Chi-Huey Wong

The Thioglycoside and Glycosyl Phosphite of 5-Azido Sialic Acid: Excellent Donors for the alpha-Glycosylation of Primary Hydroxy Groups This research was supported by Academia Sinica (Taipei) and the NIH (USA).

Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: functional and proteomic analyses of a fucose-containing glycoprotein fraction responsible for the activities.

Rapid diversity-oriented synthesis in microtiter plates for in situ screening: discovery of potent and selective alpha-fucosidase inhibitors.

Regioselective glycosylation of neamine core: a facile entry to kanamycin B related analogues.

Small molecules targeting severe acute respiratory syndrome human coronavirus.

Discovery of picomolar slow tight-binding inhibitors of alpha-fucosidase.

Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides.

Polysaccharides of Ganoderma lucidum alter cell immunophenotypic expression and enhance CD56+ NK-cell cytotoxicity in cord blood.

Plasma proteome of severe acute respiratory syndrome analyzed by two-dimensional gel electrophoresis and mass spectrometry.

Protein microarray using alpha-amino acids as metal tags on chips.

Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis.

The antioxidant protein alkylhydroperoxide reductase of Helicobacter pylori switches from a peroxide reductase to a molecular chaperone function.

Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease.

Multi-enzyme one-pot strategy for the synthesis of sialyl Lewis X-containing PSGL-1 glycopeptide.

Reishi polysaccharides induce immunoglobulin production through the TLR4/TLR2-mediated induction of transcription factor Blimp-1.

Screening for HIV protease inhibitors by protection against activity-mediated cytotoxicity in Escherichia coli.

Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo.

Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells.

Tailored glycoproteomics and glycan site mapping using saccharide-selective bioorthogonal probes.

Sugar-assisted ligation in glycoprotein synthesis.

Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids.

Structure-based design and synthesis of highly potent SARS-CoV 3CL protease inhibitors.

Synthesis of tamiflu and its phosphonate congeners possessing potent anti-influenza activity.

Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction.

Glycolipids as immunostimulating agents.

Domain requirement of moenomycin binding to bifunctional transglycosylases and development of high-throughput discovery of antibiotics.

Targeting the carbohydrates on HIV-1: Interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN.

Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease.

In vitro evaluation of neuraminidase inhibitors using the neuraminidase-dependent release assay of hemagglutinin-pseudotyped viruses.

Structure and bioactivity of the polysaccharides in medicinal plant Dendrobium huoshanense.

A concise and flexible synthesis of the potent anti-influenza agents tamiflu and tamiphosphor.

Glycan arrays on aluminum-coated glass slides.

Expression of Globo H and SSEA3 in breast cancer stem cells and the involvement of fucosyl transferases 1 and 2 in Globo H synthesis.

Glycan microarray of Globo H and related structures for quantitative analysis of breast cancer.

Sugar-assisted glycopeptide ligation with complex oligosaccharides: scope and limitations.

Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response.

Quantitative microarray analysis of intact glycolipid-CD1d interaction and correlation with cell-based cytokine production.

A consensus-hemagglutinin-based DNA vaccine that protects mice against divergent H5N1 influenza viruses.

The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability.

HA-pseudotyped retroviral vectors for influenza antagonist screening.

Crystal structure of the membrane-bound bifunctional transglycosylase PBP1b from Escherichia coli.

New development of glycan arrays.

Iron oxide/gold core/shell nanoparticles for ultrasensitive detection of carbohydrate-protein interactions.

Ganoderma lucidum Polysaccharides Induce Macrophage-Like Differentiation in Human Leukemia THP-1 Cells via Caspase and p53 Activation.

Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450BM3 demethylases.

Glycans on influenza hemagglutinin affect receptor binding and immune response.

The lifespan-promoting effect of acetic acid and Reishi polysaccharide.

Profiling carbohydrate-receptor interaction with recombinant innate immunity receptor-Fc fusion proteins.

