Department of Chemistry
Dr. Wenshe Liu received his BS degree from Peking University in 2000 and his Ph.D. degree under the supervision of Dr. Michael D. Toney from University of California-Davis in 2005. Following two years of postdoctoral training in Dr. Peter G. Schultz group in the Scripps Research Institute, he started his independent research group as an assistant professor at Texas A&M University in 2007. Dr. Liu was promoted to the associate professor rank in 2013 and furthered to the full professor rank in 2016. He is currently holding the Emile and Marta Schweikert endowed professorship in the Texas A&M Chemistry Department. Dr. Liu was originally trained to work on both enzymology and protein crystallography during his Ph.D. study and later switched to organic chemistry and molecular biology during his postdoctoral training. His current research group has two operating branches. One is organic synthesis and the other is molecular and biological chemistry. The technical basis of research in Liu group is the amber suppression based noncanonical amino acid mutagenesis, targeted questions being different. One focus is to build methods for the synthesis of chromatin with specific lysine modifications for the illustration of how these modifications influence chromatin structures, interactions with transcription factors, recognition by epigenetic enzymes, and the control of other modifications in chromatin. The second focus is to develop techniques for integrating one or two noncanonical amino acids into phage displayed peptide libraries. These noncanonical amino acids serve as active chemical handles to cyclize peptide libraries, anchor enzyme/protein active sites, and expand chemical diversities of libraries by reacting with other small molecules. The ultimate goal of this research direction is to identify tight and selective inhibitors of epigenetic enzymes that can be applied for cancer treatment.
Synthesis of proteins with defined posttranslational modifications using the genetic noncanonical amino acid incorporation approach.
Molecular bioSystems Jan, 2011 | Pubmed ID: 21088799
The genetic incorporation of thirteen novel non-canonical amino acids.
Chemical communications (Cambridge, England) Mar, 2014 | Pubmed ID: 24473369
The nitrilimine-alkene cycloaddition is an ultra rapid click reaction.
Chemical communications (Cambridge, England) Mar, 2014 | Pubmed ID: 24519550
Pyrrolysyl-tRNA synthetase: an ordinary enzyme but an outstanding genetic code expansion tool.
Biochimica et biophysica acta Jun, 2014 | Pubmed ID: 24631543
A genetically encoded aldehyde for rapid protein labelling.
Chemical communications (Cambridge, England) Jul, 2014 | Pubmed ID: 24756176
Genetically encoded unstrained olefins for live cell labeling with tetrazine dyes.
Chemical communications (Cambridge, England) Nov, 2014 | Pubmed ID: 25224663
Phospha-Michael Addition as a New Click Reaction for Protein Functionalization.
Chembiochem : a European journal of chemical biology Mar, 2016 | Pubmed ID: 26756316
The "π-Clamp" Offers a New Strategy for Site-Selective Protein Modification.
Chembiochem : a European journal of chemical biology 05, 2016 | Pubmed ID: 26928847
Genetically encoded fluorophenylalanines enable insights into the recognition of lysine trimethylation by an epigenetic reader.
Chemical communications (Cambridge, England) Oct, 2016 | Pubmed ID: 27711380
Using Amber and Ochre Nonsense Codons to Code Two Different Noncanonical Amino Acids in One Protein Gene.
Methods in molecular biology (Clifton, N.J.) , 2018 | Pubmed ID: 29404996
A Click Chemistry Approach Reveals the Chromatin-Dependent Histone H3K36 Deacylase Nature of SIRT7.
Journal of the American Chemical Society 02, 2019 | Pubmed ID: 30653310
Covalent Inhibition in Drug Discovery.
ChemMedChem 05, 2019 | Pubmed ID: 30816012
A Genetically Encoded, Phage-Displayed Cyclic-Peptide Library.
Angewandte Chemie (International ed. in English) 10, 2019 | Pubmed ID: 31398275
Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV.
Chembiochem : a European journal of chemical biology 03, 2020 | Pubmed ID: 32022370
An amber obligate active site-directed ligand evolution technique for phage display.
Nature communications 03, 2020 | Pubmed ID: 32170178
Expressed Protein Ligation without Intein.
Journal of the American Chemical Society 04, 2020 | Pubmed ID: 32212692
Targeting the SARS-CoV-2 Main Protease to Repurpose Drugs for COVID-19.
bioRxiv : the preprint server for biology May, 2020 | Pubmed ID: 32511370
The molecular basis of tight nuclear tethering and inactivation of cGAS.
Nature Nov, 2020 | Pubmed ID: 32911481
An optimal "Click" formulation strategy for antibody-drug conjugate synthesis.
Bioorganic & medicinal chemistry Dec, 2020 | Pubmed ID: 33071032
A Quick Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors*.
ChemMedChem Dec, 2020 | Pubmed ID: 33283984
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