Demin Zhou

A method for detecting and preventing negative RNA interference in preparation of lentiviral vectors for siRNA delivery.

Strand antagonism in RNAi: an explanation of differences in potency between intracellularly expressed siRNA and shRNA.

c-Met inhibitor SU11274 enhances the response of the prostate cancer cell line DU145 to ionizing radiation.

Honokiol inhibits the inflammatory reaction during cerebral ischemia reperfusion by suppressing NF-κB activation and cytokine production of glial cells.

Development of oleanane-type triterpenes as a new class of HCV entry inhibitors.

Nitrosporeusines A and B, unprecedented thioester-bearing alkaloids from the Arctic Streptomyces nitrosporeus.

Synthesis and anti-HCV entry activity studies of β-cyclodextrin-pentacyclic triterpene conjugates.

Development of bivalent oleanane-type triterpenes as potent HCV entry inhibitors.

Uralsaponins M-Y, antiviral triterpenoid saponins from the roots of Glycyrrhiza uralensis.

Response and adaptation of Escherichia coli to suppression of the amber stop codon.

A single molecular probe for multi-analyte (Cr³⁺, Al³⁺ and Fe³⁺) detection in aqueous medium and its biological application.

TPGS-g-PLGA/Pluronic F68 mixed micelles for tanshinone IIA delivery in cancer therapy.

Discovery of pentacyclic triterpenoids as potential entry inhibitors of influenza viruses.

A selective NIR-emitting zinc sensor by using Schiff base binding to turn-on excited-state intramolecular proton transfer.

Elevated expression of AKR1C3 increases resistance of cancer cells to ionizing radiation via modulation of oxidative stress.

c-Met targeting enhances the effect of irradiation and chemical agents against malignant colon cells harboring a KRAS mutation.

The use of α-conotoxin ImI to actualize the targeted delivery of paclitaxel micelles to α7 nAChR-overexpressing breast cancer.

Neoechinulin B and its analogues as potential entry inhibitors of influenza viruses, targeting viral hemagglutinin.

Broadening the versatility of lentiviral vectors as a tool in nucleic acid research via genetic code expansion.

Development of next generation of therapeutic IFN-α2b via genetic code expansion.

Transition Metal-Free Oxidative Radical Decarboxylation/Cyclization for the Construction of 6-Alkyl/Aryl Phenanthridines.

Synthesis and biological evaluation of ring A and/or C expansion and opening echinocystic acid derivatives for anti-HCV entry inhibitors.

Potential involvement of miR-375 in the premalignant progression of oral squamous cell carcinoma mediated via transcription factor KLF5.

Pentacyclic triterpenes grafted on CD cores to interfere with influenza virus entry: A dramatic multivalent effect.

Spiromastilactones: A new class of influenza virus inhibitors from deep-sea fungus.

Development of next generation adeno-associated viral vectors capable of selective tropism and efficient gene delivery.

CRISPRi-Manipulation of Genetic Code Expansion via RF1 for Reassignment of Amber Codon in Bacteria.

Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine.

Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors.

Inter-molecular β-sheet structure facilitates lung-targeting siRNA delivery.

Data on interaction between adeno-associated virus and U87 cell via cRGD chemical modification.

Re-exploration of the Codon Context Effect on Amber Codon-Guided Incorporation of Noncanonical Amino Acids in Escherichia coli by the Blue-White Screening Assay.

Overexpression of AKR1C3 significantly enhances human prostate cancer cells resistance to radiation.

Synthesis and biological evaluation of novel pentacyclic triterpene α-cyclodextrin conjugates as HCV entry inhibitors.

Synthesis of Site-Specific Radiolabeled Antibodies for Radioimmunotherapy via Genetic Code Expansion.

AC220 and AraC cause differential inhibitory dynamics in patient-derived M5-AML with FLT3-ITD and, thus, ultimately distinct therapeutic outcomes.

Generation of influenza A viruses as live but replication-incompetent virus vaccines.

Precise and combinatorial PEGylation generates a low-immunogenic and stable form of human growth hormone.

Design, synthesis and biological evaluation of gentiopicroside derivatives as potential antiviral inhibitors.

Inhibition of influenza virus infection by multivalent pentacyclic triterpene-functionalized per-O-methylated cyclodextrin conjugates.

Fatty acid synthase cooperates with protrudin to facilitate membrane outgrowth of cellular protrusions.

Eg5 inhibitor YL001 induces mitotic arrest and inhibits tumor proliferation.

Construction of an inducible stable cell line for efficient incorporation of unnatural amino acids in mammalian cells.

Site-Specific PEGylated Adeno-Associated Viruses with Increased Serum Stability and Reduced Immunogenicity.

Redirecting Killer T Cells through Incorporation of Azido Sugars for Tethering Ligands.

A Nanosystem of Amphiphilic Oligopeptide-Drug Conjugate Actualizing Both αvβ3 Targeting and Reduction-Triggered Release for Maytansinoid.

Recent progress in the antiviral activity and mechanism study of pentacyclic triterpenoids and their derivatives.

Precision Fluorescent Labeling of an Adeno-Associated Virus Vector to Monitor the Viral Infection Pathway.

Design, synthesis and biological evaluation of water-soluble per-O-methylated cyclodextrin-C conjugates as anti-influenza virus agents.

Truncateols O-V, further isoprenylated cyclohexanols from the sponge-associated fungus Truncatella angustata with antiviral activities.

Synthesis of novel pentacyclic triterpene-Neu5Ac2en derivatives and investigation of their anti-influenza entry activity.