Catrin Pritchard

MEK kinase activity is not necessary for Raf-1 function.

ERK signalling and oncogene transformation are not impaired in cells lacking A-Raf.

MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma.

Expression of kinase suppressor of Ras in the normal adult and embryonic mouse.

cAMP-dependent protein kinase and Ca2+ influx through L-type voltage-gated calcium channels mediate Raf-independent activation of extracellular regulated kinase in response to glucagon-like peptide-1 in pancreatic beta-cells.

Analysis of the role of the SA gene in blood pressure regulation by gene targeting.

Raf proteins and cancer: B-Raf is identified as a mutational target.

B-Raf acts via the ROCKII/LIMK/cofilin pathway to maintain actin stress fibers in fibroblasts.

A critical function for B-Raf at multiple stages of myelopoiesis.

A-Raf and Raf-1 work together to influence transient ERK phosphorylation and Gl/S cell cycle progression.

Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts.

Mouse models for BRAF-induced cancers.

Lineage tracing of cardiac explant derived cells.

Cdx2 initiates histodifferentiation of the midgut endoderm.

CRAF autophosphorylation of serine 621 is required to prevent its proteasome-mediated degradation.

Talin 2 is a large and complex gene encoding multiple transcripts and protein isoforms.

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF.

Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.

V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a.

BRAF inactivation drives aneuploidy by deregulating CRAF.

Endothelial cell talin1 is essential for embryonic angiogenesis.

Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice.

Mechanisms of aneuploidy induction by RAS and RAF oncogenes.

Cdx2 determines the fate of postnatal intestinal endoderm.

Regulation of MEK/ERK pathway output by subcellular localization of B-Raf.

The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway.

Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile.

A new mode of RAF autoregulation: a further complication in the inhibitor paradox.

A complex secretory program orchestrated by the inflammasome controls paracrine senescence.

Hematopoietic expression of oncogenic BRAF promotes aberrant growth of monocyte-lineage cells resistant to PLX4720.

Long-term channel block is required to inhibit cellular transformation by human ether-à-go-go-related gene (hERG1) potassium channels.

Tracking genomic cancer evolution for precision medicine: the lung TRACERx study.

KRAS(G12D)-mediated oncogenic transformation of thyroid follicular cells requires long-term TSH stimulation and is regulated by SPRY1.

MGL ligand expression is correlated to BRAF mutation and associated with poor survival of stage III colon cancer patients.

The cholesterol-binding protein NPC2 restrains recruitment of stromal macrophage-lineage cells to early-stage lung tumours.

Regulation of BRAF protein stability by a negative feedback loop involving the MEK-ERK pathway but not the FBXW7 tumour suppressor.

Phosphorylations of Serines 21/9 in Glycogen Synthase Kinase 3α/β Are Not Required for Cell Lineage Commitment or WNT Signaling in the Normal Mouse Intestine.

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma.

Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development.

Explant Cultures of Non-Small Cell Lung Carcinoma Enable Evaluation of Primary Tumor Responses to Anticancer Therapy.

Attenuation Limits Progression of -Induced Papillary Thyroid Cancer Cells and Sensitizes Them to BRAF Inhibitor PLX4720.

KRAS expression in lung-resident myeloid cells promotes pulmonary LCH-like neoplasm sensitive to statin treatment.

Profiling tumour heterogeneity through circulating tumour DNA in patients with pancreatic cancer.

Over-expressed, N-terminally truncated BRAF is detected in the nucleus of cells with nuclear phosphorylated MEK and ERK.

Early detection of pre-malignant lesions in a KRAS-driven mouse lung cancer model by monitoring circulating free DNA.

Patient-derived explants, xenografts and organoids: 3-dimensional patient-relevant pre-clinical models in endometrial cancer.

Patient-derived explants (PDEs) as a powerful preclinical platform for anti-cancer drug and biomarker discovery.

DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation.

Reduced Protumorigenic Tumor-Associated Macrophages With Statin Use in Premalignant Human Lung Adenocarcinoma.

Exploration of Matrix Effects in Laser Ablation Inductively Coupled Plasma Mass Spectrometry Imaging of Cisplatin-Treated Tumors.

Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development.

Development of a patient-derived explant model for prediction of drug responses in endometrial cancer.

Evaluating and comparing immunostaining and computational methods for spatial profiling of drug response in patient-derived explants.

Ras/MAPK Dysregulation in Development Causes a Skeletal Myopathy in an Activating Braf Mouse Model for Cardio-facio-cutaneous Syndrome.

Digoxin treatment reactivates in vivo radioactive iodide uptake and correlates with favorable clinical outcome in non-medullary thyroid cancer.