MRC Molecular Haematology Unit,
MRC Weatherall Institute of Molecular Medicine,
John Radcliffe Hospital,
MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital
Dr Rui Monteiro is a BHF Intermediate Basic Science Research Fellow and Birmingham Fellow at the University of Birmingham, UK. He graduated in Biochemistry from the University of Lisbon, Portugal and earned his PhD in Developmental Biology with Prof Christine Mummery at the Hubrecht Institute in Utrecht, The Netherlands.
During his PhD he developed a keen interest in the TGF/BMP signalling pathway. There, he generated transgenic reporters in mice to map BMP activity during embryonic development in mice and also identified the two zebrafish BMP type II receptors required for left-right asymmetry. In 2006, he joined Profr Roger Patient’s lab at the Weatherall Institute, University of Oxford to learn about developmental haematopoiesis and transcriptional regulation of cell fate decisions.
Dr Monteiro received a BHF Intermediate Basic Science Fellowship in 2014 to establish his own research group in the Radcliffe Department of Medicine at the University of Oxford, investigating TGF signalling and its role in the formation on blood stem cells. In 2016 he became a University Research Lecturer at Oxford and in 2018 he was recruited as faculty at the Institute of Cancer and Genomic Sciences, University of Birmingham. His lab research programme is focussed on the study of transcription factors and DNA elements (enhancers) that function to establish the genetic programming of haemogenic endothelial cells and blood stem cells, both in development and in disease.
A novel complex, RUNX1-MYEF2, represses hematopoietic genes in erythroid cells.
Molecular and cellular biology Oct, 2012 | Pubmed ID: 22801375
Analysis of Dll4 regulation reveals a combinatorial role for Sox and Notch in arterial development.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2013 | Pubmed ID: 23818617
Developmental hematopoiesis: ontogeny, genetic programming and conservation.
Experimental hematology Aug, 2014 | Pubmed ID: 24950425
A novel TGFβ modulator that uncouples R-Smad/I-Smad-mediated negative feedback from R-Smad/ligand-driven positive feedback.
PLoS biology Feb, 2015 | Pubmed ID: 25665164
BMP and Hedgehog Regulate Distinct AGM Hematopoietic Stem Cells Ex Vivo.
Stem cell reports Mar, 2016 | Pubmed ID: 26923823
Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells.
Developmental cell 08, 2016 | Pubmed ID: 27499523
Report of the 4th European Zebrafish Principal Investigator Meeting.
Zebrafish 12, 2016 | Pubmed ID: 27626600
An optimised pipeline for parallel image-based quantification of gene expression and genotyping after hybridisation.
Biology open Apr, 2018 | Pubmed ID: 29535102
Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium.
Nature communications 08, 2019 | Pubmed ID: 31395869
The roles and controls of GATA factors in blood and cardiac development.
IUBMB life 01, 2020 | Pubmed ID: 31778014
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