Klaus K. Witte

Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds

Research Area

Medicine

Biography

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JoVE Journal Publications

Article Total : 1	Year
Publication title	2024

Other Publications

Article	Year
Implantable cardioverter-defibrillator therapy in adult patients with tetralogy of Fallot. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology\| PubMed ID: 18442962	2008
Carvedilol in the treatment of elderly patients with chronic heart failure. Clinical interventions in aging\| PubMed ID: 18488879	2008
Chronotropic incompetence does not contribute to submaximal exercise limitation in patients with chronic heart failure. International journal of cardiology\| PubMed ID: 18571253	2009
GPs have pivotal role in managing CHF. The Practitioner\| PubMed ID: 18669368	2008
Cardiac resynchronisation therapy for chronic heart failure and conduction delay. BMJ (Clinical research ed.)\| PubMed ID: 19401320	2009
Marine polyunsaturated fatty acids in heart failure. Are the theoretical benefits matched by the clinical data? Polskie Archiwum Medycyny Wewnetrznej\| PubMed ID: 19514646	2009
Changing characteristics and mode of death associated with chronic heart failure caused by left ventricular systolic dysfunction: a study across therapeutic eras. Circulation. Heart failure\| PubMed ID: 21562056	2011
The intramuscular contribution to the slow oxygen uptake kinetics during exercise in chronic heart failure is related to the severity of the condition. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 22033530	2012
Isolated left ventricular apical hypoplasia evaluated by cardiovascular magnetic resonance and gadolinium enhancement techniques. Journal of the American College of Cardiology\| PubMed ID: 22093515	2011
A novel cardiopulmonary exercise test protocol and criterion to determine maximal oxygen uptake in chronic heart failure. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 22653993	2012
Thromboprophylaxis in heart failure patients with sinus rhythm: aspirin and warfarin lead to similar cardiovascular outcomes. Evidence-based medicine\| PubMed ID: 22918068	2013
Diabetes mellitus is associated with adverse prognosis in chronic heart failure of ischaemic and non-ischaemic aetiology. Diabetes & vascular disease research\| PubMed ID: 23349368	2013
Cardiac resynchronization therapy in pacemaker-dependent patients with left ventricular dysfunction. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology\| PubMed ID: 23736807	2013
Septal pacing: still no clarity? Pacing and clinical electrophysiology : PACE\| PubMed ID: 24325616	2014
Pacing-associated left ventricular dysfunction? Think reprogramming first! Heart (British Cardiac Society)\| PubMed ID: 24430095	2014
Response to (resynchronization) therapy in chronic heart failure: time for a different approach. European journal of heart failure\| PubMed ID: 24464864	2014
Calcium, phosphate and calcium phosphate product are markers of outcome in patients with chronic heart failure. Journal of nephrology\| PubMed ID: 24615401	2015
Micronutrients for chronic heart failure: end of the road or path to enlightenment? JACC. Heart failure\| PubMed ID: 24952701	2014
Patients with long-term permanent pacemakers have a high prevalence of left ventricular dysfunction. Journal of cardiovascular medicine (Hagerstown, Md.)\| PubMed ID: 24979115	2015
Non-invasive vagus nerve stimulation in healthy humans reduces sympathetic nerve activity. Brain stimulation\| PubMed ID: 25164906	2014
An evaluation of 20 year survival in patients with diabetes mellitus and acute myocardial infarction. International journal of cardiology\| PubMed ID: 26512829	2016
Ambulatory heart rate range predicts mode-specific mortality and hospitalisation in chronic heart failure. Heart (British Cardiac Society)\| PubMed ID: 26674986	2016
Cost-effectiveness of an insertable cardiac monitor to detect atrial fibrillation in patients with cryptogenic stroke. International journal of stroke : official journal of the International Stroke Society\| PubMed ID: 26763916	2016
Performance of 2014 NICE defibrillator implantation guidelines in heart failure risk stratification. Heart (British Cardiac Society)\| PubMed ID: 26857212	2016
Effects of Vitamin D on Cardiac Function in Patients With Chronic HF: The VINDICATE Study. Journal of the American College of Cardiology\| PubMed ID: 27058906	2016