6,8-Di-C-glycosyl flavonoids from Dendrobium huoshanense.

Highly alpha-selective sialyl phosphate donors for efficient preparation of natural sialosides.

Development of trifunctional probes for glycoproteomic analysis.

Combinatorial approach toward synthesis of small molecule libraries as bacterial transglycosylase inhibitors.

In vivo protection provided by a synthetic new alpha-galactosyl ceramide analog against bacterial and viral infections in murine models.

Regioselective synthesis of di-C-glycosylflavones possessing anti-inflammation activities.

Glycan array on aluminum oxide-coated glass slides through phosphonate chemistry.

Differential receptor binding affinities of influenza hemagglutinins on glycan arrays.

High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity.

Effect of Reishi polysaccharides on human stem/progenitor cells.

High-throughput identification of antibacterials against methicillin-resistant Staphylococcus aureus (MRSA) and the transglycosylase.

Combinatorial alanine substitution enables rapid optimization of cytochrome P450BM3 for selective hydroxylation of large substrates.

Modulation of substrate specificities of D-sialic acid aldolase through single mutations of Val-251.

Programmable one-pot glycosylation.

Effects of neighboring glycans on antibody-carbohydrate interaction.

Broadly neutralizing DNA vaccine with specific mutation alters the antigenicity and sugar-binding activities of influenza hemagglutinin.

Chemistry and glycobiology.

Vaccine design of hemagglutinin glycoprotein against influenza.

Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells.

Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets.

Total synthesis of polyprenyl N-glycolyl lipid II as a mycobacterial transglycosylase substrate.

E339...R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors.

A practical synthesis of zanamivir phosphonate congeners with potent anti-influenza activity.

Efficient and stereoselective synthesis of α(2→9) oligosialic acids: from monomers to dodecamers.

Avidity of CD1d-ligand-receptor ternary complex contributes to T-helper 1 (Th1) polarization and anticancer efficacy.

Toward automated oligosaccharide synthesis.

Engineering transaldolase in Pichia stipitis to improve bioethanol production.

Infection of differentiated porcine airway epithelial cells by influenza virus: differential susceptibility to infection by porcine and avian viruses.

Acyl and silyl group effects in reactivity-based one-pot glycosylation: synthesis of embryonic stem cell surface carbohydrates Lc4 and IV(2)Fuc-Lc4.

Crystal structure of Staphylococcus aureus transglycosylase in complex with a lipid II analog and elucidation of peptidoglycan synthesis mechanism.

α-Glycosylation by D-glucosamine-derived donors: synthesis of heparosan and heparin analogues that interact with mycobacterial heparin-binding hemagglutinin.

Effect of the peptide moiety of Lipid II on bacterial transglycosylase.

Development of oseltamivir phosphonate congeners as anti-influenza agents.

6-alkynyl fucose is a bioorthogonal analog for O-fucosylation of epidermal growth factor-like repeats and thrombospondin type-1 repeats by protein O-fucosyltransferases 1 and 2.

Chemical probes for drug-resistance assessment by binding competition (RABC): oseltamivir susceptibility evaluation.

Rapid preparation of mycobacterium N-glycolyl Lipid I and Lipid II derivatives: a biocatalytic approach.

Fucosyltransferase 8 as a functional regulator of nonsmall cell lung cancer.

Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer.

Cell-permeable probe for identification and imaging of sialidases.

The immunologically active oligosaccharides isolated from wheatgrass modulate monocytes via Toll-like receptor-2 signaling.

Synthesis and bioactivity of β-(1→4)-linked oligomannoses and partially acetylated derivatives.

CLEC4F is an inducible C-type lectin in F4/80-positive cells and is involved in alpha-galactosylceramide presentation in liver.

B-cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention.

Different immunity elicited by recombinant H5N1 hemagglutinin proteins containing pauci-mannose, high-mannose, or complex type N-glycans.

