Department of Biomedical Engineering,
Molecular Imaging Center,
Research Center for Developmental Biology and Regenerative Medicine
Dr. Sung-Jan Lin is the Taiwan Bio-development Foundation (TBF) Chair in Biotechnology and Professor of Institute of Biomedical Engineering and the Deputy Director of Research Center for Developmental Biology and Regenerative Medicine at National Taiwan University. He is also a dermatologist in National Taiwan University Hospital. He received his MD and PhD from College of Medicine and College of Engineering in National Taiwan University. He takes hair follicles, a miniorgan with distinct structures and growth cycles, as a model to understand how a complex organ interacts with the environment and reacts to various insults and to decipher the principles and machinery of tissue regeneration. His lab employs a multidisciplinary approach by combing the knowledge learned in biology and tissue engineering to enhance tissue regeneration. He has published ~140 journal papers in associated journals, including Cell, Science, PNAS, Nature Communications, Biomaterials, Optics Letters, etc. His work has been recognized by Award for Junior Research Investigators in Life Science of Academia Sinica, Physician Scientist Award of Taiwan National Health Research Institutes, Distinguished Research Award of Taiwan Ministry of Science and Technology and Outstanding Professor Award of Far Eastern Y.Z. Hsu Science and Technology Memorial Foundation. In 2014, he was elected as Taiwan Bio-development Foundation (TBF) Chair in Biotechnology.
HLA-Cw6 specificity and polymorphic residues are associated with susceptibility among Chinese psoriatics in Taiwan.
Archives of dermatological research Jul, 2002 | Pubmed ID: 12115024
An asymptomatic preauricular subcutaneous nodule in a 65-year-old woman.
Archives of dermatology Mar, 2003 | Pubmed ID: 12622641
Multiphoton polarization and generalized polarization microscopy reveal oleic-acid-induced structural changes in intercellular lipid layers of the skin.
Optics letters Sep, 2004 | Pubmed ID: 15455764
Formation of melanocyte spheroids on the chitosan-coated surface.
Biomaterials Apr, 2005 | Pubmed ID: 15482829
Effects of objective numerical apertures on achievable imaging depths in multiphoton microscopy.
Microscopy research and technique Dec, 2004 | Pubmed ID: 15662621
Monitoring the thermally induced structural transitions of collagen by use of second-harmonic generation microscopy.
Optics letters Mar, 2005 | Pubmed ID: 15791996
Enhanced cell survival of melanocyte spheroids in serum starvation condition.
Biomaterials Mar, 2006 | Pubmed ID: 16171860
A cervical congenital atrophic band with a nipplelike projection.
Archives of dermatology Sep, 2005 | Pubmed ID: 16172320
Evaluating cutaneous photoaging by use of multiphoton fluorescence and second-harmonic generation microscopy.
Optics letters Sep, 2005 | Pubmed ID: 16190442
Multiphoton autofluorescence and second-harmonic generation imaging of the ex vivo porcine eye.
Investigative ophthalmology & visual science Mar, 2006 | Pubmed ID: 16505061
Cyclooxygenase-2 overexpression in human basal cell carcinoma cell line increases antiapoptosis, angiogenesis, and tumorigenesis.
The Journal of investigative dermatology May, 2006 | Pubmed ID: 16528365
Study on the effects of nylon-chitosan-blended membranes on the spheroid-forming activity of human melanocytes.
Biomaterials Oct, 2006 | Pubmed ID: 16777216
Prediction of heat-induced collagen shrinkage by use of second harmonic generation microscopy.
Journal of biomedical optics May-Jun, 2006 | Pubmed ID: 16822069
Investigating mechanisms of collagen thermal denaturation by high resolution second-harmonic generation imaging.
Biophysical journal Oct, 2006 | Pubmed ID: 16829565
Discrimination of basal cell carcinoma from normal dermal stroma by quantitative multiphoton imaging.
Optics letters Sep, 2006 | Pubmed ID: 16936882
Effects of different immersion media in multiphoton imaging of the epithelium and dermis of human skin.
Microscopy research and technique Dec, 2006 | Pubmed ID: 16981195
Evaluation of dermal thermal damage by multiphoton autofluorescence and second-harmonic-generation microscopy.
Journal of biomedical optics Nov-Dec, 2006 | Pubmed ID: 17212529
Multiphoton fluorescence and second-harmonic-generation microscopy for imaging structural alterations in corneal scar tissue in penetrating full-thickness wound.
Archives of ophthalmology (Chicago, Ill. : 1960) Jul, 2007 | Pubmed ID: 17620585
Multiphoton microscopy: a new paradigm in dermatological imaging.
European journal of dermatology : EJD Sep-Oct, 2007 | Pubmed ID: 17673377
Imaging tissue engineering scaffolds using multiphoton microscopy.
