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Anesthesiology Department
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Etomidate increases mortality in septic rats through inhibition of nuclear factor kappa-B rather than by causing adrenal insufficiency.
The Journal of surgical research Jan, 2015 | Pubmed ID: 25103639
Pretreatment with low dose etomidate prevents etomidate-induced rat adrenal insufficiency by regulating oxidative stress-related MAPKs and apoptosis.
Environmental toxicology and pharmacology May, 2015 | Pubmed ID: 25989534
Etomidate Mitigates Lipopolysaccharide-Induced CD14 and TREM-1 Expression, NF-κB Activation, and Pro-inflammatory Cytokine Production in Rat Macrophages.
Inflammation Feb, 2016 | Pubmed ID: 26383906
The pituitary adenylate cyclase-activating polypeptide (PACAP) protects adrenal function in septic rats administered etomidate.
Neuropeptides Aug, 2016 | Pubmed ID: 27103538
Etomidate inhibits nuclear factor-κB through decreased expression of glucocorticoid receptor in septic rats.
Molecular medicine reports Dec, 2016 | Pubmed ID: 27878281
The second hospital of Dalian Medical University
Yu Zhang *,1,
Guan Wang*,1,
Jia Lu1,
Li-ming Xu2,
Jun-yu Xiong1
1Anesthesiology Department, The Second Hospital of Dalian Medical University,
2Scientific Research Center, The Second Hospital of Dalian Medical University
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