Department of Pharmacy,
The Faculty of Health and Medical Sciences,
Department of Pharmacy, The Faculty of Health and Medical Sciences
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hPEPT1 is responsible for uptake and transport of Gly-Sar in the human bronchial airway epithelial cell-line Calu-3.
Pflugers Archiv : European journal of physiology Jun, 2008 | Pubmed ID: 18094991
Cloning of the pig PEPT2 (pPEPT2) and characterization of the effects of epidermal growth factor (EGF) on pPEPT2-mediated peptide uptake in the renal porcine cell line LLC-PK1.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Apr, 2008 | Pubmed ID: 18295462
Discovery of ligands for the human intestinal Di-/Tripeptide transporter (hPEPT1) using a QSAR-assisted virtual screening strategy.
ChemMedChem Sep, 2009 | Pubmed ID: 19557803
In vitro cutaneous application of ISCOMs on human skin enhances delivery of hydrophobic model compounds through the stratum corneum.
The AAPS journal Dec, 2009 | Pubmed ID: 19862629
5-Hydroxy-L-tryptophan alters gaboxadol pharmacokinetics in rats: involvement of PAT1 and rOat1 in gaboxadol absorption and elimination.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Jan, 2010 | Pubmed ID: 19900542
A quantitative structure-activity relationship for translocation of tripeptides via the human proton-coupled peptide transporter, hPEPT1 (SLC15A1).
The AAPS journal Sep, 2010 | Pubmed ID: 20449699
Ibuprofen is a non-competitive inhibitor of the peptide transporter hPEPT1 (SLC15A1): possible interactions between hPEPT1 substrates and ibuprofen.
British journal of pharmacology Dec, 2010 | Pubmed ID: 20726987
Paracellular tightness and claudin-5 expression is increased in the BCEC/astrocyte blood-brain barrier model by increasing media buffer capacity during growth.
The AAPS journal Dec, 2010 | Pubmed ID: 20967520
Affinity and translocation relationships via hPEPT1 of H-X aa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V Feb, 2011 | Pubmed ID: 21147219
Calu-3 cells grown under AIC and LCC conditions: implications for dipeptide uptake and transepithelial transport of substances.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V May, 2011 | Pubmed ID: 21195173
In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells cocultured with astrocytes display a polarized brain-to-blood transport of glutamate.
Glia May, 2012 | Pubmed ID: 22392649
Carrier-mediated γ-aminobutyric acid transport across the basolateral membrane of human intestinal Caco-2 cell monolayers.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V Jun, 2012 | Pubmed ID: 22452873
In-vitro evaluation of the P-glycoprotein interactions of a series of potentially CNS-active Amaryllidaceae alkaloids.
The Journal of pharmacy and pharmacology Nov, 2012 | Pubmed ID: 23058055
Identification and Characterization of a Novel Nontranslated Sequence Variant of the Human Intestinal Di-/Tripeptide Transporter, hPEPT1.
International journal of peptides , 2012 | Pubmed ID: 23346117
Basolateral glycylsarcosine (Gly-Sar) transport in Caco-2 cell monolayers is pH dependent.
The Journal of pharmacy and pharmacology Jul, 2013 | Pubmed ID: 23738724
The absorptive flux of the anti-epileptic drug substance vigabatrin is carrier-mediated across Caco-2 cell monolayers.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Jan, 2014 | Pubmed ID: 24008184
PAT1 (SLC36A1) shows nuclear localization and affects growth of smooth muscle cells from rats.
American journal of physiology. Endocrinology and metabolism Jan, 2014 | Pubmed ID: 24222668
Generation of primary cultures of bovine brain endothelial cells and setup of cocultures with rat astrocytes.
Methods in molecular biology (Clifton, N.J.) , 2014 | Pubmed ID: 24510879
In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt-DALDA Analogues.
ACS medicinal chemistry letters Apr, 2014 | Pubmed ID: 24839540
An electrically tight in vitro blood-brain barrier model displays net brain-to-blood efflux of substrates for the ABC transporters, P-gp, Bcrp and Mrp-1.
The AAPS journal Sep, 2014 | Pubmed ID: 24934296
Glutamate efflux at the blood-brain barrier: cellular mechanisms and potential clinical relevance.
