Peter Schuck

Some reflections on the Baby M case.

The social utility of surrogacy.

Malpractice liability and the rationing of care.

Rethinking informed consent.

Elucidating kinetic and thermodynamic constants for interaction of G protein subunits and receptors by surface plasmon resonance spectroscopy.

Biochemical and biological characterization of a dodecameric CD4-Ig fusion protein: implications for therapeutic and vaccine strategies.

Size-distribution analysis of proteins by analytical ultracentrifugation: strategies and application to model systems.

Quantifying the energetics of cooperativity in a ternary protein complex.

Mass spectrometry after capture and small-volume elution of analyte from a surface plasmon resonance biosensor.

Analysis of a temperature-sensitive mutant rotavirus indicates that NSP2 octamers are the functional form of the protein.

Epidemiology research.

Modern analytical ultracentrifugation in protein science: a tutorial review.

Surface plasmon resonance-based competition assay to assess the sera reactivity of variants of humanized antibodies.

Grafting of "abbreviated" complementarity-determining regions containing specificity-determining residues essential for ligand contact to engineer a less immunogenic humanized monoclonal antibody.

Differences in the binding capacity of human apolipoprotein E3 and E4 to size-fractionated lipid emulsions.

Inhibition of hemostasis by a high affinity biogenic amine-binding protein from the saliva of a blood-feeding insect.

Combined affinity and rate constant distributions of ligand populations from experimental surface binding kinetics and equilibria.

Alanine-scanning mutations in domain 4 of anthrax toxin protective antigen reveal residues important for binding to the cellular receptor and to a neutralizing monoclonal antibody.

The 'smallest real difference' as a measure of sensitivity to change: a critical analysis.

On the analysis of protein self-association by sedimentation velocity analytical ultracentrifugation.

Reversible and fast association equilibria of a molecular chaperone, gp57A, of bacteriophage T4.

Minimizing immunogenicity of the SDR-grafted humanized antibody CC49 by genetic manipulation of the framework residues.

Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2K(b).

In vitro affinity maturation of a specificity-determining region-grafted humanized anticarcinoma antibody: isolation and characterization of minimally immunogenic high-affinity variants.

Sedimentation equilibrium analysis of protein interactions with global implicit mass conservation constraints and systematic noise decomposition.

A model for sedimentation in inhomogeneous media. I. Dynamic density gradients from sedimenting co-solutes.

A model for sedimentation in inhomogeneous media. II. Compressibility of aqueous and organic solvents.

Binding specificity of multiprotein signaling complexes is determined by both cooperative interactions and affinity preferences.

Calculating sedimentation coefficient distributions by direct modeling of sedimentation velocity concentration profiles.

Assessing reproducibility for interval data in health-related quality of life questionnaires: which coefficient should be used?

Crystal structure of the C-terminal peptidoglycan-binding domain of human peptidoglycan recognition protein Ialpha.

SDR grafting of a murine antibody using multiple human germline templates to minimize its immunogenicity.

Case histories illustrating the utility of sertindole in clinical practice.

Studying multiprotein complexes by multisignal sedimentation velocity analytical ultracentrifugation.

Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin alphaXbeta2.

Targeted lysis of HIV-infected cells by natural killer cells armed and triggered by a recombinant immunoglobulin fusion protein: implications for immunotherapy.

Cooperative behavior of Escherichia coli cell-division protein FtsZ assembly involves the preferential cyclization of long single-stranded fibrils.

Characterization of DC-SIGN/R interaction with human immunodeficiency virus type 1 gp120 and ICAM molecules favors the receptor's role as an antigen-capturing rather than an adhesion receptor.

Eukaryotic RNases H1 act processively by interactions through the duplex RNA-binding domain.

Sedimentation velocity analysis of heterogeneous protein-protein interactions: sedimentation coefficient distributions c(s) and asymptotic boundary profiles from Gilbert-Jenkins theory.

Sedimentation velocity analysis of heterogeneous protein-protein interactions: Lamm equation modeling and sedimentation coefficient distributions c(s).

A mechanism for assembly of complexes of vitronectin and plasminogen activator inhibitor-1 from sedimentation velocity analysis.

Self-association and ligand-induced conformational changes of iron regulatory proteins 1 and 2.

Regulation of ASAP1 by phospholipids is dependent on the interface between the PH and Arf GAP domains.

Dissection of merozoite surface protein 3, a representative of a family of Plasmodium falciparum surface proteins, reveals an oligomeric and highly elongated molecule.

Influence of temperature on the conformation of canine plasminogen: an analytical ultracentrifugation and dynamic light scattering study.

Chimpanzee/human mAbs to vaccinia virus B5 protein neutralize vaccinia and smallpox viruses and protect mice against vaccinia virus.

Efficient neutralization of anthrax toxin by chimpanzee monoclonal antibodies against protective antigen.

Crystal structure of group A streptococcus Mac-1: insight into dimer-mediated specificity for recognition of human IgG.