Microscopy research and technique Feb, 2008 | Pubmed ID: 17943985
Polarization ellipticity compensation in polarization second-harmonic generation microscopy without specimen rotation.
Journal of biomedical optics Jan-Feb, 2008 | Pubmed ID: 18315363
The effects of depilatory agents as penetration enhancers on human stratum corneum structures.
The Journal of investigative dermatology Sep, 2008 | Pubmed ID: 18401425
Self-assembly of dermal papilla cells into inductive spheroidal microtissues on poly(ethylene-co-vinyl alcohol) membranes for hair follicle regeneration.
Biomaterials Sep, 2008 | Pubmed ID: 18533254
Characterizing phase-separated microstructure of polymeric blended membrane using combined multiphoton and reflected confocal imaging.
Optics express Mar, 2008 | Pubmed ID: 18542477
Tumor-associated macrophage-induced invasion and angiogenesis of human basal cell carcinoma cells by cyclooxygenase-2 induction.
The Journal of investigative dermatology Apr, 2009 | Pubmed ID: 18843292
Label-free imaging of Drosophila larva by multiphoton autofluorescence and second harmonic generation microscopy.
Journal of biomedical optics Sep-Oct, 2008 | Pubmed ID: 19021374
Discrimination of collagen in normal and pathological skin dermis through second-order susceptibility microscopy.
Optics express Jun, 2009 | Pubmed ID: 19550516
The enhancement of dermal papilla cell aggregation by extracellular matrix proteins through effects on cell-substratum adhesivity and cell motility.
Biomaterials Oct, 2009 | Pubmed ID: 19556003
Clinical images: Infestation by Norwegian scabies.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne Sep, 2009 | Pubmed ID: 19620272
Differentiation of normal and cancerous lung tissues by multiphoton imaging.
Journal of biomedical optics Jul-Aug, 2009 | Pubmed ID: 19725745
Biomaterial mediated epithelial-mesenchymal interaction of salivary tissue under serum free condition.
Biomaterials Jan, 2010 | Pubmed ID: 19853295
Single-wavelength reflected confocal and multiphoton microscopy for tissue imaging.
Journal of biomedical optics Sep-Oct, 2009 | Pubmed ID: 19895128
High-throughput reconstitution of epithelial-mesenchymal interaction in folliculoid microtissues by biomaterial-facilitated self-assembly of dissociated heterotypic adult cells.
Biomaterials May, 2010 | Pubmed ID: 20206989
Factors from human embryonic stem cell-derived fibroblast-like cells promote topology-dependent hepatic differentiation in primate embryonic and induced pluripotent stem cells.
The Journal of biological chemistry Oct, 2010 | Pubmed ID: 20720011
Images in clinical medicine. Serpentine supravenous hyperpigmentation.
The New England journal of medicine Jul, 2010 | Pubmed ID: 20830826
In search of the Golden Fleece: unraveling principles of morphogenesis by studying the integrative biology of skin appendages.
Integrative biology : quantitative biosciences from nano to macro Apr, 2011 | Pubmed ID: 21437328
Images in clinical medicine: Porphyria cutanea tarda.
The New England journal of medicine Sep, 2011 | Pubmed ID: 21992125
Toward the isolation and culture of melanocyte stem cells.
The Journal of investigative dermatology Dec, 2011 | Pubmed ID: 22071538
Scalable production of controllable dermal papilla spheroids on PVA surfaces and the effects of spheroid size on hair follicle regeneration.
Biomaterials Jan, 2013 | Pubmed ID: 23092862
Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering.
Expert opinion on biological therapy Mar, 2013 | Pubmed ID: 23289545
Feather regeneration as a model for organogenesis.
Development, growth & differentiation Jan, 2013 | Pubmed ID: 23294361
Inducible deletion of the Blimp-1 gene in adult epidermis causes granulocyte-dominated chronic skin inflammation in mice.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2013 | Pubmed ID: 23576729
A painful bulge in the left flank.
JAMA Aug, 2013 | Pubmed ID: 23942683
Extensive scleredema adultorum with loss of eccrine glands.
Journal of the American Academy of Dermatology Sep, 2014 | Pubmed ID: 25128148
Red papules on the tongue of a patient with hemiparesis.
JAMA Aug, 2014 | Pubmed ID: 25138335
Visible red light enhances physiological anagen entry in vivo and has direct and indirect stimulative effects in vitro.
Lasers in surgery and medicine Jan, 2015 | Pubmed ID: 25557083
Regenerative metamorphosis in hairs and feathers: follicle as a programmable biological printer.
Experimental dermatology Apr, 2015 | Pubmed ID: 25557541
Risk Factor Analysis for the Immunogenicity of Adalimumab Associated with Decreased Clinical Response in Chinese Patients with Psoriasis.
