Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD),
Center for Molecular Medicine Cologne
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Think locally: control of ubiquitin-dependent protein degradation in neurons.
EMBO reports Jan, 2009 | Pubmed ID: 19079132
Life and destruction: ubiquitin-mediated proteolysis in aging and longevity.
F1000 biology reports Nov, 2010 | Pubmed ID: 21151840
A screenable in vivo assay to study proteostasis networks in Caenorhabditis elegans.
Genetics Apr, 2011 | Pubmed ID: 21288877
CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication.
Molecular cell Oct, 2011 | Pubmed ID: 21981920
Analysis of ubiquitin-dependent proteolysis in Caenorhabditis elegans.
Methods in molecular biology (Clifton, N.J.) , 2012 | Pubmed ID: 22350911
Deficiency for the ubiquitin ligase UBE3B in a blepharophimosis-ptosis-intellectual-disability syndrome.
American journal of human genetics Dec, 2012 | Pubmed ID: 23200864
The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans.
Cell Jan, 2013 | Pubmed ID: 23332754
A novel interaction between aging and ER overload in a protein conformational dementia.
Genetics Mar, 2013 | Pubmed ID: 23335331
Create and preserve: proteostasis in development and aging is governed by Cdc48/p97/VCP.
Biochimica et biophysica acta Jan, 2014 | Pubmed ID: 23583830
DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance.
Nature Sep, 2013 | Pubmed ID: 23975097
Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide.
Nature chemical biology Nov, 2013 | Pubmed ID: 24077178
Hexosamine pathway metabolites enhance protein quality control and prolong life.
Cell Mar, 2014 | Pubmed ID: 24630720
Ubiquitin sets the timer: impacts on aging and longevity.
Nature structural & molecular biology Apr, 2014 | Pubmed ID: 24699075
Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system.
Cell metabolism Apr, 2014 | Pubmed ID: 24703696
Activation of the endoplasmic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2014 | Pubmed ID: 24843123
Reversible 26S proteasome disassembly upon mitochondrial stress.
Cell reports Jun, 2014 | Pubmed ID: 24857655
Limited proteolysis: DisRUPting proteasomal inhibition.
Current biology : CB Aug, 2014 | Pubmed ID: 25093561
The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B.
Nucleic acids research , 2014 | Pubmed ID: 25183520
MicroRNAs meet calcium: joint venture in ER proteostasis.
Science signaling Nov, 2014 | Pubmed ID: 25372053
Regulation of the DNA damage response by ubiquitin conjugation.
Frontiers in genetics , 2015 | Pubmed ID: 25806049
Challenging muscle homeostasis uncovers novel chaperone interactions in Caenorhabditis elegans.
Frontiers in molecular biosciences , 2014 | Pubmed ID: 25988162
Double-edged alliance: mitochondrial surveillance by the UPS and autophagy.
Current opinion in cell biology Dec, 2015 | Pubmed ID: 26343990
Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.
Nature communications Feb, 2016 | Pubmed ID: 26842564
Ring of Change: CDC48/p97 Drives Protein Dynamics at Chromatin.
Frontiers in genetics , 2016 | Pubmed ID: 27200082
It's all about talking: two-way communication between proteasomal and lysosomal degradation pathways via ubiquitin.
American journal of physiology. Cell physiology 08, 2016 | Pubmed ID: 27225656
E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis.
Nature structural & molecular biology Nov, 2016 | Pubmed ID: 27669035
Stefan Jentsch (1955-2016)-Maestro of the ubiquitin family.
The EMBO journal 01, 2017 | Pubmed ID: 27974363
The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover.
Cell 04, 2017 | Pubmed ID: 28431247
Repair or destruction-an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasis.
FEBS letters 09, 2017 | Pubmed ID: 28699655
Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD).
Journal of cell science Oct, 2017 | Pubmed ID: 28827405
Chaperone-directed ubiquitylation maintains proteostasis at the expense of longevity.
Worm , 2017 | Pubmed ID: 28959501
CHIPped balance of proteostasis and longevity.
Oncotarget Nov, 2017 | Pubmed ID: 29228542
Stressed Out: Mitohormesis Is Crossing Borders.
Trends in endocrinology and metabolism: TEM 08, 2018 | Pubmed ID: 29605660
Ubiquitylation Pathways In Insulin Signaling and Organismal Homeostasis.
BioEssays : news and reviews in molecular, cellular and developmental biology 05, 2018 | Pubmed ID: 29611634
Ub and Down: Ubiquitin Exercise for the Elderly.
Trends in cell biology 07, 2018 | Pubmed ID: 29704981
The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients.
Nature communications 07, 2018 | Pubmed ID: 30038412
ERADicate Tumor Progression with Metformin.
Molecular cell 08, 2018 | Pubmed ID: 30118675
Hepatic ERAD takes control of the organism.
The EMBO journal 11, 2018 | Pubmed ID: 30389670
Western blot analysis of the autophagosomal membrane protein LGG-1/LC3 in Caenorhabditis elegans.
Methods in enzymology , 2019 | Pubmed ID: 30910027
Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signaling.
Nature metabolism 03, 2019 | Pubmed ID: 31535080
The Machado-Joseph disease deubiquitylase ataxin-3 interacts with LC3C/GABARAP and promotes autophagy.
Aging cell 01, 2020 | Pubmed ID: 31625269
Latest advances in aging research and drug discovery.
Aging 11, 2019 | Pubmed ID: 31770722
The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy.
Nature communications 12, 2019 | Pubmed ID: 31827090
Author Correction: The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients.
Nature communications Feb, 2020 | Pubmed ID: 32066719
Regulation of E3 ubiquitin ligases by homotypic and heterotypic assembly.
F1000Research , 2020 | Pubmed ID: 32076548
Mitochondrial Quality Control Governed by Ubiquitin.
Frontiers in cell and developmental biology , 2020 | Pubmed ID: 32391359
The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells.
Communications biology 05, 2020 | Pubmed ID: 32451438
Author Correction: Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signalling.
Nature metabolism Jan, 2020 | Pubmed ID: 32694680
Organismal Protein Homeostasis Mechanisms.
Genetics 08, 2020 | Pubmed ID: 32759342
CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage.
Cell death & disease 09, 2020 | Pubmed ID: 32913203
Ubiquitin-dependent regulation of a conserved DMRT protein controls sexually dimorphic synaptic connectivity and behavior.
eLife 10, 2020 | Pubmed ID: 33021200
Pathogenic Variants in the Myosin Chaperone UNC-45B Cause Progressive Myopathy with Eccentric Cores.
American journal of human genetics 12, 2020 | Pubmed ID: 33217308
The price of longevity.
Aging 11, 2020 | Pubmed ID: 33253121
Build-UPS and break-downs: metabolism impacts on proteostasis and aging.
Cell death and differentiation Feb, 2021 | Pubmed ID: 33398091
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Autophagy Feb, 2021 | Pubmed ID: 33634751
Correction to: Build-UPS and break-downs: metabolism impacts on proteostasis and aging.
Cell death and differentiation May, 2021 | Pubmed ID: 33976390
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