Anders Nykjaer

Pathways for kidney-specific uptake of the steroid hormone 25-hydroxyvitamin D3.

The low-density lipoprotein receptor gene family: a cellular Swiss army knife?

Expression profiling confirms the role of endocytic receptor megalin in renal vitamin D3 metabolism.

低钙血症和肾特定 megalin 基因小鼠骨病缺损。

From holoprosencephaly to osteopathology: role of multifunctional endocytic receptors in absorptive epithelia.

Sortilin is essential for proNGF-induced neuronal cell death.

The mosaic receptor sorLA/LR11 binds components of the plasminogen-activating system and platelet-derived growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand.

Functional organization of the sortilin Vps10p domain.

p75NTR--live or let die.

ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin.

Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway.

Role of endocytosis in cellular uptake of sex steroids.

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.

Tumour necrosis factor alpha-converting enzyme mediates ectodomain shedding of Vps10p-domain receptor family members.

Hyporesponsiveness to glucocorticoids in mice genetically deficient for the corticosteroid binding globulin.

Inhibition of PDGF-BB by Factor VII-activating protease (FSAP) is neutralized by protease nexin-1, and the FSAP-inhibitor complexes are internalized via LRP.

Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.

Different motifs regulate trafficking of SorCS1 isoforms.

VPS10P-domain receptors - regulators of neuronal viability and function.

Cubilin and megalin co-localize in the neonatal inner ear.

Assessing low-dose gentamicin-induced kidney injury in rats by analysis of urine.

Cellular uptake of steroid carrier proteins--mechanisms and implications.

Mature BDNF, but not proBDNF, reduces excitability of fast-spiking interneurons in mouse dentate gyrus.

Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression.

Preservation of cortical sortilin protein levels in MCI and Alzheimer's disease.

Identification of a linear epitope in sortilin that partakes in pro-neurotrophin binding.

SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2.

Golgi-to-phagosome transport of acid sphingomyelinase and prosaposin is mediated by sortilin.

Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export.

APP involvement in retinogenesis of mice.

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.

Sortilins: new players in lipoprotein metabolism.

Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons.

SorLA regulates the activity of lipoprotein lipase by intracellular trafficking.

Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?: Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75(NTR).

Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation.

Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease.

Retromer Binds the FANSHY Sorting Motif in SorLA to Regulate Amyloid Precursor Protein Sorting and Processing.

The Loop Diuretic Bumetanide Blocks Posttraumatic p75NTR Upregulation and Rescues Injured Neurons.