Acta dermato-venereologica Jul, 2015 | Pubmed ID: 25673333
Enhancing hair follicle regeneration by nonablative fractional laser: Assessment of irradiation parameters and tissue response.
Lasers in surgery and medicine Apr, 2015 | Pubmed ID: 25866259
A Two-Stepped Culture Method for Efficient Production of Trichogenic Keratinocytes.
Tissue engineering. Part C, Methods Oct, 2015 | Pubmed ID: 25951188
Programmable Laser-Assisted Surface Microfabrication on a Poly(Vinyl Alcohol)-Coated Glass Chip with Self-Changing Cell Adhesivity for Heterotypic Cell Patterning.
ACS applied materials & interfaces Oct, 2015 | Pubmed ID: 26393271
Correlation of IL36RN mutation with different clinical features of pustular psoriasis in Chinese patients.
Archives of dermatological research Jan, 2016 | Pubmed ID: 26589685
ABCG2 deficiency in skin impairs re-epithelialization in cutaneous wound healing.
Experimental dermatology 05, 2016 | Pubmed ID: 26739701
Extensive cicatricial alopecia in a patient with long-term trichotillomania.
The Journal of dermatology Feb, 2016 | Pubmed ID: 26813077
Minoxidil improved hair density in an Asian girl with short anagen syndrome: a case report and review of literature.
International journal of dermatology Nov, 2016 | Pubmed ID: 27420346
Stress-induced premature senescence of dermal papilla cells compromises hair follicle epithelial-mesenchymal interaction.
Journal of dermatological science May, 2017 | Pubmed ID: 28117106
Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy.
Cancer research 11, 2017 | Pubmed ID: 28939680
Increased risk of chronic kidney disease in patients with rosacea: A nationwide population-based matched cohort study.
PloS one , 2017 | Pubmed ID: 28968402
Activation of mTORC1 Signaling is Required for Timely Hair Follicle Regeneration from Radiation Injury.
Radiation research 12, 2017 | Pubmed ID: 29019741
Preclinical evaluation of melanocyte transplantation by chitosan-based melanocyte spheroid patch to skin prepared by controlled sunburn blistering.
Journal of biomedical materials research. Part B, Applied biomaterials 10, 2018 | Pubmed ID: 29322633
Inducing hair follicle neogenesis with secreted proteins enriched in embryonic skin.
Biomaterials 06, 2018 | Pubmed ID: 29567388
Efficacy and Safety of a Low-Level Light Therapy for Androgenetic Alopecia: A 24-Week, Randomized, Double-Blind, Self-Comparison, Sham Device-Controlled Trial.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 11, 2018 | Pubmed ID: 29957664
External light activates hair follicle stem cells through eyes via an ipRGC-SCN-sympathetic neural pathway.
Proceedings of the National Academy of Sciences of the United States of America 07, 2018 | Pubmed ID: 29959210
How chemotherapy and radiotherapy damage the tissue: Comparative biology lessons from feather and hair models.
Experimental dermatology 04, 2019 | Pubmed ID: 30457678
Promotion of homology-directed DNA repair by polyamines.
Nature communications 01, 2019 | Pubmed ID: 30622262
Anagen hair follicle repair: Timely regenerative attempts from plastic extra-bulge epithelial cells.
Experimental dermatology 04, 2019 | Pubmed ID: 30664259
Intravital multiphoton microscopic imaging platform for ocular surface imaging.
Experimental eye research 05, 2019 | Pubmed ID: 30822399
Long-Term Intravital Imaging of the Cornea, Skin, and Hair Follicle by Multiphoton Microscope.
Methods in molecular biology (Clifton, N.J.) Apr, 2019 | Pubmed ID: 30969402
HSD3B1 gene polymorphism and female pattern hair loss in women with polycystic ovary syndrome.
Journal of the Formosan Medical Association = Taiwan yi zhi Aug, 2019 | Pubmed ID: 31056381
Proteomic Analysis Reveals Anti-Fibrotic Effects of Blue Light Photobiomodulation on Fibroblasts.
Lasers in surgery and medicine Apr, 2020 | Pubmed ID: 31321797
Functional complexity of hair follicle stem cell niche and therapeutic targeting of niche dysfunction for hair regeneration.
Journal of biomedical science Mar, 2020 | Pubmed ID: 32171310
1Department of Biomedical Engineering, National Taiwan University,
2Institute of Pharmacology, College of Medicine, National Taiwan University,
3Molecular Imaging Center, National Taiwan University,
4Department of Dermatology, National Taiwan University Hospital, and College of Medicine,
5Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University,
6Department of Ophthalmology, Chang Gung Memorial Hospital,
7College of Medicine, Chang Gung University
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