reproducible-motor-deficit-following-aortic-occlusion-rat-model

Reproducible Motor Deficit Following Aortic Occlusion in a Rat Model Of Spinal Cord Ischemia

Spinal cord ischemia is a fatal complication following thoracoabdominal aortic aneurysm surgery. Researchers can investigate the strategies for preventing ...

SNU Bundang Hospital, Seongnamsi, Gyeonggido, Republic of Korea

The McIvor blade, a tongue retractor with a thin curved blade, is used to improve the operating field during a tonsillectomy. We compared the success rate and incidence of complications between digital insertion and McIvor blade-guided insertion of the laryngeal mask airway (LMA™) ProSeal™ when performed by anesthesia residents in children.

The McIvor blade improves insertion of the LMA ProSeal™ in children.

We tested various doses of MgSO(4) to investigate the effect of Mg on a spinal cord ischemia.

Magnesium sulfate does not protect spinal cord against ischemic injury.

We measured the angular change from the line of vision to the larynx around the upper incisors under defined laryngoscopic forces and investigated its association with the laryngoscopic view.

Angular change in the line of vision to the larynx: implications for determining the laryngoscopic view.

Lung separation is essential for an emergency thoracic surgery for massive hemoptysis. When using a double lumen tube (DLT), a commonly adopted lung separation device during thoracic surgery, a water-tight seal of endobronchial cuff is crucial to prevent lung-to-lung aspiration of blood. In this study, we investigated the fluid sealing characteristics of the endobronchial cuff of a DLT and examined the effect of gel lubrication on the fluid leakage beyond the endobronchial cuff of DLT.

Prevention of lung-to-lung aspiration during emergency thoracic surgery: an experimental study.

Volatile anesthetics are a potential risk for cognitive impairment in the developing brain. Isoflurane causes cell death, reduces neurogenesis, and changes neuronal differentiation. In this study, the effects of a single isoflurane exposure on the developing human brain were evaluated using human embryonic stem cell (hESC)-derived neural progenitor cells (NPCs).

Isoflurane decreases proliferation and differentiation, but none of the effects persist in human embryonic stem cell-derived neural progenitor cells.

Ischemia and the following reperfusion damage are critical mechanisms of spinal cord injury. Statins have been reported to decrease ischemia-reperfusion injury in many organs including the spinal cord. Anti-oxidative effect is one of the main protective mechanisms of statin against neuronal death and cytotoxicity. We hypothesized that statins' anti-oxidative property would yield neuroprotective effects on spinal cord ischemia-reperfusion injury METHODS: Primary cultured spinal cord motor neurons were isolated from Sprague-Dawley rat fetuses. Ischemia-reperfusion injury model was induced by 60 min of oxygen and glucose deprivation (OGD) and 24 h of reoxygenation. Healthy and OGD cells were treated with simvastatin at concentrations of 0.1, 1, and 10 μM for 24 h. Cell viability was assessed using water-soluble tetrazolium salt (WST)-8, cytotoxicity with LDH, and production of free radicals with DCFDA (2',7'-dichlorofluorescein diacetate).

Simvastatin protects ischemic spinal cord injury from cell death and cytotoxicity through decreasing oxidative stress: in vitro primary cultured rat spinal cord model under oxygen and glucose deprivation-reoxygenation conditions.

The laryngoscope should displace oral soft tissues forward out of the operator's vision. Therefore, the space in front of the view may be critical for determining the laryngoscopic view. The aim was to investigate the difference in the previsional space during difficult versus easy laryngoscopy (EL).Under general anesthesia, digital photographs of the lateral view of the head and neck were taken in the horizontal sniffing position, after head extension, and during laryngoscopy with a defined force (50 N). Three points (thyroid notch (T), maxillary incisor (I), and mandibular mentum (M)) were marked on the photograph. The previsional space was defined as the TIM triangle. We compared these areas and other variables of the TIM triangle between male patients with difficult laryngoscopy (DL: Cormack-Lehane III-IV, n = 12) versus those of age- and body mass index-matched male patients with EL (Cormack-Lehane I-II, n = 12).When the head was extended, the areas TIM triangle in DL were significantly smaller than in EL. During laryngoscopy, all values of the TIM triangle in DL, including the TIM area (16.4 ± 3.7 vs 22.6 ± 2.8 cm, P < .01), were significantly smaller than the values in EL.The previsional space was smaller in patients with DL than in those with EL. The TIM triangle could suggest new way to explain the mechanism underlying DL.

Seongjoo Park

Department of Anesthesiology and Pain Medicine

SNU Bundang Hospital, Seongnamsi, Gyeonggido, Republic of Korea

Reproducible Motor Deficit Following Aortic Occlusion in a Rat Model Of Spinal Cord Ischemia

Seongjoo Park

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Department of Anesthesiology and Pain Medicine

SNU Bundang Hospital, Seongnamsi, Gyeonggido, Republic of Korea

Reproducible Motor Deficit Following Aortic Occlusion in a Rat Model Of Spinal Cord Ischemia

Department of Anesthesiology and Pain Medicine