Archives of medical research Nov, 2014 | Pubmed ID: 25446623
Intestinal absorption of the antiepileptic drug substance vigabatrin is altered by infant formula in vitro and in vivo.
Pharmacology research & perspectives Apr, 2014 | Pubmed ID: 25505585
In Vitro Blood-Brain Barrier Models-An Overview of Established Models and New Microfluidic Approaches.
Journal of pharmaceutical sciences Sep, 2015 | Pubmed ID: 25630899
The putative P-gp inhibitor telmisartan does not affect the transcellular permeability and cellular uptake of the calcium channel antagonist verapamil in the P-glycoprotein expressing cell line MDCK II MDR1.
Pharmacology research & perspectives Aug, 2015 | Pubmed ID: 26171231
In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism May, 2016 | Pubmed ID: 26868179
Stroke and Drug Delivery--In Vitro Models of the Ischemic Blood-Brain Barrier.
Journal of pharmaceutical sciences Feb, 2016 | Pubmed ID: 26869407
In vitro blood-brain barrier permeability predictions for GABAA receptor modulating piperine analogs.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V Jun, 2016 | Pubmed ID: 27018328
Transferrin receptor expression and role in transendothelial transport of transferrin in cultured brain endothelial monolayers.
Molecular and cellular neurosciences Oct, 2016 | Pubmed ID: 27567687
Characterization of the L-glutamate clearance pathways across the blood-brain barrier and the effect of astrocytes in an in vitro blood-brain barrier model.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Dec, 2017 | Pubmed ID: 28145808
Bidirectional apical-basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Jul, 2017 | Pubmed ID: 28337939
A Critical View on In Vitro Analysis of P-glycoprotein (P-gp) Transport Kinetics.
Journal of pharmaceutical sciences 09, 2017 | Pubmed ID: 28438535
Routes for Drug Translocation Across the Blood-Brain Barrier: Exploiting Peptides as Delivery Vectors.
Journal of pharmaceutical sciences 09, 2017 | Pubmed ID: 28501469
Glutamate Transporters in the Blood-Brain Barrier.
Advances in neurobiology , 2017 | Pubmed ID: 28828617
Evaluating the involvement of cerebral microvascular endothelial Na/K-ATPase and Na-K-2Cl co-transporter in electrolyte fluxes in an in vitro blood-brain barrier model of dehydration.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 03, 2019 | Pubmed ID: 28994331
Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017.
Fluids and barriers of the CNS Nov, 2017 | Pubmed ID: 29110676
Characterization of the IPEC-J2 MDR1 (iP-gp) cell line as a tool for identification of P-gp substrates.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Jan, 2018 | Pubmed ID: 29146563
Correction to: Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017.
Fluids and barriers of the CNS 01, 2018 | Pubmed ID: 29329565
Data demonstrating the challenges of determining the kinetic parameters of P-gp mediated transport of low-water soluble substrates.
Data in brief Feb, 2018 | Pubmed ID: 29541662
The insulin receptor is expressed and functional in cultured blood-brain barrier endothelial cells but does not mediate insulin entry from blood to brain.
American journal of physiology. Endocrinology and metabolism 10, 2018 | Pubmed ID: 29584446
Stimulation-induced increases in cerebral blood flow and local capillary vasoconstriction depend on conducted vascular responses.
Proceedings of the National Academy of Sciences of the United States of America 06, 2018 | Pubmed ID: 29866853
Validation of reference genes for normalization of real-time quantitative PCR studies of gene expression in brain capillary endothelial cells cultured in vitro.
Molecular and cellular neurosciences 12, 2018 | Pubmed ID: 30315869
Effects of oxygen-glucose deprivation (OGD) on barrier properties and mRNA transcript levels of selected marker proteins in brain endothelial cells/astrocyte co-cultures.
PloS one , 2019 | Pubmed ID: 31425564
The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP.
Cells Mar, 2020 | Pubmed ID: 32143347
Culture-induced changes in mRNA expression levels of efflux and SLC-transporters in brain endothelial cells.
Fluids and barriers of the CNS Apr, 2020 | Pubmed ID: 32321539
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