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Department of Molecular Biology
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MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2017 | Pubmed ID: 28827318
Thioredoxin-1 actively maintains the pseudokinase MLKL in a reduced state to suppress disulfide bond-dependent MLKL polymer formation and necroptosis.
The Journal of biological chemistry 10, 2017 | Pubmed ID: 28878015
UT Southwestern Medical Center
Sarah Hanna-Addams1,
Zhigao Wang1
1Department of Molecular Biology, UT Southwestern Medical Center
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