Ulrik Gether

Use of fluorescence spectroscopy to study conformational changes in the beta 2-adrenoceptor.

Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle.

The role of zinc ions in reverse transport mediated by monoamine transporters.

Zn(2+) site engineering at the oligomeric interface of the dopamine transporter.

Passive water and urea permeability of a human Na(+)-glutamate cotransporter expressed in Xenopus oocytes.

Conformational basis for the Li(+)-induced leak current in the rat gamma-aminobutyric acid (GABA) transporter-1.

N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization.

Structural basis for activation of G-protein-coupled receptors.

Residues in the extracellular loop 4 are critical for maintaining the conformational equilibrium of the gamma-aminobutyric acid transporter-1.

Evidence for distinct sodium-, dopamine-, and cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine transporter.

Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding.

Structural and functional probing of the biogenic amine transporters by fluorescence spectroscopy.

Probing dopamine transporter structure and function by Zn2+-site engineering.

Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ domain interactions.

Zinc potentiates an uncoupled anion conductance associated with the dopamine transporter.

Purification and fluorescent labeling of the human serotonin transporter.

Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2.

Molecular determinants for the complex binding specificity of the PDZ domain in PICK1.

Identification of intra- and intermolecular disulfide bridges in the multidrug resistance transporter ABCG2.

Intramolecular cross-linking in a bacterial homolog of mammalian SLC6 neurotransmitter transporters suggests an evolutionary conserved role of transmembrane segments 7 and 8.

Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter.

Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype.

Regulation of dopamine transporter trafficking by intracellular amphetamine.

Phosphorylation of the norepinephrine transporter at threonine 258 and serine 259 is linked to protein kinase C-mediated transporter internalization.

Neurotransmitter transporters: molecular function of important drug targets.

Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport.

Allosteric effects of R- and S-citalopram on the human 5-HT transporter: evidence for distinct high- and low-affinity binding sites.

Membrane mobility and microdomain association of the dopamine transporter studied with fluorescence correlation spectroscopy and fluorescence recovery after photobleaching.

Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors.

Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1.

Glycine transporter dimers: evidence for occurrence in the plasma membrane.

An intracellular interaction network regulates conformational transitions in the dopamine transporter.

Recruitment of beta-arrestin2 to the dopamine D2 receptor: insights into anti-psychotic and anti-parkinsonian drug receptor signaling.

Membrane localization is critical for activation of the PICK1 BAR domain.

The binding sites for cocaine and dopamine in the dopamine transporter overlap.

Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux.

Correlation between genetic and geographic structure in Europe.

An evaluation of the genetic-matched pair study design using genome-wide SNP data from the European population.

Do stressful life events predict medical treatment outcome in first episode of depression?

Validity of the diagnosis of a single depressive episode in a case register.

Interaction between genetic polymorphisms and stressful life events in first episode depression.

Elucidating conformational changes in the gamma-aminobutyric acid transporter-1.

Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs.

A single nucleotide polymorphism in the human serotonin transporter introduces a new site for N-linked glycosylation.

Rationale and design of the participant, investigator, observer, and data-analyst-blinded randomized AGENDA trial on associations between gene-polymorphisms, endophenotypes for depression and antidepressive intervention: the effect of escitalopram versus placebo on the combined dexamethasone-corticotrophine releasing hormone test and other potential endophenotypes in healthy first-degree relatives of persons with depression.

Does bereavement-related first episode depression differ from other kinds of first depressions?

How curved membranes recruit amphipathic helices and protein anchoring motifs.

PICK1 expression in the Drosophila central nervous system primarily occurs in the neuroendocrine system.

Amphipathic motifs in BAR domains are essential for membrane curvature sensing.

Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.

No interactions between genetic polymorphisms and stressful life events on outcome of antidepressant treatment.

Regulation of dopamine transporter function by protein-protein interactions: new discoveries and methodological challenges.

The N terminus of monoamine transporters is a lever required for the action of amphetamines.

Gender differences among patients with a single depressive episode.

The influence of comorbid personality disorder and neuroticism on treatment outcome in first episode depression.

David versus Goliath.

Postendocytic sorting of constitutively internalized dopamine transporter in cell lines and dopaminergic neurons.

Clinical utility of Standardised Assessment of Personality - Abbreviated Scale (SAPAS) among patients with first episode depression.

Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1.

