Department of Surgery
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Synergistic effects of hypertonic saline and valproic acid in a lethal rat two-hit model.
The journal of trauma and acute care surgery Apr, 2013 | Pubmed ID: 23511136
Novel pharmacologic treatment attenuates septic shock and improves long-term survival.
Surgery Aug, 2013 | Pubmed ID: 23889949
Valproic acid for the treatment of hemorrhagic shock: a dose-optimization study.
The Journal of surgical research Jan, 2014 | Pubmed ID: 24135375
Differential effects of fresh frozen plasma and normal saline on secondary brain damage in a large animal model of polytrauma, hemorrhage and traumatic brain injury.
The journal of trauma and acute care surgery Dec, 2013 | Pubmed ID: 24256668
Creating a prosurvival phenotype through a histone deacetylase inhibitor in a lethal two-hit model.
Shock (Augusta, Ga.) Feb, 2014 | Pubmed ID: 24430491
Selective inhibition of histone deacetylase 6 alters the composition of circulating blood cells in a lethal septic model.
The Journal of surgical research Aug, 2014 | Pubmed ID: 24613069
Selective histone deacetylase-6 inhibition attenuates stress responses and prevents immune organ atrophy in a lethal septic model.
Surgery Aug, 2014 | Pubmed ID: 24947640
Histone deacetylase inhibitor treatment attenuates coagulation imbalance in a lethal murine model of sepsis.
Surgery Aug, 2014 | Pubmed ID: 24957668
Citrullinated histone H3: a novel target for the treatment of sepsis.
Surgery Aug, 2014 | Pubmed ID: 24957671
Effect of pharmacologic resuscitation on the brain gene expression profiles in a swine model of traumatic brain injury and hemorrhage.
The journal of trauma and acute care surgery Dec, 2014 | Pubmed ID: 25051383
Histone deacetylase III as a potential therapeutic target for the treatment of lethal sepsis.
The journal of trauma and acute care surgery Dec, 2014 | Pubmed ID: 25051385
Histone cleavage as a mechanism for epigenetic regulation: current insights and perspectives.
Current molecular medicine , 2014 | Pubmed ID: 25323999
Protective effect of suberoylanilide hydroxamic acid against lipopolysaccharide-induced liver damage in rodents.
The Journal of surgical research Apr, 2015 | Pubmed ID: 25479907
Creating a "Prosurvival Phenotype" Through Histone Deacetylase Inhibition: Past, Present, and Future.
Shock (Augusta, Ga.) Aug, 2015 | Pubmed ID: 25565645
Inhibition of histone deacetylase 6 improves long-term survival in a lethal septic model.
The journal of trauma and acute care surgery Feb, 2015 | Pubmed ID: 25757125
Hypothermia and valproic acid activate prosurvival pathways after hemorrhage.
The Journal of surgical research Jun, 2015 | Pubmed ID: 25777823
Selective histone deacetylase 6 inhibition prolongs survival in a lethal two-hit model.
The Journal of surgical research Jul, 2015 | Pubmed ID: 25837686
Early resuscitation with fresh frozen plasma for traumatic brain injury combined with hemorrhagic shock improves neurologic recovery.
Journal of the American College of Surgeons May, 2015 | Pubmed ID: 25907868
Inhibition of peptidylarginine deiminase attenuates inflammation and improves survival in a rat model of hemorrhagic shock.
The Journal of surgical research Feb, 2016 | Pubmed ID: 26434505
Inhibition of histone deacetylase 6 restores innate immune cells in the bone marrow in a lethal septic model.
The journal of trauma and acute care surgery Jan, 2016 | Pubmed ID: 26491797
Selective inhibition of histone deacetylase 6 promotes survival in a rat model of hemorrhagic shock.
The journal of trauma and acute care surgery Dec, 2015 | Pubmed ID: 26680133
Addition of low-dose valproic acid to saline resuscitation provides neuroprotection and improves long-term outcomes in a large animal model of combined traumatic brain injury and hemorrhagic shock.
