Ronald J. Patterson
Department of Microbiology and Molecular Genetics
Michigan State University
Ronald Patterson is an emeritus professor of Microbiology and Molecular Genetics at Michigan State University. He received his PhD from Northwestern University Medical School where he studied intracellular growth of Mycobacterium tuberculosis under the tutelage of Guy Youmans. He discovered lymphocytes from immune mice secreted a substance that when added to macrophages from unimmunized mice resulted in inhibition of intracellular mycobacterial growth.
His postdoctoral training under Brian McCarthy at the University of Washington turned to the molecular aspects of determining the number of antibody genes via mRNA hybridization techniques when this was a major question in molecular genetics.
After this entry into mRNA biology, Dr Patterson took a position at Michigan State in the Department of Microbiology and studied the regulation of mRNA transport from nuclei using an in vitro isolated nuclei system. His group validated this model showing that introns of immunoglobulin genes are retained in nuclei while exons are transported.
Following a sabbatical with Thoru Pederson investigating mRNA splicing, he returned to Michigan State and initiated a long term collaboration with John Wang establishing the essential role of galectin-1 and -3 in pre-mRNA splicing. As this paper demonstrates, gal-3 is recruited to the assembling spliceosome through its association with U1 snRNP.
Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein.
Nucleic acids research Sep, 2001 | Pubmed ID: 11522829
Shuttling of galectin-3 between the nucleus and cytoplasm.
Glycobiology May, 2002 | Pubmed ID: 12070075
Understanding the biochemical activities of galectin-1 and galectin-3 in the nucleus.
Glycoconjugate journal , 2002 | Pubmed ID: 14758073
Nucleocytoplasmic lectins.
Biochimica et biophysica acta Jul, 2004 | Pubmed ID: 15238251
Transport of galectin-3 between the nucleus and cytoplasm. II. Identification of the signal for nuclear export.
Glycobiology Jul, 2006 | Pubmed ID: 16473834
Transport of galectin-3 between the nucleus and cytoplasm. I. Conditions and signals for nuclear import.
Glycobiology Jul, 2006 | Pubmed ID: 16473835
Immunoprecipitation of spliceosomal RNAs by antisera to galectin-1 and galectin-3.
Nucleic acids research , 2006 | Pubmed ID: 16998182
Distinct effects on splicing of two monoclonal antibodies directed against the amino-terminal domain of galectin-3.
Archives of biochemistry and biophysics Jul, 2008 | Pubmed ID: 18455493
Dissociation of the carbohydrate-binding and splicing activities of galectin-1.
Archives of biochemistry and biophysics Oct, 2008 | Pubmed ID: 18662664
A mechanism for incorporation of galectin-3 into the spliceosome through its association with U1 snRNP.
Biochemistry Aug, 2009 | Pubmed ID: 19603745
Dynamics of galectin-3 in the nucleus and cytoplasm.
Biochimica et biophysica acta Feb, 2010 | Pubmed ID: 19616076
SR proteins and galectins: what's in a name?
Glycobiology Oct, 2010 | Pubmed ID: 20574110
Examination of the role of galectins in pre-mRNA splicing.
Methods in molecular biology (Clifton, N.J.) , 2015 | Pubmed ID: 25253157
A 10S galectin-3-U1 snRNP complex assembles into active spliceosomes.
Nucleic acids research 07, 2016 | Pubmed ID: 27105840
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