Todd Manini

Blood flow restricted exercise and skeletal muscle health.

Activity energy expenditure and mobility limitation in older adults: differential associations by sex.

Energy expenditure and aging.

Activity energy expenditure and change in body composition in late life.

Effects of exercise on mobility in obese and nonobese older adults.

Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy.

Dynapenia and aging: an update.

Development of physical disability in older adults.

An exploratory analysis of the effects of a weight loss plus exercise program on cellular quality control mechanisms in older overweight women.

Usefulness of preclinical models for assessing the efficacy of late-life interventions for sarcopenia.

Effects of a weight loss plus exercise program on physical function in overweight, older women: a randomized controlled trial.

Commentaries on Viewpoint: Expending our physical activity (measurement) budget wisely.

The impact of behavioral intervention on obesity mediated declines in mobility function: implications for longevity.

Age-related differences in lower extremity tissue compartments and associations with physical function in older adults.

Metabolic cost of daily activities and effect of mobility impairment in older adults.

Obesity and use of compensatory strategies to perform common daily activities in pre-clinically disabled older adults.

Skeletal muscle apoptotic signaling predicts thigh muscle volume and gait speed in community-dwelling older persons: an exploratory study.

Pain-related fear and catastrophizing predict pain intensity and disability independently using an induced muscle injury model.

What is dynapenia?

Mitochondrial DNA sequence variation is associated with free-living activity energy expenditure in the elderly.

Blood flow restriction enhances post-resistance exercise angiogenic gene expression.

The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals.

Angiotensin-converting enzyme inhibitor use by older adults is associated with greater functional responses to exercise.

Growth hormone responses to acute resistance exercise with vascular restriction in young and old men.

Role of self-efficacy (SE) and anxiety among pre-clinically disabled older adults when using compensatory strategies to complete daily tasks.

Relation of pulse pressure to long-distance gait speed in community-dwelling older adults: findings from the LIFE-P study.

Aging and muscle: a neuron's perspective.

Mobility decline in old age: a time to intervene.

Neuromuscular determinants of maximum walking speed in well-functioning older adults.

Functional language networks in sedentary and physically active older adults.

Active muscle regeneration following eccentric contraction-induced injury is similar between healthy young and older adults.

Effect of dietary restriction and exercise on lower extremity tissue compartments in obese, older women: a pilot study.

Longitudinal change in energy expenditure and effects on energy requirements of the elderly.

Change in physical activity after a diabetes diagnosis: opportunity for intervention.

Prestroke factors associated with poststroke mortality and recovery in older women in the Women's Health Initiative.

Promoting physical activity for elders with compromised function: the lifestyle interventions and independence for elders (LIFE) study physical activity intervention.

Modifying effect of obesity on the association between sitting and incident diabetes in post-menopausal women.

Mitochondrial DNA sequence associations with dementia and amyloid-β in elderly African Americans.

Diving below the surface of progressive disability: considering compensatory strategies as evidence of sub-clinical disability.

Snoring, daytime sleepiness, and incident cardiovascular disease in the health, aging, and body composition study.

Effects of aerobic fitness on aging-related changes of interhemispheric inhibition and motor performance.

Obesity and late-age survival without major disease or disability in older women.

Sedentary behavior and mortality in older women: the Women's Health Initiative.

Respiratory impairment and dyspnea and their associations with physical inactivity and mobility in sedentary community-dwelling older persons.

Activity-related energy expenditure in older adults: a call for more research.

Safety and metabolic outcomes of resveratrol supplementation in older adults: results of a twelve-week, placebo-controlled pilot study.

Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial.

Aging, aerobic activity and interhemispheric communication.

Combined reduced forced expiratory volume in 1 second (FEV1) and peripheral artery disease in sedentary elders with functional limitations.

The LIFE Cognition Study: design and baseline characteristics.

Interventions to reduce sedentary behavior.

Physical activity behavior, barriers to activity, and opinions about a smartphone-based physical activity intervention among rural residents.

A physical activity intervention to treat the frailty syndrome in older persons-results from the LIFE-P study.

Patterns of circulating inflammatory biomarkers in older persons with varying levels of physical performance: a partial least squares-discriminant analysis approach.

Light Intensity physical activity and sedentary behavior in relation to body mass index and grip strength in older adults: cross-sectional findings from the Lifestyle Interventions and Independence for Elders (LIFE) study.

The MAT-sf: identifying risk for major mobility disability.

Association of objectively measured physical activity with cardiovascular risk in mobility-limited older adults.

