Frederick A. Dick

Three regions of the pRB pocket domain affect its inactivation by human papillomavirus E7 proteins.

pRB contains an E2F1-specific binding domain that allows E2F1-induced apoptosis to be regulated separately from other E2F activities.

The retinoblastoma protein regulates pericentric heterochromatin.

Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit.

Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts?

A functional connection between pRB and transforming growth factor beta in growth inhibition and mammary gland development.

A G1 checkpoint mediated by the retinoblastoma protein that is dispensable in terminal differentiation but essential for senescence.

A cancer derived mutation in the retinoblastoma gene with a distinct defect for LXCXE dependent interactions.

Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive.

An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein.

The biochemical basis of CDK phosphorylation-independent regulation of E2F1 by the retinoblastoma protein.

A context-specific role for retinoblastoma protein-dependent negative growth control in suppressing mammary tumorigenesis.

Sweet DREAMs for Hippo.

DNA Damage Signals through Differentially Modified E2F1 Molecules To Induce Apoptosis.

Chromosome instability and deregulated proliferation: an unavoidable duo.