The journal of trauma and acute care surgery Dec, 2015 | Pubmed ID: 26680134
Resuscitation with Valproic Acid Alters Inflammatory Genes in a Porcine Model of Combined Traumatic Brain Injury and Hemorrhagic Shock.
Journal of neurotrauma Aug, 2016 | Pubmed ID: 26905959
Inhibition of histone deacetylase 6 restores intestinal tight junction in hemorrhagic shock.
The journal of trauma and acute care surgery 09, 2016 | Pubmed ID: 27257709
Alterations in the human proteome following administration of valproic acid.
The journal of trauma and acute care surgery 12, 2016 | Pubmed ID: 27602906
The Effects of Molecular Hydrogen and Suberoylanilide Hydroxamic Acid on Paraquat-Induced Production of Reactive Oxygen Species and TNF-α in Macrophages.
Inflammation Dec, 2016 | Pubmed ID: 27624060
Fresh Frozen Plasma Modulates Brain Gene Expression in a Swine Model of Traumatic Brain Injury and Shock: A Network Analysis.
Journal of the American College of Surgeons Jan, 2017 | Pubmed ID: 27725221
Protective effect of Cl-amidine against CLP-induced lethal septic shock in mice.
Scientific reports 11, 2016 | Pubmed ID: 27819302
Early resuscitation with lyophilized plasma provides equal neuroprotection compared with fresh frozen plasma in a large animal survival model of traumatic brain injury and hemorrhagic shock.
The journal of trauma and acute care surgery 12, 2016 | Pubmed ID: 27893618
Resuscitation with Lyophilized Plasma Is Safe and Improves Neurological Recovery in a Long-Term Survival Model of Swine Subjected to Traumatic Brain Injury, Hemorrhagic Shock, and Polytrauma.
Journal of neurotrauma Jul, 2017 | Pubmed ID: 28228060
Valproic acid modulates platelet and coagulation function ex vivo.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis Sep, 2017 | Pubmed ID: 28230635
Lung Protective Effects of Low-Volume Resuscitation and Pharmacologic Treatment of Swine Subjected to Polytrauma and Hemorrhagic Shock.
Inflammation Aug, 2017 | Pubmed ID: 28493077
Valproic acid decreases brain lesion size and improves neurologic recovery in swine subjected to traumatic brain injury, hemorrhagic shock, and polytrauma.
The journal of trauma and acute care surgery Dec, 2017 | Pubmed ID: 28697014
CitH3: a reliable blood biomarker for diagnosis and treatment of endotoxic shock.
Scientific reports Aug, 2017 | Pubmed ID: 28827548
Transfusion Strategies are Associated with Epigenetic Changes Following Blunt Trauma.
Shock (Augusta, Ga.) Jul, 2018 | Pubmed ID: 29059104
Tubastatin A prevents hemorrhage-induced endothelial barrier dysfunction.
The journal of trauma and acute care surgery Feb, 2018 | Pubmed ID: 29194316
Histone deacetylase inhibitors: Isoform selectivity improves survival in a hemorrhagic shock model.
The journal of trauma and acute care surgery May, 2018 | Pubmed ID: 29401190
Inhibition of peptidylarginine deiminase alleviates LPS-induced pulmonary dysfunction and improves survival in a mouse model of lethal endotoxemia.
European journal of pharmacology Aug, 2018 | Pubmed ID: 29981294
Protective Effect of Tubastatin A in CLP-Induced Lethal Sepsis.
Inflammation Jul, 2018 | Pubmed ID: 30047002
Aaron M. Williams*,1,
Umar F. Bhatti*,1,
Isabel S. Dennahy1,
Kiril Chtraklin1,
Panpan Chang1,
Nathan J. Graham1,
Basil M. Baccouche1,
Shalini Roy1,
Mohammed Harajli1,
Jing Zhou1,
Vahagn C. Nikolian1,
Qiufang Deng1,
Yuzi Tian1,
Baoling Liu1,
Yongqing Li1,
Gregory L. Hays1,2,
Julia L. Hays1,2,
Hasan B. Alam1
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