Using physical activity to gain the most public health bang for the buck.

Associations Between Ankle-Brachial Index and Cognitive Function: Results From the Lifestyle Interventions and Independence for Elders Trial.

Kaatsu training to enhance physical function of older adults with knee osteoarthritis: Design of a randomized controlled trial.

Sedentary time is associated with the metabolic syndrome in older adults with mobility limitations--The LIFE Study.

Increased inflammation but similar physical composition and function in older-aged, HIV-1 infected subjects.

Depressive symptom severity is associated with increased cortical thickness in older adults.

Mitochondrial DNA Heteroplasmy Associations With Neurosensory and Mobility Function in Elderly Adults.

Successful aging: Advancing the science of physical independence in older adults.

Analysis and Interpretation of Accelerometry Data in Older Adults: The LIFE Study.

Cross-sectional and longitudinal risk of physical impairment in a cohort of postmenopausal women who experience physical and verbal abuse.

An observational study identifying obese subgroups among older adults at increased risk of mobility disability: do perceptions of the neighborhood environment matter?

Age Differences in Prefrontal Surface Area and Thickness in Middle Aged to Older Adults.

Effectiveness of blood flow restricted exercise compared with standard exercise in patients with recurrent low back pain: study protocol for a randomized controlled trial.

Can KAATSU Exercise Cause Rhabdomyolysis?

Cost-effectiveness of the LIFE Physical Activity Intervention for Older Adults at Increased Risk for Mobility Disability.

Long-Term Cigarette Smoking Trajectories Among HIV-Seropositive and Seronegative MSM in the Multicenter AIDS Cohort Study.

In-Hospital Mobility Variations Across Primary Diagnoses Among Older Adults.

Genetic Moderators of the Impact of Physical Activity on Depressive Symptoms.

Socioeconomic differences in the benefits of structured physical activity compared with health education on the prevention of major mobility disability in older adults: the LIFE study.

Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical Trial.

Physical impairment and body weight history in postmenopausal women: the Women's Health Initiative.

Metabolic Rate and Perceived Exertion of Walking in Older Adults With Idiopathic Chronic Fatigue.

Evaluating Walking Intensity with Hip-Worn Accelerometers in Elders.

Idiopathic chronic fatigue in older adults is linked to impaired mitochondrial content and biogenesis signaling in skeletal muscle.

Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study.

Letter to the editor: results from a Web-based survey to identify dynapenia screening tools and risk factors.

Anticholinergic Drug Use and Risk to Cognitive Performance in Older Adults with Questionable Cognitive Impairment: A Cross-Sectional Analysis.

Actigraphy features for predicting mobility disability in older adults.

Impact of chemotherapy on medium-term physical function and activity of older breast cancer survivors, and associated biomarkers.

Using symbolic aggregate approximation (SAX) to visualize activity transitions among older adults.

Systemic inflammation, body composition, and physical performance in old community-dwellers.

Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study.

Effects of blood-flow restriction on biomarkers of myogenesis in response to resistance exercise.

Effect of Physical Activity on Self-Reported Disability in Older Adults: Results from the LIFE Study.

Effect of Physical Activity versus Health Education on Physical Function, Grip Strength and Mobility.

The Need for Standardized Assessment of Muscle Quality in Skeletal Muscle Function Deficit and Other Aging-Related Muscle Dysfunctions: A Symposium Report.

Association of Accelerometer-Measured Physical Activity With Leukocyte Telomere Length Among Older Women.

The effect of intervening hospitalizations on the benefit of structured physical activity in promoting independent mobility among community-living older persons: secondary analysis of a randomized controlled trial.

Osteoporosis in the Women's Health Initiative: Another Treatment Gap?

Social Participation Modifies the Effect of a Structured Physical Activity Program on Major Mobility Disability Among Older Adults: Results From the LIFE Study.

Change in Physical Activity and Sitting Time After Myocardial Infarction and Mortality Among Postmenopausal Women in the Women's Health Initiative-Observational Study.

Transition Icons for Time-Series Visualization and Exploratory Analysis.

Leisure-time physical activity and leukocyte telomere length among older women.

Prognostic Value of Braden Activity Subscale for Mobility Status in Hospitalized Older Adults.

Exercise's effect on mobility disability in older adults with and without obesity: The LIFE study randomized clinical trial.

Association between age-related reductions in testosterone and risk of prostate cancer-An analysis of patients' data with prostatic diseases.

Association Between Structured Physical Activity and Sedentary Time in Older Adults.

