construction-an-orthotopic-xenograft-model-non-small-cell-lung-cancer

Construction of An Orthotopic Xenograft Model of Non-Small Cell Lung Cancer Mimicking Disease Progression and Predicting Drug Activities

Non-small cell lung cancer (NSCLC) is a highly lethal disease with a complex and heterogeneous tumor microenvironment. Currently, common animal models ...

University of the Pacific

To develop cationic lipid-coated magnesium phosphate nanoparticles (LPP) for intracellular catalase (CAT) delivery.

Lipid-Coated, pH-Sensitive Magnesium Phosphate Particles for Intracellular Protein Delivery.

Lung cancer leads in mortality among all types of cancer in US and Non-small cell lung cancer (NSCLC) is the major type of lung cancer. Mice models of lung cancer based on subcutaneous or orthotopic inoculation of cancer cell suspension do not adequately mimic the progression of lung cancer in clinic.

Intrapulmonary inoculation of multicellular spheroids to construct an orthotopic lung cancer xenograft model that mimics four clinical stages of non-small cell lung cancer.

Article	Year
Lipid-Coated, pH-Sensitive Magnesium Phosphate Particles for Intracellular Protein Delivery. Pharmaceutical research\| PubMed ID: 30976936	2019
Intrapulmonary inoculation of multicellular spheroids to construct an orthotopic lung cancer xenograft model that mimics four clinical stages of non-small cell lung cancer. Journal of pharmacological and toxicological methods\| PubMed ID: 32531198	2020

Yingbo Huang

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