Thomas Krieg

Treatment of recalcitrant cicatricial pemphigoid with the tumor necrosis factor alpha antagonist etanercept.

Integrin alpha 2-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen.

Role of postoperative radiotherapy in the management of Merkel cell carcinoma.

Defective laminin 5 processing in cylindroma cells.

Identification of activated matrix metalloproteinase-2 (MMP-2) as the main gelatinolytic enzyme in malignant melanoma by in situ zymography.

TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2.

Distinct in vivo expression patterns of survivin splice variants in renal cell carcinomas.

Expression of matrilin-2 in human skin.

Integrin expression in the dermis during scar formation in humans.

ACh and adenosine activate PI3-kinase in rabbit hearts through transactivation of receptor tyrosine kinases.

A patient with hyper-IgE syndrome: a multisystem disorder.

Generation of a novel proteolysis resistant vascular endothelial growth factor165 variant by a site-directed mutation at the plasmin sensitive cleavage site.

Treatment of chronic wounds: state of the art and future concepts.

Acral erythrodysesthesia syndrome caused by intravenous infusion of docetaxel in breast cancer.

Exacerbation of pemphigus foliaceus after tetanus vaccination accompanied by synthesis of auto-antibodies against paraneoplastic pemphigus antigens.

Long-term efficacy, curative potential, and prognostic factors of radiotherapy in primary cutaneous B-cell lymphoma.

Activation of Akt is essential for acetylcholine to trigger generation of oxygen free radicals.

Invasion of melanoma cells into dermal connective tissue in vitro: evidence for an important role of cysteine proteases.

Multiple integrin-ligand interactions synergize in shear-resistant platelet adhesion at sites of arterial injury in vivo.

Mitochondria and their role in preconditioning's trigger phase.

Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoKATP channel opening and leads to cardioprotection.

P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts.

CD4+ T cell-associated pathophysiology critically depends on CD18 gene dose effects in a murine model of psoriasis.

Increased expression of VEGF in glomeruloid reactive angioendotheliomatosis.

Expression of pro-inflammatory markers by human dermal fibroblasts in a three-dimensional culture model is mediated by an autocrine interleukin-1 loop.

Calcinosis of the cutis and subcutis: an unusual nonimmunologic adverse reaction to subcutaneous injections of low-molecular-weight calcium-containing heparins.

NECA and bradykinin at reperfusion reduce infarction in rabbit hearts by signaling through PI3K, ERK, and NO.

Mitochondrial ROS generation following acetylcholine-induced EGF receptor transactivation requires metalloproteinase cleavage of proHB-EGF.

Correlation of hMLH1 and HPP1 hypermethylation in gastric, but not in esophageal and cardiac adenocarcinoma.

Keratin 14 Cre transgenic mice authenticate keratin 14 as an oocyte-expressed protein.

Complete remission of Merkel cell carcinoma of the scalp with local and regional metastases after topical treatment with dinitrochlorbenzol.

Myofibroblast differentiation is induced in keratinocyte-fibroblast co-cultures and is antagonistically regulated by endogenous transforming growth factor-beta and interleukin-1.

Treatment of reticular erythematous mucinosis with UV-A1 radiation.

Panniculitis induced by specific venom immunotherapy.

Dissecting the roles of endothelin, TGF-beta and GM-CSF on myofibroblast differentiation by keratinocytes.

XIAP expression is an independent prognostic marker in clear-cell renal carcinomas.

Overexpression of phospholipid-hydroperoxide glutathione peroxidase in human dermal fibroblasts abrogates UVA irradiation-induced expression of interstitial collagenase/matrix metalloproteinase-1 by suppression of phosphatidylcholine hydroperoxide-mediated NFkappaB activation and interleukin-6 release.

Acetylcholine and bradykinin trigger preconditioning in the heart through a pathway that includes Akt and NOS.

Gene transfer in tissue repair: status, challenges and future directions.

Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways.