ENabling Reduction of Low-grade Inflammation in SEniors Pilot Study: Concept, Rationale, and Design.

Effects of Popular Diets without Specific Calorie Targets on Weight Loss Outcomes: Systematic Review of Findings from Clinical Trials.

Device-Measured Physical Activity As a Predictor of Disability in Mobility-Limited Older Adults.

Dose of physical activity, physical functioning and disability risk in mobility-limited older adults: Results from the LIFE study randomized trial.

Wearable technology to reduce sedentary behavior and CVD risk in older adults: design of a randomized controlled trial.

A Comparison of Self-report Indices of Major Mobility Disability to Failure on the 400-m Walk Test: The LIFE Study.

Evaluating Accelerometry Thresholds for Detecting Changes in Levels of Moderate Physical Activity and Resulting Major Mobility Disability.

Blood flow restricted resistance training in older adults at risk of mobility limitations.

Surveying predictors of late-life longitudinal change in daily activity energy expenditure.

Effects of a Long-Term Physical Activity Program on Activity Patterns in Older Adults.

The Influence of Physical Activity and Sedentary Behavior on Living to Age 85 Years Without Disease and Disability in Older Women.

Association of Accelerometry-Measured Physical Activity and Cardiovascular Events in Mobility-Limited Older Adults: The LIFE (Lifestyle Interventions and Independence for Elders) Study.

Effect of Physical Activity on Frailty: Secondary Analysis of a Randomized Controlled Trial.

Maintenance of Physical Function 1 Year After Exercise Intervention in At-Risk Older Adults: Follow-up From the LIFE Study.

Effects of 90 Days of Resveratrol Supplementation on Cognitive Function in Elders: A Pilot Study.

Gait Speed and Mobility Disability: Revisiting Meaningful Levels in Diverse Clinical Populations.

Dopamine-Related Genotypes and Physical Activity Change During an Intervention: The Lifestyle Interventions and Independence for Elders Study.

Associations between ACE-Inhibitors, Angiotensin Receptor Blockers, and Lean Body Mass in Community Dwelling Older Women.

Mitochondrial DNA m.13514G>A heteroplasmy is associated with depressive symptoms in the elderly.

Translating the Lifestyle Interventions and Independence for Elders Clinical Trial to Older Adults in a Real-World Community-Based Setting.

Mitochondrial DNA m.3243A > G heteroplasmy affects multiple aging phenotypes and risk of mortality.

The Enabling Reduction of Low-Grade Inflammation in Seniors (ENRGISE) Pilot Study: Screening Methods and Recruitment Results.

Diet and Activity Assessments and Interventions Using Technology in Older Adults.

Self-Reported Physical Function As a Predictor of Hospitalization in the Lifestyle Interventions and Independence for Elders Study.

Meta-analysis identifies mitochondrial DNA sequence variants associated with walking speed.

Effect of 24-month physical activity on cognitive frailty and the role of inflammation: the LIFE randomized clinical trial.

Mitochondrial DNA Sequence Variants Associated With Blood Pressure Among 2 Cohorts of Older Adults.

Movement-evoked pain: transforming the way we understand and measure pain.

Activity and Circadian Rhythm of Sepsis Patients in the Intensive Care Unit.

A smartwatch-based framework for real-time and online assessment and mobility monitoring.

Effect of Hospitalizations on Physical Activity Patterns in Mobility-Limited Older Adults.

Community-Based Activity and Sedentary Patterns Are Associated With Cognitive Performance in Mobility-Limited Older Adults.

Mitochondrial DNA variants and pulmonary function in older persons.

Wrist accelerometer shape feature derivation methods for assessing activities of daily living.

Effect of Losartan and Fish Oil on Plasma IL-6 and Mobility in Older Persons. The ENRGISE Pilot Randomized Clinical Trial.

Comment on: "Pitfalls in the measurement of muscle mass: a need for a reference standard" by Buckinx et al.

Accuracy of Samsung Gear S Smartwatch for Activity Recognition: Validation Study.

A Case for Promoting Movement Medicine: Preventing Disability in the LIFE Randomized Controlled Trial.

Blood-Flow Restriction Resistance Exercise for Older Adults with Knee Osteoarthritis: A Pilot Randomized Clinical Trial.

The Effects of Electrical Stimulation Pulse Duration on Lingual Palatal Pressure Measures During Swallowing in Healthy Older Adults.

Establishing the Link Between Lean Mass and Grip Strength Cut Points With Mobility Disability and Other Health Outcomes: Proceedings of the Sarcopenia Definition and Outcomes Consortium Conference.

