Christoph Wittmann

In vivo analysis of intracellular amino acid labelings by GC/MS.

Derivatization of small biomolecules for optimized matrix-assisted laser desorption/ionization mass spectrometry.

Correcting mass isotopomer distributions for naturally occurring isotopes.

Metabolic physiology of aroma-producing Kluyveromyces marxianus.

Genealogy profiling through strain improvement by using metabolic network analysis: metabolic flux genealogy of several generations of lysine-producing corynebacteria.

Integrated optical sensing of dissolved oxygen in microtiter plates: a novel tool for microbial cultivation.

Free intracellular amino acid pools during autonomous oscillations in Saccharomyces cerevisiae.

Characterization and application of an optical sensor for quantification of dissolved O2 in shake-flasks.

Dynamic calibration and dissolved gas analysis using membrane inlet mass spectrometry for the quantification of cell respiration.

Software tool for automated processing of 13C labeling data from mass spectrometric spectra.

Comparative metabolic flux analysis of lysine-producing Corynebacterium glutamicum cultured on glucose or fructose.

In-depth profiling of lysine-producing Corynebacterium glutamicum by combined analysis of the transcriptome, metabolome, and fluxome.

Minibioreactors.

Impact of the cold shock phenomenon on quantification of intracellular metabolites in bacteria.

Metabolic network analysis of lysine producing Corynebacterium glutamicum at a miniaturized scale.

Metabolic network simulation using logical loop algorithm and Jacobian matrix.

Metabolic fluxes in Corynebacterium glutamicum during lysine production with sucrose as carbon source.

Dynamics of intracellular metabolites of glycolysis and TCA cycle during cell-cycle-related oscillation in Saccharomyces cerevisiae.

In vivo quantification of intracellular amino acids and intermediates of the methionine pathway in Corynebacterium glutamicum.

Theoretical aspects of 13C metabolic flux analysis with sole quantification of carbon dioxide labeling.

Characterization of the metabolic shift between oxidative and fermentative growth in Saccharomyces cerevisiae by comparative 13C flux analysis.

Application of cation-exchange membranes for characterisation and imaging ammonia-oxidising bacteria in soils.

Amplified expression of fructose 1,6-bisphosphatase in Corynebacterium glutamicum increases in vivo flux through the pentose phosphate pathway and lysine production on different carbon sources.

Quantification of S-adenosyl methionine in microbial cell extracts.

Accumulation of homolanthionine and activation of a novel pathway for isoleucine biosynthesis in Corynebacterium glutamicum McbR deletion strains.

Metabolic pathway analysis for rational design of L-methionine production by Escherichia coli and Corynebacterium glutamicum.

Respirometric 13C flux analysis--Part II: in vivo flux estimation of lysine-producing Corynebacterium glutamicum.

Respirometric 13C flux analysis, Part I: design, construction and validation of a novel multiple reactor system using on-line membrane inlet mass spectrometry.

Comparative study on central metabolic fluxes of Bacillus megaterium strains in continuous culture using 13C labelled substrates.

Transcriptional and metabolic responses of Bacillus subtilis to the availability of organic acids: transcription regulation is important but not sufficient to account for metabolic adaptation.

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for metabolic flux analyses using isotope-labeled ethanol.

Physiology of the yeast Kluyveromyces marxianus during batch and chemostat cultures with glucose as the sole carbon source.

Fluxome analysis using GC-MS.

Sampling for metabolome analysis of microorganisms.

Metabolic flux engineering of L-lysine production in Corynebacterium glutamicum--over expression and modification of G6P dehydrogenase.

Response of the central metabolism of Escherichia coli to modified expression of the gene encoding the glucose-6-phosphate dehydrogenase.

Response of fluxome and metabolome to temperature-induced recombinant protein synthesis in Escherichia coli.

Effect of different carbon sources on central metabolic fluxes and the recombinant production of a hydrolase from Thermobifida fusca in Bacillus megaterium.

Metabolic flux screening of Saccharomyces cerevisiae single knockout strains on glucose and galactose supports elucidation of gene function.

Complete genome sequence of the myxobacterium Sorangium cellulosum.

Metabolic responses to pyruvate kinase deletion in lysine producing Corynebacterium glutamicum.

The yeast Kluyveromyces marxianus and its biotechnological potential.

Analysis of 13C labeling enrichment in microbial culture applying metabolic tracer experiments using gas chromatography-combustion-isotope ratio mass spectrometry.

Appropriate sampling for intracellular amino acid analysis in five phylogenetically different yeasts.

Physiological response of Corynebacterium glutamicum to oxidative stress induced by deletion of the transcriptional repressor McbR.

Metabolite profiling studies in Saccharomyces cerevisiae: an assisting tool to prioritize host targets for antiviral drug screening.

Investigation of the central carbon metabolism of Sorangium cellulosum: metabolic network reconstruction and quantification of pathway fluxes.

OpenFLUX: efficient modelling software for 13C-based metabolic flux analysis.

Metabolic fluxes in the central carbon metabolism of Dinoroseobacter shibae and Phaeobacter gallaeciensis, two members of the marine Roseobacter clade.

Metabolic engineering of the tricarboxylic acid cycle for improved lysine production by Corynebacterium glutamicum.

Morphology engineering of Aspergillus niger for improved enzyme production.

Flux Design: In silico design of cell factories based on correlation of pathway fluxes to desired properties.

Analysis and Engineering of Metabolic Pathway Fluxes in Corynebacterium glutamicum.

Systems-wide metabolic pathway engineering in Corynebacterium glutamicum for bio-based production of diaminopentane.

Optimized bioprocess for production of fructofuranosidase by recombinant Aspergillus niger.

Identification and elimination of the competing N-acetyldiaminopentane pathway for improved production of diaminopentane by Corynebacterium glutamicum.

Towards methionine overproduction in Corynebacterium glutamicum--methanethiol and dimethyldisulfide as reduced sulfur sources.

Metabolic fluxes and beyond-systems biology understanding and engineering of microbial metabolism.

From zero to hero--design-based systems metabolic engineering of Corynebacterium glutamicum for L-lysine production.

Metabolic engineering of Corynebacterium glutamicum for production of 1,5-diaminopentane from hemicellulose.

Filamentous fungi in good shape: microparticles for tailor-made fungal morphology and enhanced enzyme production.

Bio-based production of the platform chemical 1,5-diaminopentane.

Metabolic engineering of cellular transport for overproduction of the platform chemical 1,5-diaminopentane in Corynebacterium glutamicum.

Improved enzyme production by bio-pellets of Aspergillus niger: targeted morphology engineering using titanate microparticles.

Systems biology of recombinant protein production using Bacillus megaterium.

Integration of in vivo and in silico metabolic fluxes for improvement of recombinant protein production.

Bio-based production of chemicals, materials and fuels -Corynebacterium glutamicum as versatile cell factory.

Microbial production of the drugs violacein and deoxyviolacein: analytical development and strain comparison.

Systems and synthetic metabolic engineering for amino acid production - the heartbeat of industrial strain development.

Debottlenecking recombinant protein production in Bacillus megaterium under large scale conditions - targeted precursor feeding designed from metabolomics.

Industrial biotechnology of Pseudomonas putida and related species.