Chronotropic Incompetence Does Not Limit Exercise Capacity in Chronic Heart Failure. Journal of the American College of Cardiology\| PubMed ID: 27102504	2016
Diabetes mellitus is associated with adverse structural and functional cardiac remodelling in chronic heart failure with reduced ejection fraction. Diabetes & vascular disease research\| PubMed ID: 27334485	2016
Submaximal fitness and mortality risk reduction in coronary heart disease: a retrospective cohort study of community-based exercise rehabilitation. BMJ open\| PubMed ID: 27363816	2016
Exercise training: The under developed elixir vitae of chronic disease? Diabetes & vascular disease research\| PubMed ID: 28127996	2017
Remote management of heart failure using implantable electronic devices. European heart journal\| PubMed ID: 28575235	2017
Diabetes Mellitus, Microalbuminuria, and Subclinical Cardiac Disease: Identification and Monitoring of Individuals at Risk of Heart Failure. Journal of the American Heart Association\| PubMed ID: 28716801	2017
Mortality Reduction Associated With β-Adrenoceptor Inhibition in Chronic Heart Failure Is Greater in Patients With Diabetes. Diabetes care\| PubMed ID: 28982651	2018
Quantitative deformation analysis differentiates ischaemic and non-ischaemic cardiomyopathy: sub-group analysis of the VINDICATE trial. European heart journal. Cardiovascular Imaging\| PubMed ID: 29029139	2018
Rate-Response Programming Tailored to the Force-Frequency Relationship Improves Exercise Tolerance in Chronic Heart Failure. JACC. Heart failure\| PubMed ID: 29226818	2018
Devices in heart failure; diagnosis, detection and disease modification. British medical bulletin\| PubMed ID: 29342243	2018
Socioeconomic deprivation and mode-specific outcomes in patients with chronic heart failure. Heart (British Cardiac Society)\| PubMed ID: 29386325	2018
Cardiovascular magnetic resonance measures of aortic stiffness in asymptomatic patients with type 2 diabetes: association with glycaemic control and clinical outcomes. Cardiovascular diabetology\| PubMed ID: 29506523	2018
Reliability and Physiological Interpretation of Pulmonary Gas Exchange by "Circulatory Equivalents" in Chronic Heart Failure. Journal of the American Heart Association\| PubMed ID: 29588313	2018
Therapeutic options for functional mitral regurgitation in chronic heart failure. Expert review of medical devices\| PubMed ID: 29724138	2018
Upgrades from a previous device compared to de novo cardiac resynchronization therapy in the European Society of Cardiology CRT Survey II. European journal of heart failure\| PubMed ID: 29806208	2018
Commentaries on Viewpoint: V̇o is an acceptable estimate of cardiorespiratory fitness but not V̇o. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 30043694	2018
Vitamin D deficiency is an independent predictor of mortality in patients with chronic heart failure. European journal of nutrition\| PubMed ID: 30121806	2019
Prevalence and Predictors of Sepsis Death in Patients With Chronic Heart Failure and Reduced Left Ventricular Ejection Fraction. Journal of the American Heart Association\| PubMed ID: 30371261	2018
Ischemic Heart Disease Modifies the Association of Atrial Fibrillation With Mortality in Heart Failure With Reduced Ejection Fraction. Journal of the American Heart Association\| PubMed ID: 30371286	2018
Prospective evaluation and long-term follow-up of patients referred to secondary care based upon natriuretic peptide levels in primary care. European heart journal. Quality of care & clinical outcomes\| PubMed ID: 30452611	2019
Heart failure and right ventricular pacing - how to avoid the need for cardiac resynchronization therapy. Expert review of medical devices\| PubMed ID: 30477355	2019
Predicting one-year mortality in heart failure using the 'Surprise Question': a prospective pilot study. European journal of heart failure\| PubMed ID: 30548129	2019
Cardiac magnetic resonance in patients with cardiac resynchronization therapy: is it time to scan with resynchronization on? Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology\| PubMed ID: 30608530	2019
Heart failure: A preventable and treatable complication of type 2 diabetes. Journal of diabetes\| PubMed ID: 31037815	2019
Initiation of sacubitril/valsartan in haemodynamically stabilised heart failure patients in hospital or early after discharge: primary results of the randomised TRANSITION study. European journal of heart failure\| PubMed ID: 31134724	2019