Perception of Older Adults Toward Smartwatch Technology for Assessing Pain and Related Patient-Reported Outcomes: Pilot Study.

Blood Flow-restricted Exercise Does Not Induce a Cross-Transfer of Effect: A Randomized Controlled Trial.

Comparative Effects of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on Response to a Physical Activity Intervention in Older Adults: Results From the Lifestyle Interventions and Independence for Elders Study.

A comparison of accelerometry analysis methods for physical activity in older adult women and associations with health outcomes over time.

Transcutaneous Electrical Stimulation on the Submental Area: The Relations of Biopsychological Factors with Maximum Amplitude Tolerance and Perceived Discomfort Level.

Effect of Gastric Acid Suppressants on Response to a Physical Activity Intervention and Major Mobility Disability in Older Adults: Results from the Lifestyle Interventions for Elders (LIFE) Study.

The Effects of Time Restricted Feeding on Overweight, Older Adults: A Pilot Study.

Voluntary vs Electrically Stimulated Activation in Age-Related Muscle Weakness.

Evaluation of the Potential Acetylcholinesterase Inhibitor-Induced Rhinorrhea Prescribing Cascade.

Association of Fish Oil and Physical Activity on Mobility Disability in Older Adults.

Wearable Technology To Reduce Sedentary Behavior And CVD Risk In Older Adults: A Pilot Randomized Clinical Trial.

Healthcare Utilization and Physical Functioning in Older Adults in the United States.

Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal Muscle.

Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability.

Magnitude of and Characteristics Associated With the Treatment of Calcium Channel Blocker-Induced Lower-Extremity Edema With Loop Diuretics.

Multimodal Imaging of Brain Activity to Investigate Walking and Mobility Decline in Older Adults (Mind in Motion Study): Hypothesis, Theory, and Methods.

Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability.

Secondary care provider attitudes towards patient generated health data from smartwatches.

Sarcopenia Definition: The Position Statements of the Sarcopenia Definition and Outcomes Consortium.

Role of Wearable Accelerometer Devices in Delirium Studies: A Systematic Review.

Corrigendum: Multimodal Imaging of Brain Activity to Investigate Walking and Mobility Decline in Older Adults (Mind in Motion Study): Hypothesis, Theory, and Methods.

Application of SDOC Cut Points for Low Muscle Strength for Recovery of Walking Speed After Hip Fracture.

Three-Year, Postintervention, Follow-up Comparison of Health Care Resource Utilization and Costs in the Lifestyle Interventions and Independence for Elders (LIFE) Study.

Application of Selected Muscle Strength and Body Mass Cut Points for the Diagnosis of Sarcopenia in Men and Women With or at Risk for HIV Infection.

The relationship between interleukin-6 levels and physical performance in mobility-limited older adults with chronic low-grade inflammation: The ENRGISE Pilot study.

Reduced Neural Excitability and Activation Contribute to Clinically Meaningful Weakness in Older Adults.

Putative Cut-Points in Sarcopenia Components and Incident Adverse Health Outcomes: An SDOC Analysis.

Sarcopenia Definition & Outcomes Consortium Defined Low Grip Strength in Two Cross-Sectional, Population-Based Cohorts.

Identification of Sarcopenia Components That Discriminate Slow Walking Speed: A Pooled Data Analysis.

Application of Cut-Points for Low Muscle Strength and Lean Mass in Mobility-Limited Older Adults.

Trajectories of Short Physical Performance Battery Are Strongly Associated with Future Major Mobility Disability: Results from the LIFE Study.

Relative contribution of muscle strength, lean mass, and lower extremity motor function in explaining between-person variance in mobility in older adults.

Impact of Anticholinergic Medication Burden on Mobility and Falls in the Lifestyle Interventions for Elders (LIFE) Study.

Effect of a Multifactorial Fall Injury Prevention Intervention on Patient Well-Being: The STRIDE Study.

A Simulated Graphical Interface for Integrating Patient-Generated Health Data From Smartwatches With Electronic Health Records: Usability Study.

Innovations in Geroscience to enhance mobility in older adults.

Survey-reported medication changes among older adults during the SARS-CoV-2 (COVID-19) pandemic.

Association between a Deficit Accumulation Frailty Index and Mobility Outcomes in Older Adults: Secondary Analysis of the Lifestyle Interventions and Independence for Elders (LIFE) Study.