Synthesis and vaccine evaluation of the tumor-associated carbohydrate antigen RM2 from prostate cancer.

Synthesis of Neisseria meningitidis serogroup W135 capsular oligosaccharides for immunogenicity comparison and vaccine development.

Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes.

Efficient convergent synthesis of bi-, tri-, and tetra-antennary complex type N-glycans and their HIV-1 antigenicity.

Effective sugar nucleotide regeneration for the large-scale enzymatic synthesis of Globo H and SSEA4.

New continuous fluorometric assay for bacterial transglycosylase using Förster resonance energy transfer.

Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase.

The surface carbohydrates of the Echinococcus granulosus larva interact selectively with the rodent Kupffer cell receptor.

Vaccination of monoglycosylated hemagglutinin induces cross-strain protection against influenza virus infections.

O-GlcNAcylation regulates EZH2 protein stability and function.

Chemical constituents of Plectranthus amboinicus and the synthetic analogs possessing anti-inflammatory activity.

Stage-specific embryonic antigen-4 as a potential therapeutic target in glioblastoma multiforme and other cancers.

Characterization of the sialic acid binding activity of influenza A viruses using soluble variants of the H7 and H9 hemagglutinins.

The multifaceted effects of polysaccharides isolated from Dendrobium huoshanense on immune functions with the induction of interleukin-1 receptor antagonist (IL-1ra) in monocytes.

Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers.

Development of bacterial transglycosylase inhibitors as new antibiotics: moenomycin A treatment for drug-resistant Helicobacter pylori.

Potent adjuvant effects of novel NKT stimulatory glycolipids on hemagglutinin based DNA vaccine for H5N1 influenza virus.

Tamiphosphor monoesters as effective anti-influenza agents.

An azido-BODIPY probe for glycosylation: initiation of strong fluorescence upon triazole formation.

Enzymatic synthesis of lipid II and analogues.

Sequence-constructive SELEX: a new strategy for screening DNA aptamer binding to Globo H.

Immunogenicity study of Globo H analogues with modification at the reducing or nonreducing end of the tumor antigen.

Oseltamivir hydroxamate and acyl sulfonamide derivatives as influenza neuraminidase inhibitors.

Development of Globo-H cancer vaccine.

Glycopeptide mimetics recapitulate high-mannose-type oligosaccharide binding and function.

Effect of sialylation on EGFR phosphorylation and resistance to tyrosine kinase inhibition.

Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity.

Chemistry in Taiwan and Academia Sinica.

A common glycan structure on immunoglobulin G for enhancement of effector functions.

Colocalization of a CD1d-Binding Glycolipid with a Radiation-Attenuated Sporozoite Vaccine in Lymph Node-Resident Dendritic Cells for a Robust Adjuvant Effect.

Glycoprotein B7-H3 overexpression and aberrant glycosylation in oral cancer and immune response.

Latifolicinin A from a Fermented Soymilk Product and the Structure-Activity Relationship of Synthetic Analogues as Inhibitors of Breast Cancer Cell Growth.

Identification of Common Features in Prototype Broadly Neutralizing Antibodies to HIV Envelope V2 Apex to Facilitate Vaccine Design.

Stage-specific embryonic antigen-3 (SSEA-3) and β3GalT5 are cancer specific and significant markers for breast cancer stem cells.

Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies.

Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G.

Glycolipid GD3 and GD3 synthase are key drivers for glioblastoma stem cells and tumorigenicity.

Understanding the Chemistry and Biology of Glycosylation with Glycan Synthesis.

Peramivir Phosphonate Derivatives as Influenza Neuraminidase Inhibitors.

Exploring human glycosylation for better therapies.

Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose Patch.

The Dependence of Carbohydrate-Aromatic Interaction Strengths on the Structure of the Carbohydrate.

A Prominent Site of Antibody Vulnerability on HIV Envelope Incorporates a Motif Associated with CCR5 Binding and Its Camouflaging Glycans.

