Bernhard Wehrle-Haller

Alpha-smooth muscle actin is crucial for focal adhesion maturation in myofibroblasts.

Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy.

Analysis of integrin dynamics by fluorescence recovery after photobleaching.

Dimerization of Kit-ligand and efficient cell-surface presentation requires a conserved Ser-Gly-Gly-Tyr motif in its transmembrane domain.

New PI(4,5)P2- and membrane proximal integrin-binding motifs in the talin head control beta3-integrin clustering.

Integrins: versatile receptors controlling melanocyte adhesion, migration and proliferation.

Structure and function of focal adhesions.

Novel mechanistic link between focal adhesion remodeling and glucose-stimulated insulin secretion.

Membrane-bound Kit ligand regulates melanocyte adhesion and survival, providing physical interaction with an intraepithelial niche.

Assembly and disassembly of cell matrix adhesions.

Talin-bound NPLY motif recruits integrin-signaling adapters to regulate cell spreading and mechanosensing.

Niche anchorage and signaling through membrane-bound Kit-ligand/c-kit receptor are kinase independent and imatinib insensitive.

Maturation of filopodia shaft adhesions is upregulated by local cycles of lamellipodia advancements and retractions.

Plasticity of the actin cytoskeleton in response to extracellular matrix nanostructure and dimensionality.

Intracellular signaling and perception of neuronal scaffold through integrins and their adapter proteins.

Cytoplasmic methylation fuels leukocyte invasion.

Mechanosensing in cell-matrix adhesions - Converting tension into chemical signals.

Astrocytes spatially restrict VEGF signaling by polarized secretion and incorporation of VEGF into the actively assembling extracellular matrix.

Role and impact of the extracellular matrix on integrin-mediated pancreatic β-cell functions.

Mechanical stability of talin rod controls cell migration and substrate sensing.

β1 integrin-dependent Rac/group I PAK signaling mediates YAP activation of Yes-associated protein 1 (YAP1) via NF2/merlin.