George M. Church

Exploring the DNA-binding specificities of zinc fingers with DNA microarrays.

Nucleotides of transcription factor binding sites exert interdependent effects on the binding affinities of transcription factors.

A motif co-occurrence approach for genome-wide prediction of transcription-factor-binding sites in Escherichia coli.

The complete genome and proteome of Mycoplasma mobile.

Genomic analysis of LexA binding reveals the permissive nature of the Escherichia coli genome and identifies unconventional target sites.

The transition between transcriptional initiation and elongation in E. coli is highly variable and often rate limiting.

The most conserved genome segments for life detection on Earth and other planets.

Rapid prototyping of 3D DNA-origami shapes with caDNAno.

Programming cells by multiplex genome engineering and accelerated evolution.

Free Factories: Unified Infrastructure for Data Intensive Web Services.

Reprogramming of T cells from human peripheral blood.

Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription.

A new dawn for industrial photosynthesis.

Autoantigen discovery with a synthetic human peptidome.

Precise manipulation of chromosomes in vivo enables genome-wide codon replacement.

High-throughput multiplex sequencing of miRNA.

Genome-scale promoter engineering by coselection MAGE.

Enhanced multiplex genome engineering through co-operative oligonucleotide co-selection.

A BioBrick compatible strategy for genetic modification of plants.

Multiplexed in vivo His-tagging of enzyme pathways for in vitro single-pot multienzyme catalysis.

How accurate can genetic predictions be?

Improving lambda red genome engineering in Escherichia coli via rational removal of endogenous nucleases.

Submicrometre geometrically encoded fluorescent barcodes self-assembled from DNA.

RNA-guided human genome engineering via Cas9.

PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis.

Barcoding cells using cell-surface programmable DNA-binding domains.

Nanotools for neuroscience and brain activity mapping.

Research, collaboration, and open science using web 2.0.

Heritable genome editing in C. elegans via a CRISPR-Cas9 system.

Optical control of mammalian endogenous transcription and epigenetic states.

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering.

Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9.

Heritable custom genomic modifications in Caenorhabditis elegans via a CRISPR-Cas9 system.

Natural reassignment of CUU and CUA sense codons to alanine in Ashbya mitochondria.

Cas9 as a versatile tool for engineering biology.

Genomically recoded organisms expand biological functions.

Physical principles for scalable neural recording.

The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies.

The role of replicates for error mitigation in next-generation sequencing.

Rational optimization of tolC as a powerful dual selectable marker for genome engineering.

Highly multiplexed subcellular RNA sequencing in situ.

Realizing the potential of synthetic biology.

High-resolution antibody dynamics of vaccine-induced immune responses.

Syntrophic exchange in synthetic microbial communities.

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies.

Direct mutagenesis of thousands of genomic targets using microarray-derived oligonucleotides.

CHOPCHOP: a CRISPR/Cas9 and TALEN web tool for genome editing.

Genome editing assessment using CRISPR Genome Analyzer (CRISPR-GA).

Multiplex single-molecule interaction profiling of DNA-barcoded proteins.

Engineering allostery.

Rapid neurogenesis through transcriptional activation in human stem cells.

Multi-kilobase homozygous targeted gene replacement in human induced pluripotent stem cells.

Evolution-guided optimization of biosynthetic pathways.

Biocontainment of genetically modified organisms by synthetic protein design.

Spatial information in large-scale neural recordings.

Highly efficient Cas9-mediated transcriptional programming.

Synthetic biosensors for precise gene control and real-time monitoring of metabolites.

Unraveling CRISPR-Cas9 genome engineering parameters via a library-on-library approach.

Bioart.

Engineering an allosteric transcription factor to respond to new ligands.

Tools for the Microbiome: Nano and Beyond.

A general strategy to construct small molecule biosensors in eukaryotes.

In vivo gene editing in dystrophic mouse muscle and muscle stem cells.

Genetically encoded sensors enable real-time observation of metabolite production.

Multiplexed Engineering in Biology.

Biosensor-based engineering of biosynthetic pathways.

Nucleic acid memory.

Real-time single-molecule electronic DNA sequencing by synthesis using polymer-tagged nucleotides on a nanopore array.

Precision Chemistry for Precision Medicine.

Molecular recordings by directed CRISPR spacer acquisition.

Design, synthesis, and testing toward a 57-codon genome.

CRISPR-Cas9 System: Opportunities and Concerns.

A multifunctional AAV-CRISPR-Cas9 and its host response.

Emergent rules for codon choice elucidated by editing rare arginine codons in Escherichia coli.

Design and characterization of a nanopore-coupled polymerase for single-molecule DNA sequencing by synthesis on an electrode array.

Complete mitochondrial genomes of living and extinct pigeons revise the timing of the columbiform radiation.

Rapidly evolving homing CRISPR barcodes.

Efficient, footprint-free human iPSC genome editing by consolidation of Cas9/CRISPR and piggyBac technologies.

Cushing's syndrome mutant PKA exhibits altered substrate specificity.

sgRNA Scorer 2.0: A Species-Independent Model To Predict CRISPR/Cas9 Activity.

Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform.

An unbiased index to quantify participant's phenotypic contribution to an open-access cohort.

Evolutionary dynamics of CRISPR gene drives.

Nucleotide-time alignment for molecular recorders.

Optimizing complex phenotypes through model-guided multiplex genome engineering.

Millstone: software for multiplex microbial genome analysis and engineering.

Scalable Device for Automated Microbial Electroporation in a Digital Microfluidic Platform.

CRISPR-Cas encoding of a digital movie into the genomes of a population of living bacteria.

Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder.

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9.

Extracellular Vesicle Isolation and Analysis by Western Blotting.

Imaging of Isolated Extracellular Vesicles Using Fluorescence Microscopy.

Rapid Sequential in Situ Multiplexing with DNA Exchange Imaging in Neuronal Cells and Tissues.

Heterologous erythromycin production across strain and plasmid construction.

DNA sequencing at 40: past, present and future.

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip.

A CRISPR-Cas9-based gene drive platform for genetic interaction analysis in Candida albicans.

Engineering posttranslational proofreading to discriminate nonstandard amino acids.

From Designing the Molecules of Life to Designing Life: Future Applications Derived from Advances in DNA Technologies.

Spontaneous CRISPR loci generation in vivo by non-canonical spacer integration.

Adaptive evolution of genomically recoded .

Precise Cas9 targeting enables genomic mutation prevention.

Enabling multiplexed testing of pooled donor cells through whole-genome sequencing.

An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance.

High-resolution mapping of DNA polymerase fidelity using nucleotide imbalances and next-generation sequencing.

Codon usage of highly expressed genes affects proteome-wide translation efficiency.

High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR-Cas9 in yeast.

Current CRISPR gene drive systems are likely to be highly invasive in wild populations.

Enhanced Bacterial Immunity and Mammalian Genome Editing via RNA-Polymerase-Mediated Dislodging of Cas9 from Double-Strand DNA Breaks.

Directed differentiation of human induced pluripotent stem cells into mature kidney podocytes and establishment of a Glomerulus Chip.

An enhanced CRISPR repressor for targeted mammalian gene regulation.

Biosensor libraries harness large classes of binding domains for construction of allosteric transcriptional regulators.

Developmental barcoding of whole mouse via homing CRISPR.