Increased levels of the soluble variant of the vascular endothelial growth factor receptor VEGFR-1 are associated with a poor prognosis in wound healing.

High plasminogen activator inhibitor type 2 expression is a hallmark of scleroderma fibroblasts in vitro.

Anti-glycoprotein VI treatment severely compromises hemostasis in mice with reduced alpha2beta1 levels or concomitant aspirin therapy.

T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation.

Peptide blockers of PKG inhibit ROS generation by acetylcholine and bradykinin in cardiomyocytes but fail to block protection in the whole heart.

Genetically modified mice as a tool to study inflammatory skin diseases.

Silicone granuloma of the face treated with minocycline.

High invasive melanoma cells induce matrix metalloproteinase-1 synthesis in fibroblasts by interleukin-1alpha and basic fibroblast growth factor-mediated mechanisms.

E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions.

Efficacy and safety of the freeze-dried cultured human keratinocyte lysate, LyphoDerm 0.9%, in the treatment of hard-to-heal venous leg ulcers.

Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo.

Human scalp dermal papilla and fibrous sheath cells have a different expression profile of matrix metalloproteinases in vitro when compared to scalp dermal fibroblasts.

Wound-healing defect of CD18(-/-) mice due to a decrease in TGF-beta1 and myofibroblast differentiation.

Ras-induced spreading and wound closure in human epidermal keratinocytes.

[Treatment of chronic actinic dermatitis with mycophenolate mofetil].

[Lymphocytic infiltration after oral administration of tamsulosin (Alna)].

Absence of autoantibodies against correctly folded recombinant fibrillin-1 protein in systemic sclerosis patients.

Keloids--clinical diagnosis, pathogenesis, and treatment options.

Signalling and regulation of collagen I synthesis by ET-1 and TGF-beta1.

Expression of matrix metalloproteinase (MMP)-2, MMP-9, MMP-13, and MT1-MMP in skin tumors of human papillomavirus type 8 transgenic mice.

Protection through postconditioning or a mitochondria-targeted S-nitrosothiol is unaffected by cardiomyocyte-selective ablation of protein kinase G.

[The clinical spectrum of dermatomyositis].

Contact of high-invasive, but not low-invasive, melanoma cells to native collagen I induces the release of mature cathepsin B.

Localized inflammatory skin disease following inducible ablation of I kappa B kinase 2 in murine epidermis.

Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling.

Phosphodiesterase type 5 inhibition is a novel therapeutic option in Raynaud disease.

Senescence of human fibroblasts after psoralen photoactivation is mediated by ATR kinase and persistent DNA damage foci at telomeres.

Plasmin modulates vascular endothelial growth factor-A-mediated angiogenesis during wound repair.

Expression of laminin 5 by parental and c-Ha-ras-transformed HaCaT keratinocytes in organotypic cultures.

A human keratin 10 knockout causes recessive epidermolytic hyperkeratosis.

NECA at reperfusion limits infarction and inhibits formation of the mitochondrial permeability transition pore by activating p70S6 kinase.

Interactions of primary fibroblasts and keratinocytes with extracellular matrix proteins: contribution of alpha2beta1 integrin.

[Assymetric pigmental lesions on the underarm and quickly growing nodes on the back of the hand].

Novel and recurrent mutations in keratin KRT5 and KRT14 genes in epidermolysis bullosa simplex: implications for disease phenotype and keratin filament assembly.

A novel property of povidon-iodine: inhibition of excessive protease levels in chronic non-healing wounds.

Terminal B cell differentiation is skewed by deregulated interleukin-6 secretion in beta2 integrin-deficient mice.

Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation.

Integrin alpha2beta1 deficiency does not affect contact hypersensitivity.

Integrin alpha2beta1 is required for regulation of murine wound angiogenesis but is dispensable for reepithelialization.

Identification of susceptibility loci for skin disease in a murine psoriasis model.

Immunoadsorption in dilated cardiomyopathy: 6-month results from a randomized study.

Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis.

