Joan S. Brugge

Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.

Sensing the environment: a historical perspective on integrin signal transduction.

Direct phosphorylation of focal adhesion kinase by c-Src: evidence using a modified nucleotide pocket kinase and ATP analog.

The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini.

Overview of the Alliance for Cellular Signaling.

Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures.

Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis.

The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor.

Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner.

Src kinase activation by direct interaction with the integrin beta cytoplasmic domain.

Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells.

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro.

A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth.

ErbB2 and TGF-beta: a cooperative role in mammary tumor progression?

Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture.

Vav GEFs are required for beta2 integrin-dependent functions of neutrophils.

Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells.

Use of three-dimensional basement membrane cultures to model oncogene-induced changes in mammary epithelial morphogenesis.

Vav family GEFs link activated Ephs to endocytosis and axon guidance.

Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes.

G1/S cell cycle arrest provides anoikis resistance through Erk-mediated Bim suppression.

Activation of NF-kappaB following detachment delays apoptosis in intestinal epithelial cells.

Modelling glandular epithelial cancers in three-dimensional cultures.

Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells.

Novel role for PDEF in epithelial cell migration and invasion.

Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition.

Functional proteomics approach to investigate the biological activities of cDNAs implicated in breast cancer.

Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis.

An active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligand.

p63 regulates an adhesion programme and cell survival in epithelial cells.

Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon.

SePARating polarity and proliferation in ErbB2 oncogenesis.

BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms.

p63, cell adhesion and survival.

Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis.

Common effector processing mediates cell-specific responses to stimuli.

Tensins: a new switch in cell migration.

Engineering tumors with 3D scaffolds.

A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion.

IL-6 involvement in epithelial cancers.

Circulating colony stimulating factor-1 and breast cancer risk.

Lumen formation during mammary epithelial morphogenesis: insights from in vitro and in vivo models.

[Entosis, a cell death process related to cell cannibalism between tumor cells].

Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1.

The cell biology of cell-in-cell structures.

Identification of genes that regulate epithelial cell migration using an siRNA screening approach.

Fibroblast growth factor receptor 1-transformed mammary epithelial cells are dependent on RSK activity for growth and survival.

YB-1 translational control of epithelial-mesenchyme transition.

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment.

YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway.

Transcriptional regulation of metastatic [Id]entity by KLF17.

A stiff blow from the stroma: collagen crosslinking drives tumor progression.

Tumor self-seeding: bidirectional flow of tumor cells.

Mutant p53 drives invasion by promoting integrin recycling.

MYC regulation of a "poor-prognosis" metastatic cancer cell state.

Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells.

Identifying single-cell molecular programs by stochastic profiling.

Unregulated ARF6 activation in epithelial cysts generates hyperactive signaling endosomes and disrupts morphogenesis.

PTK6 regulates IGF-1-induced anchorage-independent survival.

ErbB2 stabilizes epidermal growth factor receptor (EGFR) expression via Erk and Sprouty2 in extracellular matrix-detached cells.

Profiling Y561-dependent and -independent substrates of CSF-1R in epithelial cells.

Mechanistic biology in the next quarter century.

A non-genetic route to aneuploidy in human cancers.

Uncovering a tumor suppressor for triple-negative breast cancers.

Psidin, a conserved protein that regulates protrusion dynamics and cell migration.

The myosin-II-responsive focal adhesion proteome: a tour de force?

The myosin-II-responsive focal adhesion proteome: a tour de force?

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.

Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation.

Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression.

Ovarian cancer spheroids use myosin-generated force to clear the mesothelium.

Outgrowth of single oncogene-expressing cells from suppressive epithelial environments.