Centre for Superbug Solutions,
Institute for Molecular Biosciences,
Centre for Superbug Solutions, Institute for Molecular Biosciences
Dr Mark Blaskovich is an antibiotic hunter based at the Centre for Superbug Solutions in the Institute for Molecular Bioscience at The University of Queensland. A medicinal chemist with 15 years of industrial drug development experience prior to his academic career, Mark has been developing new antibiotics to treat drug resistant pathogens and using modified antibiotics to detect bacterial infections. He is a cofounder of the Community for Open Antimicrobial Drug Discovery, a global antibiotic discovery initiative, and has led a number of UQ-industry collaborations focused on antibiotic development. An inventor on eleven patent families, Mark has developed drugs in clinical trials, published more than eighty research articles, and received over $10m in grant funding.
Drug discovery and protein tyrosine phosphatases.
Current medicinal chemistry , 2009 | Pubmed ID: 19519384
An azido-oxazolidinone antibiotic for live bacterial cell imaging and generation of antibiotic variants.
Bioorganic & medicinal chemistry Aug, 2014 | Pubmed ID: 25023540
Glycopeptide antibiotics: back to the future.
The Journal of antibiotics Sep, 2014 | Pubmed ID: 25118105
Metronidazole-triazole conjugates: activity against Clostridium difficile and parasites.
European journal of medicinal chemistry Aug, 2015 | Pubmed ID: 26117821
Mucin Binding Reduces Colistin Antimicrobial Activity.
Antimicrobial agents and chemotherapy Oct, 2015 | Pubmed ID: 26169405
Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B.
Journal of medicinal chemistry Feb, 2016 | Pubmed ID: 26734854
Short cationic lipopeptides as effective antibacterial agents: Design, physicochemical properties and biological evaluation.
Bioorganic & medicinal chemistry 05, 2016 | Pubmed ID: 27048775
Contribution of Amphipathicity and Hydrophobicity to the Antimicrobial Activity and Cytotoxicity of β-Hairpin Peptides.
ACS infectious diseases Jun, 2016 | Pubmed ID: 27331141
Unusual Amino Acids in Medicinal Chemistry.
Journal of medicinal chemistry 12, 2016 | Pubmed ID: 27589349
Helping Chemists Discover New Antibiotics.
ACS infectious diseases Jul, 2015 | Pubmed ID: 27622818
Fluorescent Trimethoprim Conjugate Probes To Assess Drug Accumulation in Wild Type and Mutant Escherichia coli.
ACS infectious diseases 10, 2016 | Pubmed ID: 27737551
Surface Ligand Density of Antibiotic-Nanoparticle Conjugates Enhances Target Avidity and Membrane Permeabilization of Vancomycin-Resistant Bacteria.
Bioconjugate chemistry 02, 2017 | Pubmed ID: 27959504
Enhancement of antibiotic-activity through complexation with metal ions - Combined ITC, NMR, enzymatic and biological studies.
Journal of inorganic biochemistry 02, 2017 | Pubmed ID: 27984786
Polishing the tarnished silver bullet: the quest for new antibiotics.
Essays in biochemistry 02, 2017 | Pubmed ID: 28258234
Nitroimidazoles: Molecular Fireworks That Combat a Broad Spectrum of Infectious Diseases.
Journal of medicinal chemistry 09, 2017 | Pubmed ID: 28463485
Investigating the Interaction of Octapeptin A3 with Model Bacterial Membranes.
ACS infectious diseases Aug, 2017 | Pubmed ID: 28695731
Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1.
ACS infectious diseases 12, 2017 | Pubmed ID: 28960954
Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria.
Nature communications 01, 2018 | Pubmed ID: 29295973
Developments in Glycopeptide Antibiotics.
ACS infectious diseases 05, 2018 | Pubmed ID: 29363950
Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria.
Cell chemical biology 04, 2018 | Pubmed ID: 29396290
Multifactorial chromosomal variants regulate polymyxin resistance in extensively drug-resistant Klebsiella pneumoniae.
Microbial genomics 03, 2018 | Pubmed ID: 29431605
Fluorescent Antibiotics: New Research Tools to Fight Antibiotic Resistance.
Trends in biotechnology 05, 2018 | Pubmed ID: 29478675
The Fight Against Antimicrobial Resistance Is Confounded by a Global Increase in Antibiotic Usage.
ACS infectious diseases 06, 2018 | Pubmed ID: 29757608
Silver bullets: A new lustre on an old antimicrobial agent.
Biotechnology advances Sep - Oct, 2018 | Pubmed ID: 29847770
Can octapeptin antibiotics combat extensively drug-resistant (XDR) bacteria?
Expert review of anti-infective therapy 06, 2018 | Pubmed ID: 29848132
Detection and Investigation of Eagle Effect Resistance to Vancomycin in With an ATP-Bioluminescence Assay.
Frontiers in microbiology , 2018 | Pubmed ID: 30013531
Antimicrobial Silver in Medicinal and Consumer Applications: A Patent Review of the Past Decade (2007⁻2017).
Antibiotics (Basel, Switzerland) Oct, 2018 | Pubmed ID: 30373130
Effects of Microplate Type and Broth Additives on Microdilution MIC Susceptibility Assays.
Antimicrobial agents and chemotherapy 01, 2019 | Pubmed ID: 30397070
The Eagle Effect and Antibiotic-Induced Persistence: Two Sides of the Same Coin?
Trends in microbiology Apr, 2019 | Pubmed ID: 30448198
Design, Synthesis, and Biological Evaluation of 2-Nitroimidazopyrazin-one/-es with Antitubercular and Antiparasitic Activity.
Journal of medicinal chemistry 12, 2018 | Pubmed ID: 30468386
Structure-Function Studies of Polymyxin B Lipononapeptides.
Molecules (Basel, Switzerland) Feb, 2019 | Pubmed ID: 30717415
Elucidating the Lipid Binding Properties of Membrane-Active Peptides Using Cyclised Nanodiscs.
Frontiers in chemistry , 2019 | Pubmed ID: 31058133
Fluoroquinolone-derived fluorescent probes for studies of bacterial penetration and efflux.
MedChemComm Jun, 2019 | Pubmed ID: 31303987
In vitro Antimicrobial Activity of Acne Drugs Against Skin-Associated Bacteria.
Scientific reports Oct, 2019 | Pubmed ID: 31601845
Non-antibiotic Small-Molecule Regulation of DHFR-Based Destabilizing Domains .
Molecular therapy. Methods & clinical development Dec, 2019 | Pubmed ID: 31649953
Hydroxyl substituted benzoic acid/cinnamic acid derivatives: Tyrosinase inhibitory kinetics, anti-melanogenic activity and molecular docking studies.
Bioorganic & medicinal chemistry letters Jan, 2020 | Pubmed ID: 31732410
Light-Activated Rhenium Complexes with Dual Mode of Action against Bacteria.
Chemistry (Weinheim an der Bergstrasse, Germany) Dec, 2019 | Pubmed ID: 31788867
Quinolone antibiotics.
MedChemComm Oct, 2019 | Pubmed ID: 31803393
Tyrosinase inhibitors as potential antibacterial agents.
European journal of medicinal chemistry Feb, 2020 | Pubmed ID: 31810785
Solid-Phase Synthesis of Octapeptin Lipopeptides.
Methods in molecular biology (Clifton, N.J.) , 2020 | Pubmed ID: 31879927
Evaluating the genome and resistome of extensively drug-resistant Klebsiella pneumoniae using native DNA and RNA Nanopore sequencing.
GigaScience Feb, 2020 | Pubmed ID: 32016399
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