Megan L. Stanifer
Department of Infectious Diseases,
Molecular Virology,
Department of Infectious Diseases, Molecular Virology
Heidelberg University Hospital
Megan Stanifer is an Assistant Professor at the University of Florida in the Department of Molecular Genetics and Microbiology. She received her bachelors in Chemistry from Boston University and her PhD in Molecular Biology, Cell Biology and Biochemistry from Brown University.
Megan has been interested in understanding virus-host interactions since her PhD where she studied the human polyomavirus JCV. She continued studying viruses through her first post-doctoral training at Harvard Medical School where she investigated the entry and fusion of VSV. During a second post-doc at the University of Heidelberg, Germany she began to focus more on enteric pathogens and how they are infecting primary human intestinal cells. During this second post-doc, she began to establish human mini-gut organoid cultures to have a deeper understanding of how the host combats virus infection.
Type I and Type III Interferons Display Different Dependency on Mitogen-Activated Protein Kinases to Mount an Antiviral State in the Human Gut.
Frontiers in immunology , 2017 | Pubmed ID: 28484457
Genome packaging of reovirus is mediated by the scaffolding property of the microtubule network.
Cellular microbiology 12, 2017 | Pubmed ID: 28672089
Reversible Fusion Proteins as a Tool to Enhance Uptake of Virus-Functionalized LbL Microcarriers.
Biomacromolecules 08, 2018 | Pubmed ID: 29966082
Rubella Virus Strain-Associated Differences in the Induction of Oxidative Stress Are Independent of Their Interferon Activation.
Viruses 10, 2018 | Pubmed ID: 30282907
Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance.
PLoS pathogens 11, 2018 | Pubmed ID: 30485383
Differential Regulation of Type I and Type III Interferon Signaling.
International journal of molecular sciences Mar, 2019 | Pubmed ID: 30901970
Hypoxic Environment Promotes Barrier Formation in Human Intestinal Epithelial Cells through Regulation of MicroRNA 320a Expression.
Molecular and cellular biology 07, 2019 | Pubmed ID: 31061092
Type-Specific Crosstalk Modulates Interferon Signaling in Intestinal Epithelial Cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 10, 2019 | Pubmed ID: 31199715
Teratogenic Rubella Virus Alters the Endodermal Differentiation Capacity of Human Induced Pluripotent Stem Cells.
Cells 08, 2019 | Pubmed ID: 31405163
Asymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cells.
Nature microbiology 01, 2020 | Pubmed ID: 31686029
3D Correlative Cryo-Structured Illumination Fluorescence and Soft X-ray Microscopy Elucidates Reovirus Intracellular Release Pathway.
Cell Jul, 2020 | Pubmed ID: 32610083
Development of Feline Ileum- and Colon-Derived Organoids and Their Potential Use to Support Feline Coronavirus Infection.
Cells 09, 2020 | Pubmed ID: 32932592
Importance of Type I and III Interferons at Respiratory and Intestinal Barrier Surfaces.
Frontiers in immunology , 2020 | Pubmed ID: 33362795
Single-cell analyses reveal SARS-CoV-2 interference with intrinsic immune response in the human gut.
Molecular systems biology 04, 2021 | Pubmed ID: 33904651
Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5.
Nature communications 09, 2021 | Pubmed ID: 34493730
Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 (BSL-3) Conditions
1Department of Infectious Diseases, Molecular Virology, Heidelberg University Hospital,
2Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville,
3Department of Infectious Diseases, Virology, Heidelberg University Hospital,
4Research Group “Cellular Polarity and Viral Infection”, German Cancer Research Center (DKFZ)
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