Cardiac resynchronization therapy pacemaker or cardiac resynchronization therapy defibrillator: what determines the choice?-findings from the ESC CRT Survey II. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology\| PubMed ID: 31157387	2019
Cost-effectiveness of an insertable cardiac monitor in a high-risk population in the UK. Open heart\| PubMed ID: 31297227	2019
Optimising pacemaker therapy and medical therapy in pacemaker patients for heart failure: protocol for the OPT-PACE randomised controlled trial. BMJ open\| PubMed ID: 31320354	2019
Divergent skeletal muscle mitochondrial phenotype between male and female patients with chronic heart failure. Journal of cachexia, sarcopenia and muscle\| PubMed ID: 31430834	2020
Long-term Outcomes Are Poor in Intravenous Drug Users Following Infective Endocarditis, Even After Surgery. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 31504326	2020
The REDUCE FMR Trial: A Randomized Sham-Controlled Study of Percutaneous Mitral Annuloplasty in Functional Mitral Regurgitation. JACC. Heart failure\| PubMed ID: 31521683	2019
Futility in cardiology: the need for a change in perspectives: reply. European journal of heart failure\| PubMed ID: 31637802	2019
Initiation of sacubitril/valsartan shortly after hospitalisation for acutely decompensated heart failure in patients with newly diagnosed (de novo) heart failure: a subgroup analysis of the ... European journal of heart failure\| PubMed ID: 31820537	2020
Myocardial Effects of Aldosterone Antagonism in Heart Failure With Preserved Ejection Fraction. Journal of the American Heart Association\| PubMed ID: 31852424	2020
Chronic heart failure with diabetes mellitus is characterized by a severe skeletal muscle pathology. Journal of cachexia, sarcopenia and muscle\| PubMed ID: 31863644	2020
Impact of remote monitoring on clinical outcomes for patients with heart failure and atrial fibrillation: results from the REM-HF trial. European journal of heart failure\| PubMed ID: 31908129	2020
Cardiac resynchronization therapy following Carillon annuloplasty device for symptomatic heart failure and functional mitral regurgitation: a case report. European heart journal. Case reports\| PubMed ID: 31911977	2019
Long-Term Survival Following Transcatheter Mitral Valve Repair: Pooled Analysis of Prospective Trials with the Carillon Device. Cardiovascular revascularization medicine : including molecular interventions\| PubMed ID: 32111559	2020
Prevalence and prognostic significance of device-detected subclinical atrial fibrillation in patients with heart failure and reduced ejection fraction. International journal of cardiology\| PubMed ID: 32169346	2020
Personalized Rate-Response Programming Improves Exercise Tolerance After 6 Months in People With Cardiac Implantable Electronic Devices and Heart Failure: A Phase II Study. Circulation\| PubMed ID: 32299222	2020
Infection-Related Hospitalization in Heart Failure With Reduced Ejection Fraction: A Prospective Observational Cohort Study. Circulation. Heart failure\| PubMed ID: 32354281	2020
Transcatheter indirect mitral annuloplasty induces annular and left atrial remodelling in secondary mitral regurgitation. ESC heart failure\| PubMed ID: 32501644	2020
Implantable cardioverter-defibrillator therapy to reduce sudden cardiac death in adults with congenital heart disease: A registry study. Journal of cardiovascular electrophysiology\| PubMed ID: 32583559	2020
Direct oral anticoagulants compared to vitamin K antagonist for the management of left ventricular thrombus. ESC heart failure\| PubMed ID: 32583975	2020
Dying 'due to' or 'with' COVID-19: a cause of death analysis in hospitalised patients. Clinical medicine (London, England)\| PubMed ID: 32753516	2020
Prioritizing symptom management in the treatment of chronic heart failure. ESC heart failure\| PubMed ID: 32757363	2020
Observational data during the COVID-19 pandemic: opportunity with uncertainty. Heart (British Cardiac Society)\| PubMed ID: 32759292	2020
Feasibility and validation of trans-valvular flow derived by four-dimensional flow cardiovascular magnetic resonance imaging in pacemaker recipients. Magnetic resonance imaging\| PubMed ID: 32889092	2020
Unique Transcriptome Signature Distinguishes Patients With Heart Failure With Myopathy. Journal of the American Heart Association\| PubMed ID: 32892688	2020
