Kartik Balachandran

An ex vivo study of the biological properties of porcine aortic valves in response to circumferential cyclic stretch.

Design of an ex vivo culture system to investigate the effects of shear stress on cardiovascular tissue.

Altered shear stress stimulates upregulation of endothelial VCAM-1 and ICAM-1 in a BMP-4- and TGF-beta1-dependent pathway.

Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve disease.

Endothelium-dependent regulation of the mechanical properties of aortic valve cusps.

Dynamic deformation characteristics of porcine aortic valve leaflet under normal and hypertensive conditions.

Elevated cyclic stretch induces aortic valve calcification in a bone morphogenic protein-dependent manner.

Mechanics of the mitral valve strut chordae insertion region.

The effects of combined cyclic stretch and pressure on the aortic valve interstitial cell phenotype.

Regional analysis of dynamic deformation characteristics of native aortic valve leaflets.

Aortic valve cyclic stretch causes increased remodeling activity and enhanced serotonin receptor responsiveness.

Hemodynamics and mechanobiology of aortic valve inflammation and calcification.

Elevated cyclic stretch and serotonin result in altered aortic valve remodeling via a mechanosensitive 5-HT(2A) receptor-dependent pathway.

Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve.

Engineering hybrid polymer-protein super-aligned nanofibers via rotary jet spinning.

Characterization of thin poly(dimethylsiloxane)-based tissue-simulating phantoms with tunable reduced scattering and absorption coefficients at visible and near-infrared wavelengths.

The mechanobiology of drug-induced cardiac valve disease.

Valve interstitial cell shape modulates cell contractility independent of cell phenotype.

Acetazolamide Mitigates Astrocyte Cellular Edema Following Mild Traumatic Brain Injury.

Engineering anisotropic biphasic Janus-type polymer nanofiber scaffold networks via centrifugal jet spinning.

Valve interstitial cell contractile strength and metabolic state are dependent on its shape.

Elevated Serotonin Interacts with Angiotensin-II to Result in Altered Valve Interstitial Cell Contractility and Remodeling.

Fabrication of a matrigel-collagen semi-interpenetrating scaffold for use in dynamic valve interstitial cell culture.

Characterization of Biaxial Stretch as an In Vitro Model of Traumatic Brain Injury to the Blood-Brain Barrier.