Yujuan Xiao

Jing Xiao is an Associate Research Fellow at the Research center for pharmacology and toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. She received her undergraduate with honors degree from Harbin Medical College, and a Ph.D. from the Tsinghua University, China.

During Dr. Xiao’s Ph.D. training at Tsinghua University (2007 to 2010), she developed a keen focus on research that encompasses regulation of adipocyte differentiation and obesity. By the in vitro and in vivo adipogenesis models, she found an interferon-inducible p204 protein can also play an important role in adipocyte differentiation. As a post-doctoral fellow (2010 to 2012) at research center for pharmacology and toxicology, IMPLAD, she studied the interaction between exogenous estrogens (such as phytoestrogens), cardiovascular diseases, and molecular networks. She then worked as an associate research fellow at IMPLAD, Peking Union Medical College & Chinese Academy of Medical Sciences. As a visiting scholar (2016 to 2017) at Saha Cardiovascular Research Center, University of Kentucky, she studied the pathological mechanisms of atherosclerosis and platelet aggregation.

Dr. Xiao’s research is supported by the National Natural Science Foundation of China, and the Chinese Postdoctoral Science Foundation. Currently her work is mainly focused on cardioprotective effects of adipocytokines on heart dysfunction and atherosclerosis. And her group is trying to find the missing link between obesity and cardiovascular disease. On the other hand, she also carry out researches involved in cardioprotective properties of main active constituents of some Chinese Herbal Medicine and the underlying cellular/molecular mechanisms of these compounds.

Publications

1. Jing Xiao, Ting Zhu, Yue-zhang Yin, Bing Sun. Notoginsenoside R1, a unique constituent of Panax notoginseng, blinds proinflammatory monocytes to protect against cardiac hypertrophy in ApoE(-/-) mice. Eur J Pharmacol. 2018, 833: 441-450.

2. Bing Sun, Jing Xiao, Xiao-Bo Sun, Ying Wu. Notoginsenoside R1 attenuates cardiac dysfunction in endotoxemic mice: an insight into estrogen receptor activation and PI3K/Akt signaling. British Journal of Pharmacology. 2013, 168(7):1758-70. PMID:23170834

3. Jing Xiao, Bing Sun, Ming Li, Ying Wu, Xiao-Bo Sun. A novel adipocytokine visfatin protects against H2O2 -induced myocardial apoptosis: A missing link between obesity and cardiovascular disease. Journal of Cellular Physiology. 2013, 228(3): 495-501. [co-first author] PMID:23065734

4. Bing Sun, Gui-Bo Sun, Jing Xiao, Rong-Chang Chen, Xin Wang, Ying Wu, Li Cao, Zhi-Hong Yang, Xiao-Bo Sun. Isorhamnetin Inhibits H2O2-Induced Activation of the Intrinsic Apoptotic Pathway in H9c2 Cardiomyocytes Through Scavenging Reactive Oxygen Species and ERK Inactivation. Journal of Cellular Biochemistry. 2012, 113(2): 473-485. PMID:21948481

5. Jing Xiao, Gui-Bo Sun, Bing Sun, Ying Wu, Ling He, Xin Wang, Rong-Chang Chen, Li Cao, Xiao-Yu Ren, Xiao-Bo Sun. Kaempferol protects against doxorubicin-induced cardiotoxicity in vivo and in vitro. Toxicology. 2012, 292 (1): 53-62. PMID:22155320

6. Jing Xiao, Bing Sun, Guo-ping Cai. Transient expression of interferon-inducible p204 in the early stage is required for adipogenesis in 3T3-L1 cells. Endocrinology. 2010, 151(7): 3141-53. PMID:20444940

7. Jing Xiao, Nai-li Wang, Bing Sun, Guo-ping Cai. Estrogen receptor mediates the effects of pseudoprotodiocsin on adipogenesis in 3T3-L1 cells. American Journal of Physiology. Cell Physiology. 2010, 299(1): C128-38. PMID:20427709

8. Ping Xie, Xu Zeng, Jing Xiao, Bing Sun, Dan Yang. Transgenic CGI-58 expression in macrophages alleviates the atherosclerotic lesion development in ApoE knockout mice, Biochim Biophys Acta, 2014, 1841(12): 1683-1690.

9. Peng Yue, Yong Zhang, Zhi-Min Du, Jing Xiao, Zheng-Wei Pan, Ning Wang, Hai-Yan Yu, Wen-Cai Ma, Hong Qin, Wen-Hui Wang, Dao-Hong Lin, Bao-Feng Yang. Ischemia impairs the association between connexin 43 and M3 subtype of acetylcholine muscarinic receptor (M3-mAChR) in ventricular myocytes. Cell Physiol Biochem. 2006, 17(3-4):129-136.

Patents

Bing Sun, Jing Xiao. Application of dioscin compound. (CN107375312)