Effect of disease-modifying agents and their association with mortality in multi-morbid patients with heart failure with reduced ejection fraction. ESC heart failure\| PubMed ID: 32924331	2020
Electrical weapons and rhabdomyolysis. Forensic science, medicine, and pathology\| PubMed ID: 32946064	2021
Secondary mitral regurgitation: reducing the leak, expanding the science. ESC heart failure\| PubMed ID: 33016650	2020
Measuring physical activity with activity monitors in patients with heart failure: from literature to practice. A position paper from the Committee on Exercise Physiology and Training of the... European journal of heart failure\| PubMed ID: 33111464	2021
Association of heart failure and its comorbidities with loss of life expectancy. Heart (British Cardiac Society)\| PubMed ID: 33153996	2021
Response by Gierula et al to Letter Regarding Article, "Personalized Rate-Response Programming Improves Exercise Tolerance After 6 Months in People With Cardiac Implantable Electronic Device... Circulation\| PubMed ID: 33166218	2020
Closing the loop: Delivering personalised care for patients with cryptogenic stroke. International journal of cardiology\| PubMed ID: 33221347	2021
Skeletal muscle atrophy in heart failure with diabetes: from molecular mechanisms to clinical evidence. ESC heart failure\| PubMed ID: 33225593	2021
Cost-effectiveness of an insertable cardiac monitor to detect atrial fibrillation in patients with cryptogenic stroke. Journal of comparative effectiveness research\| PubMed ID: 33300381	2021
Advanced care planning during the COVID-19 pandemic: ceiling of care decisions and their implications for observational data. BMC palliative care\| PubMed ID: 33430850	2021
To the Editor-New phones, old problem? Interference with cardiovascular implantable electronic devices by phones containing magnets. Heart rhythm\| PubMed ID: 33545390	2021
Diabetes, gender and deterioration in estimated glomerular filtration rate in patients with chronic heart failure: Ten-year prospective cohort study. Diabetes & vascular disease research\| PubMed ID: 33588611	2021
Quantifying the relationship and contribution of mitochondrial respiration to systemic exercise limitation in heart failure. ESC heart failure\| PubMed ID: 33609003	2021
Functional outcomes with Carillon device over 1 year in patients with functional mitral regurgitation of Grades 2+ to 4+: results from the REDUCE-FMR trial. ESC heart failure\| PubMed ID: 33619896	2021
Advances in cardiac resynchronization and implantable cardioverter/defibrillator therapy: Medtronic Cobalt and Crome. Future cardiology\| PubMed ID: 33635121	2021
Four pillars of heart failure: contemporary pharmacological therapy for heart failure with reduced ejection fraction. Open heart\| PubMed ID: 33653703	2021
Non-communicable disease, sociodemographic factors, and risk of death from infection: a UK Biobank observational cohort study. The Lancet. Infectious diseases\| PubMed ID: 33662324	2021
Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis. Nature communications\| PubMed ID: 33772024	2021
Burden of oral anticoagulation in embolic stroke of undetermined source without atrial fibrillation. BMC cardiovascular disorders\| PubMed ID: 33789592	2021
Detrimental Immediate- and Medium-Term Clinical Effects of Right Ventricular Pacing in Patients With Myocardial Fibrosis. Circulation. Cardiovascular imaging\| PubMed ID: 34000818	2021
Sexual dimorphism in adipose tissue mitochondrial function and metabolic flexibility in obesity. International journal of obesity (2005)\| PubMed ID: 34002038	2021
Impact of the COVID-19 pandemic on the management of chronic heart failure. Reviews in cardiovascular medicine\| PubMed ID: 34258895	2021
Impact of QRS duration on left ventricular remodelling and survival in patients with heart failure. Journal of cardiovascular medicine (Hagerstown, Md.)\| PubMed ID: 34261079	2021
Suboptimal Dosing of β-Blockers in Chronic Heart Failure: A Missed Opportunity? The Journal of cardiovascular nursing\| PubMed ID: 34321430	2022
We Do Not Talk to Patients About Their Prognosis, But Is Any of This Surprising? Journal of cardiac failure\| PubMed ID: 34324925	2021
Cost-effectiveness of insertable cardiac monitors for diagnosis of atrial fibrillation in cryptogenic stroke in Australia. Journal of arrhythmia\| PubMed ID: 34386135	2021
Empagliflozin Treatment Is Associated With Improvements in Cardiac Energetics and Function and Reductions in Myocardial Cellular Volume in Patients With Type 2 Diabetes. Diabetes\| PubMed ID: 34610982	2021