Quaternary structure and cleavage specificity of a poxvirus holliday junction resolvase.

Macromolecular size-and-shape distributions by sedimentation velocity analytical ultracentrifugation.

Variable dimerization of the Ly49A natural killer cell receptor results in differential engagement of its MHC class I ligand.

Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1.

Conformational restriction blocks glutamate receptor desensitization.

Probing the functional heterogeneity of surface binding sites by analysis of experimental binding traces and the effect of mass transport limitation.

Studying multisite binary and ternary protein interactions by global analysis of isothermal titration calorimetry data in SEDPHAT: application to adaptor protein complexes in cell signaling.

Superantigen natural affinity maturation revealed by the crystal structure of staphylococcal enterotoxin G and its binding to T-cell receptor Vbeta8.2.

Single-walled tubulin ring polymers.

Using prior knowledge in the determination of macromolecular size-distributions by analytical ultracentrifugation.

Characterization of chimpanzee/human monoclonal antibodies to vaccinia virus A33 glycoprotein and its variola virus homolog in vitro and in a vaccinia virus mouse protection model.

Cellular expression and crystal structure of the murine cytomegalovirus major histocompatibility complex class I-like glycoprotein, m153.

Two interferons alpha influence each other during their interaction with the extracellular domain of human type interferon receptor subunit 2.

Extended polypeptide linkers establish the spatial architecture of a pyruvate dehydrogenase multienzyme complex.

Bacteriorhodopsin/amphipol complexes: structural and functional properties.

A new adaptive grid-size algorithm for the simulation of sedimentation velocity profiles in analytical ultracentrifugation.

Apolipoprotein C-II amyloid fibrils assemble via a reversible pathway that includes fibril breaking and rejoining.

Measuring protein interactions by optical biosensors.

Measuring protein-protein interactions by equilibrium sedimentation.

Humanized monoclonal antibodies derived from chimpanzee Fabs protect against Japanese encephalitis virus in vitro and in vivo.

Characterizing protein-protein interactions by sedimentation velocity analytical ultracentrifugation.

A bayesian approach for quantifying trace amounts of antibody aggregates by sedimentation velocity analytical ultracentrifugation.

Bayesian analysis of heterogeneity in the distribution of binding properties of immobilized surface sites.

Autoinhibition of Arf GTPase-activating protein activity by the BAR domain in ASAP1.

Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization.

The C-terminal domain of Plasmodium falciparum merozoite surface protein 3 self-assembles into alpha-helical coiled coil tetramer.

The N-terminal domain of GluR6-subtype glutamate receptor ion channels.

Novel chimpanzee/human monoclonal antibodies that neutralize anthrax lethal factor, and evidence for possible synergy with anti-protective antigen antibody.

NanoPen: dynamic, low-power, and light-actuated patterning of nanoparticles.

Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ions.

On the analysis of sedimentation velocity in the study of protein complexes.

On computational approaches for size-and-shape distributions from sedimentation velocity analytical ultracentrifugation.

Direct interaction of the mouse cytomegalovirus m152/gp40 immunoevasin with RAE-1 isoforms.

Some statistical properties of differencing schemes for baseline correction of sedimentation velocity data.

The role of mass transport limitation and surface heterogeneity in the biophysical characterization of macromolecular binding processes by SPR biosensing.

Phospholipids enhance nucleation but not elongation of apolipoprotein C-II amyloid fibrils.

Sedimentation patterns of rapidly reversible protein interactions.

Accounting for solvent signal offsets in the analysis of interferometric sedimentation velocity data.

Diffusion of the reaction boundary of rapidly interacting macromolecules in sedimentation velocity.

Cooperative interactions at the SLP-76 complex are critical for actin polymerization.

Macromol. Biosci. 7/2010.

Biophysical characterization of DNA and RNA aptamer interactions with hen egg lysozyme.

Extended Fujita approach to the molecular weight distribution of polysaccharides and other polymeric systems.

The boundary structure in the analysis of reversibly interacting systems by sedimentation velocity.

Dimeric states of neural- and epithelial-cadherins are distinguished by the rate of disassembly.

Editorial for the special issue of methods "Modern Analytical Ultracentrifugation".

On the distribution of protein refractive index increments.

The role of macromolecular crowding in the evolution of lens crystallins with high molecular refractive index.

Radiation engineering of optical antennas for maximum field enhancement.

The molecular refractive function of lens γ-Crystallins.

Structure and assembly mechanism for heteromeric kainate receptors.

Malaria vaccine candidate: design of a multivalent subunit α-helical coiled coil poly-epitope.

NBD-labeled phospholipid accelerates apolipoprotein C-II amyloid fibril formation but is not incorporated into mature fibrils.

Density contrast sedimentation velocity for the determination of protein partial-specific volumes.

Structural, Bioinformatic, and In Vivo Analyses of Two Treponema pallidum Lipoproteins Reveal a Unique TRAP Transporter.