The binding sites for benztropines and dopamine in the dopamine transporter overlap.

Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins.

Tandem facial amphiphiles for membrane protein stabilization.

Copy number variations in affective disorders and meta-analysis.

A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain.

Escitalopram and neuroendocrine response in healthy first-degree relatives to depressed patients--a randomized placebo-controlled trial.

SLC6 neurotransmitter transporters: structure, function, and regulation.

Differences between early and late onset adult depression.

Brain-derived neurotrophic factor (BDNF) enhances GABA transport by modulating the trafficking of GABA transporter-1 (GAT-1) from the plasma membrane of rat cortical astrocytes.

Serine 77 in the PDZ domain of PICK1 is a protein kinase Cα phosphorylation site regulated by lipid membrane binding.

Protein interacting with C kinase 1 (PICK1) reduces reinsertion rates of interaction partners sorted to Rab11-dependent slow recycling pathway.

Effect of chronic escitalopram versus placebo on personality traits in healthy first-degree relatives of patients with depression: a randomized trial.

The solute carrier 6 family of transporters.

The effect of escitalopram versus placebo on perceived stress and salivary cortisol in healthy first-degree relatives of patients with depression-A randomised trial.

A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins.

A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter, LeuT.

Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter.

Glucose-Neopentyl Glycol (GNG) amphiphiles for membrane protein study.

A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter.

PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance.

Genome-Wide Association Study of Genetic Variants in LPS-Stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α Cytokine Response in a Danish Cohort.

Membrane-permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release.

AMPA receptor pHluorin-GluA2 reports NMDA receptor-induced intracellular acidification in hippocampal neurons.

A randomized trial of the effect of escitalopram versus placebo on cognitive function in healthy first-degree relatives of patients with depression.

Novel tripod amphiphiles for membrane protein analysis.

Serotonin-induced down-regulation of cell surface serotonin transporter.

Reply to Wilkinson et al.: Concerning the use of pHluorin-tagged GluA2 as a reporter for NMDA-induced AMPA receptor recycling.

In vivo amphetamine action is contingent on αCaMKII.

Missense dopamine transporter mutations associate with adult parkinsonism and ADHD.

Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram.

The serotonin transporter undergoes constitutive internalization and is primarily sorted to late endosomes and lysosomal degradation.

Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/discs-large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands.

The second sodium site in the dopamine transporter controls cation permeation and is regulated by chloride.

The BAR domain protein PICK1 controls vesicle number and size in adrenal chromaffin cells.

Akt-mediated regulation of antidepressant-sensitive serotonin transporter function, cell-surface expression and phosphorylation.

Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (hDAT R51W) in dopamine neurotransmission and behaviors.

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters.

Amphetamine action at the cocaine- and antidepressant-sensitive serotonin transporter is modulated by αCaMKII.

Structure of Dimeric and Tetrameric Complexes of the BAR Domain Protein PICK1 Determined by Small-Angle X-Ray Scattering.

A novel dopamine transporter transgenic mouse line for identification and purification of midbrain dopaminergic neurons reveals midbrain heterogeneity.

[Optogenetics brings hidden neural mechanisms into the light and could become a future therapy].

Substrate-induced unlocking of the inner gate determines the catalytic efficiency of a neurotransmitter:sodium symporter.

No effect of escitalopram versus placebo on brain-derived neurotrophic factor in healthy individuals: a randomised trial.

Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the 5-HT transporter.

Effect of escitalopram versus placebo on GRα messenger RNA expression in peripheral blood cells of healthy individuals with a family history of depression - a secondary outcome analysis from the randomized AGENDA trial.

Differential Internalization Rates and Postendocytic Sorting of the Norepinephrine and Dopamine Transporters Are Controlled by Structural Elements in the N Termini.

Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression.

A kinome wide screen identifies novel kinases involved in regulation of monoamine transporter function.

Structural biology: Antidepressants at work.

Preserved dopaminergic homeostasis and dopamine-related behaviour in hemizygous TH-Cre mice.

Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290.

Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter.

The Environment Shapes the Inner Vestibule of LeuT.

Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR.

The GPRC6A receptor displays constitutive internalization and sorting to the slow recycling pathway.

Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer.

Chemogenetic Modulation of G Protein-Coupled Receptor Signalling in Visual Attention Research.

Subjective perception of cocaine reward in mice assessed by a single exposure place preference (sePP) paradigm.