Causes of Death in People With Cardiovascular Disease: A UK Biobank Cohort Study. Journal of the American Heart Association\| PubMed ID: 34743561	2021
Heart rate, exercise capacity, and the force-frequency relationship in chronic heart failure. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology\| PubMed ID: 34849743	2022
Personalised reprogramming to prevent progressive pacemaker-related left ventricular dysfunction: A phase II randomised, controlled clinical trial. PloS one\| PubMed ID: 34898655	2021
Coenzyme Q10 to manage chronic heart failure with a reduced ejection fraction: a systematic review and economic evaluation. Health technology assessment (Winchester, England)\| PubMed ID: 35076012	2022
An enormous right atrial myxoma highlights the role of echocardiography in heart failure pathways: a case report. European heart journal. Case reports\| PubMed ID: 35233493	2022
Diabetes mellitus and the causes of hospitalisation in people with heart failure. Diabetes & vascular disease research\| PubMed ID: 35236158	2022
Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle. Nature communications\| PubMed ID: 35365625	2022
Cardiac resynchronisation therapy with or without a defibrillator: individualising device prescription. Heart (British Cardiac Society)\| PubMed ID: 35410892	2022
Designing clinical trials in heart failure with preserved ejection fraction: quality over quantity? European journal of heart failure\| PubMed ID: 35445788	2022
Systemic Inflammation Is Associated With Future Risk of Fatal Infection: An Observational Cohort Study. The Journal of infectious diseases\| PubMed ID: 35535512	2022
Surgical Techniques and Outcomes in Patients With Intra-Cardiac Abscesses Complicating Infective Endocarditis. Frontiers in cardiovascular medicine\| PubMed ID: 35711342	2022
Guideline-directed medical therapy is similarly effective in heart failure with mildly reduced ejection fraction. Clinical research in cardiology : official journal of the German Cardiac Society\| PubMed ID: 35781605	2023
Atrial fibrillation and risk of progressive heart failure in patients with preserved ejection fraction heart failure. ESC heart failure\| PubMed ID: 35790085	2022
Reduction of heart failure guideline-directed medication during hospitalization: prevalence, risk factors, and outcomes. ESC heart failure\| PubMed ID: 35796239	2022
Influence of diabetes on sacubitril/valsartan titration and clinical outcomes in patients hospitalized for heart failure. ESC heart failure\| PubMed ID: 36125177	2023
'Acute Heart Failure': Should We Abandon the Term Altogether? Current heart failure reports\| PubMed ID: 36166184	2022
Development of algorithms for determining heart failure with reduced and preserved ejection fraction using nationwide electronic healthcare records in the UK. Open heart\| PubMed ID: 36332942	2022
Clinical implications and risk factors for QRS prolongation over time in heart failure patients. Clinical research in cardiology : official journal of the German Cardiac Society\| PubMed ID: 36378295	2023
Cardiomyopathy Associated with Right Ventricular Apical Pacing-Systematic Review and Meta-Analysis. Journal of clinical medicine\| PubMed ID: 36498462	2022
Correction: Advanced care planning during the COVID-19 pandemic: ceiling of care decisions and their implications for observational data. BMC palliative care\| PubMed ID: 36527047	2022
Cost-effectiveness of an insertable cardiac monitor in a high-risk population in the US. BMC cardiovascular disorders\| PubMed ID: 36698055	2023
Remote monitoring in heart failure: it's the data you collect what you do with them. Heart (British Cardiac Society)\| PubMed ID: 36702540	2023
Atrial secondary mitral regurgitation: prevalence, characteristics, management, and long-term outcomes. Echo research and practice\| PubMed ID: 36882790	2023
It's a Matter of Fat: The Obesity Paradox in Heart Failure. The American journal of cardiology\| PubMed ID: 37884267	2023
Outcomes following cardiac resynchronisation therapy in older people. Age and ageing\| PubMed ID: 38035797	2023
Potential role of pregabalin in the treatment of episodic breathlessness. Annals of palliative medicine\| PubMed ID: 38073296	2024
Sodium-glucose cotransporter 2 inhibitors influence skeletal muscle pathology in patients with heart failure and reduced ejection fraction. European journal of heart failure\| PubMed ID: 38468429	2024