.

Elevated eosinophil protein X in urine from healthy neonates precedes development of atopy in the first 6 years of life.

Robustness of genome-wide scanning using archived dried blood spot samples as a DNA source.

Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age.

Neonatal cytokine profile in the airway mucosal lining fluid is skewed by maternal atopy.

Coarse and fine particles but not ultrafine particles in urban air trigger hospital admission for asthma in children.

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.

"To wheeze or not to wheeze": that is not the question--the sequel.

Interaction between asthma and lung function growth in early life.

A genome-wide association meta-analysis identifies new childhood obesity loci.

Common variants at 12q15 and 12q24 are associated with infant head circumference.

Neonatal bronchial hyperresponsiveness precedes acute severe viral bronchiolitis in infants.

"To wheeze or not to wheeze": That is not the question.

Alcohol intake in pregnancy increases the child's risk of atopic dermatitis. the COPSAC prospective birth cohort study of a high risk population.

Skin barrier abnormality caused by filaggrin (FLG) mutations is associated with increased serum 25-hydroxyvitamin D concentrations.

Pharmacokinetic comparison of inhaled fixed combination vs. the free combination of beclomethasone and formoterol pMDIs in asthmatic children.

Polyunsaturated fatty acid content of mother's milk is associated with childhood body composition.

Living with cat and dog increases vaginal colonization with E. coli in pregnant women.

Validity of information on atopic disease and other illness in young children reported by parents in a prospective birth cohort study.

Infant acetaminophen use associates with early asthmatic symptoms independently of respiratory tract infections: the Copenhagen Prospective Study on Asthma in Childhood 2000 (COPSAC(2000)) cohort.

Use of antibiotics during pregnancy increases the risk of asthma in early childhood.

Clinical presentation of atopic dermatitis by filaggrin gene mutation status during the first 7 years of life in a prospective cohort study.

Fraction of exhaled nitric oxide and bronchial responsiveness are associated and continuous traits in young children independent of asthma.

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

Pathogenic bacteria colonizing the airways in asymptomatic neonates stimulates topical inflammatory mediator release.

Genome-wide Association and Longitudinal Analyses Reveal Genetic Loci Linking Pubertal Height Growth, Pubertal Timing, and Childhood Adiposity.

Rhinovirus wheezing illness and genetic risk of childhood-onset asthma.

Aerosol particle size does not predict pharmacokinetic determined lung dose in children.

Altered response to A(H1N1)pnd09 vaccination in pregnant women: a single blinded randomized controlled trial.

Objective assessment of levels and patterns of physical activity in preschool children.

Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.

Public hygiene campaign in denmark during the 2009 H1N1 pandemic had no effect on hospitalization rate of communicable diseases in children.

[Childhood asthma: Danish guidelines for diagnosis and treatment].

The PCDH1 gene and asthma in early childhood.

Increased risk of pneumonia and bronchiolitis after bacterial colonization of the airways as neonates.

Neonatal airway colonization is associated with troublesome lung symptoms in infants.

A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.

Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.

Prevalence and predictors of antibiotic administration during pregnancy and birth.

DENND1B gene variants associate with elevated exhaled nitric oxide in healthy high-risk neonates.

Effect of delivery device on systemic exposure to inhaled fluticasone propionate in children with asthma.

Preterm birth, infant weight gain, and childhood asthma risk: a meta-analysis of 147,000 European children.

Children with asthma by school age display aberrant immune responses to pathogenic airway bacteria as infants.

The systemic exposure to inhaled beclometasone/formoterol pMDI with valved holding chamber is independent of age and body size.

A clinical pharmacology study of fixed vs. free combination of inhaled beclometasone dipropionate and formoterol fumarate dry powder inhalers in asthmatic adolescents.

Prenatal and postnatal genetic influence on lung function development.

Cord blood 25(OH)-vitamin D deficiency and childhood asthma, allergy and eczema: the COPSAC2000 birth cohort study.

Maternal propensity for infections and risk of childhood asthma: a registry-based cohort study.

Airway mucosal immune-suppression in neonates of mothers receiving A(H1N1)pnd09 vaccination during pregnancy.

A novel common variant in DCST2 is associated with length in early life and height in adulthood.

Maternal antibiotic use and risk of asthma in offspring--Authors' reply.

Metagenomic heterogeneity explains dual immune effects of endotoxins.

Postmenopausal hormone therapy and asthma-related hospital admission.

Neonates with reduced neonatal lung function have systemic low-grade inflammation.

Breast-feeding does not protect against allergic sensitization in early childhood and allergy-associated disease at age 7 years.

Association between respiratory infections in early life and later asthma is independent of virus type.

Prelabor cesarean section bypasses natural immune cell maturation.

Duration of wheezy episodes in early childhood is independent of the microbial trigger.

Directional dominance on stature and cognition in diverse human populations.

Blood lipid levels associate with childhood asthma, airway obstruction, bronchial hyperresponsiveness, and aeroallergen sensitization.

Stable admission rate for acute asthma in Danish children since 1977.

Maternal fatty acid desaturase genotype correlates with infant immune responses at 6 months.

Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort.

The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts.

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.

[Reply: Allergy is not always the cause of asthma].

Early growth characteristics and the risk of reduced lung function and asthma: A meta-analysis of 25,000 children.

Season of birth shapes neonatal immune function.

Atopic endotype in childhood.

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.

Picornavirus-Induced Airway Mucosa Immune Profile in Asymptomatic Neonates.

Azithromycin for episodes with asthma-like symptoms in young children aged 1-3 years: a randomised, double-blind, placebo-controlled trial.

Effect of Vitamin D3 Supplementation During Pregnancy on Risk of Persistent Wheeze in the Offspring: A Randomized Clinical Trial.

Risk of Asthma from Cesarean Delivery Depends on Membrane Rupture.

Susceptibility to Lower Respiratory Infections in Childhood is Associated with Perturbation of the Cytokine Response to Pathogenic Airway Bacteria.

Chronic Chlamydia pneumoniae lung infection: a neglected explanation for macrolide effects in wheezing and asthma? - Authors' reply.

Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight.

New time-saving predictor algorithm for multiple breath washout in adolescents.

Cesarean section changes neonatal gut colonization.

Reply.

Genome-wide association study identifies 74 loci associated with educational attainment.

Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation.

A genome-wide association meta-analysis of diarrhoeal disease in young children identifies FUT2 locus and provides plausible biological pathways.

Preeclampsia Associates with Asthma, Allergy, and Eczema in Childhood.

In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections: A meta-analysis of birth cohort studies.

Genome-wide associations for birth weight and correlations with adult disease.

Genome-wide analysis identifies 12 loci influencing human reproductive behavior.

Incidence and Determinants of Ventilation Tubes in Denmark.

Large-scale benchmarking reveals false discoveries and count transformation sensitivity in 16S rRNA gene amplicon data analysis methods used in microbiome studies.

Knemometry is more sensitive to systemic effects of inhaled corticosteroids in children with asthma than 24-hour urine cortisol excretion.

Fish Oil-Derived Fatty Acids in Pregnancy and Wheeze and Asthma in Offspring.

The developing hypopharyngeal microbiota in early life.

No evidence of intrauterine sensitization against inhalant allergens.

Antibiotics in Pregnancy Increase Children's Risk of Otitis Media and Ventilation Tubes.

Shared genetic variants suggest common pathways in allergy and autoimmune diseases.

A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma.

Fish Oil in Pregnancy and Asthma in Offspring.

Sensitization trajectories in childhood revealed by using a cluster analysis.

Precision allergy: Separate allergies to male and female dogs.

Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium.

Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium.

Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus.