Robert W. O'Rourke
Department of Surgery
University of Michigan Medical School
Dr. O'Rourke serves as Professor in the Division of Minimally Invasive Surgery at Michigan Medicine and the Ann Arbor Veterans Healthcare System, and as Chief of the Division of General Surgery and Director of the Bariatric Surgery Program at the Ann Arbor Veterans Affairs Healthcare System. He graduated from the Massachusetts Institute of Technology in Cambridge, MA in 1986 with degrees in Chemical Engineering and Molecular Biology, obtained his MD in 1993 from the UCLA Medical School in Los Angeles, CA, and completed his general surgery residency training in 2001 at UCSF in San Francisco, CA. He completed an Advanced Minimally Invasive Surgery Fellowship in 2003 at Legacy Health Systems in Portland, OR. Dr. O'Rourke joined the faculty at the University of Michigan Health System in 2013, after ten years as a faculty member in the Department of Surgery at Oregon Health & Science University in Portland, OR. He has spent the last 6 years practicing clinical general and bariatric surgery at the Ann Arbor VA Hospital. Dr. O'Rourke has managed an NIH-funded research program for the past 16 years that studies molecular and cellular mechanisms of adipose tissue dysfunction in the context of metabolic disease.
Obesity heats up adipose tissue lymphocytes.
Gastroenterology Aug, 2013 | Pubmed ID: 23806542
Systemic NK cell ablation attenuates intra-abdominal adipose tissue macrophage infiltration in murine obesity.
Obesity (Silver Spring, Md.) Oct, 2014 | Pubmed ID: 24962029
Endometrial hyperplasia, endometrial cancer, and obesity: convergent mechanisms regulating energy homeostasis and cellular proliferation.
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery Sep-Oct, 2014 | Pubmed ID: 25205568
Obesity and cancer: at the crossroads of cellular metabolism and proliferation.
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery Nov-Dec, 2014 | Pubmed ID: 25264328
An MHC II-dependent activation loop between adipose tissue macrophages and CD4+ T cells controls obesity-induced inflammation.
Cell reports Oct, 2014 | Pubmed ID: 25310975
CD40 promotes MHC class II expression on adipose tissue macrophages and regulates adipose tissue CD4+ T cells with obesity.
Journal of leukocyte biology 06, 2016 | Pubmed ID: 26658005
Adipose tissue fibrosis, hypertrophy, and hyperplasia: Correlations with diabetes in human obesity.
Obesity (Silver Spring, Md.) Mar, 2016 | Pubmed ID: 26916240
Adipocytes promote pancreatic cancer cell proliferation via glutamine transfer.
Biochemistry and biophysics reports Sep, 2016 | Pubmed ID: 27617308
Adipose Tissue Dendritic Cells Are Independent Contributors to Obesity-Induced Inflammation and Insulin Resistance.
Journal of immunology (Baltimore, Md. : 1950) 11, 2016 | Pubmed ID: 27683748
Diabetes-Specific Regulation of Adipocyte Metabolism by the Adipose Tissue Extracellular Matrix.
The Journal of clinical endocrinology and metabolism 03, 2017 | Pubmed ID: 28359093
Adipocyte hypertrophy-hyperplasia balance contributes to weight loss after bariatric surgery.
Adipocyte 04, 2017 | Pubmed ID: 28425841
Frontline Science: Rapid adipose tissue expansion triggers unique proliferation and lipid accumulation profiles in adipose tissue macrophages.
Journal of leukocyte biology 04, 2018 | Pubmed ID: 29493813
Serum biomarkers of inflammation and adiposity in the LABS cohort: associations with metabolic disease and surgical outcomes.
International journal of obesity (2005) 02, 2019 | Pubmed ID: 29777230
Adipose tissue and the physiologic underpinnings of metabolic disease.
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 11, 2018 | Pubmed ID: 30193906
GM-CSF Administration Improves Defects in Innate Immunity and Sepsis Survival in Obese Diabetic Mice.
Journal of immunology (Baltimore, Md. : 1950) 02, 2019 | Pubmed ID: 30578307
A Human 3D Extracellular Matrix-Adipocyte Culture Model for Studying Matrix-Cell Metabolic Crosstalk
Carmen G. Flesher1,
Nicki A. Baker1,
Clarissa Strieder-Barboza1,2,
Dominic Polsinelli5,
Phillip J. Webster1,2,
Oliver A. Varban1,
Carey N. Lumeng2,3,4,
Robert W. O'Rourke1,6
1Department of Surgery, University of Michigan Medical School,
2Department of Pediatrics and Communicable Diseases, University of Michigan Medical School,
3Graduate Program in Immunology, University of Michigan Medical School,
4Graduate Program in Cellular and Molecular Biology, University of Michigan Medical School,
5Undergraduate Research Opportunity Program, University of Michigan,
6Department of Surgery, Ann Arbor Veterans Affairs Healthcare System
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