Altered Expression of Mitoferrin and Frataxin, Larger Labile Iron Pool and Greater Mitochondrial DNA Damage in the Skeletal Muscle of Older Adults.

The Temporal Relationship Between Ecological Pain and Life-Space Mobility in Older Adults With Knee Osteoarthritis: A Smartwatch-Based Demonstration Study.

Ratings of Perceived Exertion During Walking: Predicting Major Mobility Disability and Effect of Structured Physical Activity in Mobility-Limited Older Adults.

Evaluation of a Strength-Training Program on Clinical Outcomes in Older Adults.

Effect of Low-Intensity vs High-Intensity Home-Based Walking Exercise on Walk Distance in Patients With Peripheral Artery Disease: The LITE Randomized Clinical Trial.

Elevated IL-6 and CRP Levels Are Associated With Incident Self-Reported Major Mobility Disability: A Pooled Analysis of Older Adults With Slow Gait Speed.

Sustained physical activity in peripheral artery disease: Associations with disease severity, functional performance, health-related quality of life, and subsequent serious adverse events in the LITE randomized clinical trial.

Deep CHORES: Estimating Hallmark Measures of Physical Activity Using Deep Learning.

The Effect of Sensor Placement and Number on Physical Activity Recognition and Energy Expenditure Estimation in Older Adults: Validation Study.

Study Protocol Modeling Evoked Pain in Older African Americans With Knee Osteoarthritis.

Age Differences in Estimating Physical Activity by Wrist Accelerometry Using Machine Learning.

Differences in Health-Related Quality of Life Among Adults with a Potential Dihydropyridine Calcium Channel Blocker-Loop Diuretic Prescribing Cascade.

What Cut-Point in Gait Speed Best Discriminates Community-Dwelling Older Adults With Mobility Complaints From Those Without? A Pooled Analysis From the Sarcopenia Definitions and Outcomes Consortium.

Functional connectivity of key resting state networks and objectively measured physical activity in older adults with joint pain: A pilot study.

Satisfaction, Usability, and Compliance With the Use of Smartwatches for Ecological Momentary Assessment of Knee Osteoarthritis Symptoms in Older Adults: Usability Study.

Evaluation of the key prescription sequence symmetry analysis assumption using the calcium channel blocker: Loop diuretic prescribing cascade.

Are Machine Learning Models on Wrist Accelerometry Robust against Differences in Physical Performance among Older Adults?

Kinematic analysis of speed transitions within walking in younger and older adults.

Worsening sleep predicts lower life space mobility during the onset of the COVID-19 pandemic.

Frailty and risk of mortality in older cancer survivors and adults without a cancer history: Evidence from the National Health and Nutrition Examination Survey, 1999-2014.

Effects of Walking Exercise at a Pace With Versus Without Ischemic Leg Symptoms on Functional Performance Measures in People With Lower Extremity Peripheral Artery Disease: The LITE Randomized Clinical Trial.

Effect of change of interleukin-6 over time on gait speed response: Results from the lifestyle interventions and independence for elders study.

Uneven terrain treadmill walking in younger and older adults.

Feasibility of a Smartwatch Platform to Assess Ecological Mobility: Real-Time Online Assessment and Mobility Monitor.

Comparing D3-Creatine Dilution and Dual-Energy X-ray Absorptiometry Muscle Mass Responses to Strength Training in Low-Functioning Older Adults.

Associations of Total Body Fat Mass and Skeletal Muscle Index with All-Cause and Cancer-Specific Mortality in Cancer Survivors.

Effect of Physical Activity Intervention on Gait Speed by Frailty Condition: A Randomized Clinical Trial.

Muscle Quality in Older Adults: A Scoping Review.

Uneven terrain versus dual-task walking: differential challenges imposed on walking behavior in older adults are predicted by cognitive and sensorimotor function.

Comparisons Between GPS-based and Self-reported Life-space Mobility in Older Adults.

Media Consumption and COVID-19-Related Precautionary Behaviors During the Early Pandemic: Survey Study of Older Adults.

Comparison of EEG Source Localization Using Simplified and Anatomically Accurate Head Models in Younger and Older Adults.

Defining and Measuring Preclinical Mobility Limitation: An Expert Consensus Exercise Informed by a Scoping Review.

Electrical Brain Activity during Human Walking with Parametric Variations in Terrain Unevenness and Walking Speed.

Hospitalizations during home-based walking exercise interventions in peripheral artery disease: Results from two randomized clinical trials.

Independent and joint associations of cardiorespiratory fitness and lower-limb muscle strength with cardiometabolic risk in older adults.