High-Sensitivity and Low-Toxicity Fucose Probe for Glycan Imaging and Biomarker Discovery.

Purine-Type Compounds Induce Microtubule Fragmentation and Lung Cancer Cell Death through Interaction with Katanin.

Phenyl Glycolipids with Different Glycosyl Groups Exhibit Marked Differences in Murine and Human iNKT Cell Activation.

Dengue Virus Infection Is through a Cooperative Interaction between a Mannose Receptor and CLEC5A on Macrophage as a Multivalent Hetero-Complex.

Influenza A surface glycosylation and vaccine design.

A cell-permeable and triazole-forming fluorescent probe for glycoconjugate imaging in live cells.

An Effective Bacterial Fucosidase for Glycoprotein Remodeling.

Crystal Structure of a Homogeneous IgG-Fc Glycoform with the N-Glycan Designed to Maximize the Antibody Dependent Cellular Cytotoxicity.

Autoreactivity to Sulfatide by Human Invariant NKT Cells.

Substrate Preference and Interplay of Fucosyltransferase 8 and N-Acetylglucosaminyltransferases.

Residues Comprising the Enhanced Aromatic Sequon Influence Protein N-Glycosylation Efficiency.

Undecaprenyl Phosphate Phosphatase Activity of Undecaprenol Kinase Regulates the Lipid Pool in Gram-Positive Bacteria.

Glycans Function as Anchors for Antibodies and Help Drive HIV Broadly Neutralizing Antibody Development.

An Alkynyl-Fucose Halts Hepatoma Cell Migration and Invasion by Inhibiting GDP-Fucose-Synthesizing Enzyme FX, TSTA3.

The 2-anilino-4-amino-5-aroylthiazole-type compound AS7128 inhibits lung cancer growth through decreased iASPP and p53 interaction.

Glycoengineering of antibody (Herceptin) through yeast expression and in vitro enzymatic glycosylation.

Free-electron-laser coherent diffraction images of individual drug-carrying liposome particles in solution.

Affinity-Based Screen for Inhibitors of Bacterial Transglycosylase.

A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope.

Unprecedented Role of Hybrid N-Glycans as Ligands for HIV-1 Broadly Neutralizing Antibodies.

Towards new antibiotics targeting bacterial transglycosylase: Synthesis of a Lipid II analog as stable transition-state mimic inhibitor.

The Thioglycoside and Glycosyl Phosphite of 5-Azido Sialic Acid: Excellent Donors for the α-Glycosylation of Primary Hydroxy Groups.

-GlcNAcylation regulates the stability and enzymatic activity of the histone methyltransferase EZH2.

Preparation of Aluminum Oxide-Coated Glass Slides for Glycan Microarrays.

Programmable one-pot synthesis of heparin pentasaccharides enabling access to regiodefined sulfate derivatives.

Development of a universal influenza vaccine using hemagglutinin stem protein produced from Pichia pastoris.

Hierarchical and programmable one-pot synthesis of oligosaccharides.

Oligosaccharide Synthesis and Translational Innovation.

Egg-based influenza split virus vaccine with monoglycosylation induces cross-strain protection against influenza virus infections.

Signaling pathway of globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5) in breast cancer.

Synthesis of Sialidase-Resistant Oligosaccharide and Antibody Glycoform Containing α2,6-Linked 3F-Neu5Ac.

Synthesis of Modular Building Blocks using Glycosyl Phosphate Donors for the Construction of Asymmetric N-Glycans.

An Efficient Modular One-Pot Synthesis of Heparin-Based Anticoagulant Idraparinux.

Targeting the Bacterial Transglycosylase: Antibiotic Development from a Structural Perspective.

Structure-guided development of purine amide, hydroxamate, and amidoxime for the inhibition of non-small cell lung cancer.

4(1H)-quinolone derivatives overcome acquired resistance to anti-microtubule agents by targeting the colchicine site of β-tubulin.