Kristine E. Yoder
Department of Cancer Biology and Genetics
The Ohio State University College of Medicine
I earned my BS in Biology from the Massachusetts Institute of Technology in 1993. During that time I spent a summer in the red tide phytoplankton lab of Dr. Donald Anderson, PhD, at the Woods Hole Oceanographic Institute located on Cape Cod. Following graduation from MIT, I spent two years as a technician in the lab of Dr. David Relman, MD, at Stanford University identifying unrecognizable pathogens. I then entered graduate school at the University of California, San Diego, and joined the lab of Dr. Rick Bushman, PhD, at the Salk Institute studying HIV integration. My postdoctoral studies continued to explore the relationship of host DNA repair proteins and retroviral cDNA metabolism at Thomas Jefferson University in Philadelphia with Dr. Carlo Croce, MD, and Dr. Richard Fishel, PhD. These groups later moved to The Ohio State University College of Medicine where I was promoted to Assistant Professor in the department of Cancer Biology and Genetics (formerly Molecular Virology, Immunology, and Medical Genetics). My lab is investigating the mechanism of retroviral integration at the single molecule level and using CRISPR genome editing to investigate retroviral biology.
PCR-based detection is unable to consistently distinguish HIV 1LTR circles.
Journal of virological methods Dec, 2006 | Pubmed ID: 16956673
Real-time quantitative PCR and fast QPCR have similar sensitivity and accuracy with HIV cDNA late reverse transcripts and 2-LTR circles.
Journal of virological methods Nov, 2008 | Pubmed ID: 18762215
XPB mediated retroviral cDNA degradation coincides with entry to the nucleus.
Virology Feb, 2011 | Pubmed ID: 21167544
The base excision repair pathway is required for efficient lentivirus integration.
PloS one , 2011 | Pubmed ID: 21448280
Repair of oxidative DNA base damage in the host genome influences the HIV integration site sequence preference.
PloS one , 2014 | Pubmed ID: 25051054
Widespread nuclease contamination in commonly used oxygen-scavenging systems.
Nature methods Oct, 2015 | Pubmed ID: 26418762
Retroviral intasomes search for a target DNA by 1D diffusion which rarely results in integration.
Nature communications 04, 2016 | Pubmed ID: 27108531
Removal of nuclease contamination during purification of recombinant prototype foamy virus integrase.
Journal of virological methods Sep, 2016 | Pubmed ID: 27269588
Host Double Strand Break Repair Generates HIV-1 Strains Resistant to CRISPR/Cas9.
Scientific reports 07, 2016 | Pubmed ID: 27404981
Expression and purification of nuclease-free protocatechuate 3,4-dioxygenase for prolonged single-molecule fluorescence imaging.
Analytical biochemistry 09, 2018 | Pubmed ID: 29932890
Prototype foamy virus integrase is promiscuous for target choice.
Biochemical and biophysical research communications 09, 2018 | Pubmed ID: 30017200
CRISPR/Cas9 Genome Editing to Disable the Latent HIV-1 Provirus.
Frontiers in microbiology , 2018 | Pubmed ID: 30619186
Prototype foamy virus intasome aggregation is mediated by outer protein domains and prevented by protocatechuic acid.
Scientific reports Jan, 2019 | Pubmed ID: 30644416
Nucleosome DNA unwrapping does not affect prototype foamy virus integration efficiency or site selection.
PloS one , 2019 | Pubmed ID: 30865665
Detection and Removal of Nuclease Contamination During Purification of Recombinant Prototype Foamy Virus Integrase
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