Mechanical tension and integrin alpha 2 beta 1 regulate fibroblast functions.

Molecular mechanisms of VEGF-A action during tissue repair.

Trichilemmal cyst nevus: a new complex organoid epidermal nevus.

Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA.

Accelerated wound closure in mice deficient for interleukin-10.

Morphometric analysis of murine skin wound healing: standardization of experimental procedures and impact of an advanced multitissue array technique.

Gene therapy and wound healing.

Preconditioning-mimetics bradykinin and DADLE activate PI3-kinase through divergent pathways.

Inflammation in wound repair: molecular and cellular mechanisms.

Outcome measurements in scleroderma: results from a delphi exercise.

Impaired epidermal wound healing in vivo upon inhibition or deletion of Rac1.

Keratinocyte-fibroblast interactions in wound healing.

Scleroderma -- news to tell.

New developments in fibroblast and myofibroblast biology: implications for fibrosis and scleroderma.

The delta-opioid receptor agonist DADLE at reperfusion protects the heart through activation of pro-survival kinases via EGF receptor transactivation.

COX-2-dependent and potentially cardioprotective effects of negative inotropic substances released after ischemia.

Gene expression profiling of lichen planus reflects CXCL9+-mediated inflammation and distinguishes this disease from atopic dermatitis and psoriasis.

Fibrosis in connective tissue disease: the role of the myofibroblast and fibroblast-epithelial cell interactions.

Mast cell-specific Cre/loxP-mediated recombination in vivo.

The endothelin receptor blocker bosentan inhibits doxorubicin-induced cardiomyopathy.

Making the heart resistant to infarction: how can we further decrease infarct size?

African tick bite fever--papulovesicular exanthem with fever after staying in South Africa.

Integrin alpha2beta1 is the required receptor for endorepellin angiostatic activity.

Toll-like receptor-4 deficiency attenuates doxorubicin-induced cardiomyopathy in mice.

Mapping preconditioning's signaling pathways: an engineering approach.

Pustulosis acuta generalisata with joint involvement in an HLA-A2- and HLA-B35-positive patient.

The inhibition of matrix metalloproteinase activity in chronic wounds by a polyacrylate superabsorber.

Discordant response to rituximab in a systemic sclerosis patient with associated myositis.

Transcriptional profiling identifies an interferon-associated host immune response in invasive squamous cell carcinoma of the skin.

High frequency of corticosteroid and immunosuppressive therapy in patients with systemic sclerosis despite limited evidence for efficacy.

Classical cadherins regulate desmosome formation.

Alternative proteolytic processing of hepatocyte growth factor during wound repair.

Interrelation of immunity and tissue repair or regeneration.

BAY 58-2667, a nitric oxide-independent guanylyl cyclase activator, pharmacologically post-conditions rabbit and rat hearts.

Scleroderma.

Recessive epidermolytic hyperkeratosis caused by a previously unreported termination codon mutation in the keratin 10 gene.

[AWMF Guideline no. 013/066. Diagnosis and therapy of circumscribed scleroderma].

AMP579 is revealed to be a potent A2b-adenosine receptor agonist in human 293 cells and rabbit hearts.

Merkel cell polyomavirus DNA in persons without merkel cell carcinoma.

Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity.

Cardioprotective effects of mineralocorticoid receptor antagonists at reperfusion.

Differential roles of macrophages in diverse phases of skin repair.

Cell-matrix interactions in dermal repair and scarring.

Home telemonitoring in patients with chronic heart failure: a chance to improve patient care?

Inhibition of glycogen synthase kinase 3beta prevents peroxide-induced collapse of mitochondrial membrane potential in rat ventricular myocytes.

Scleroderma: from pathophysiology to novel therapeutic approaches.

Differential proteomic analysis distinguishes tissue repair biomarker signatures in wound exudates obtained from normal healing and chronic wounds.

Both A2a and A2b adenosine receptors at reperfusion are necessary to reduce infarct size in mouse hearts.

Expression of integrin beta1 by fibroblasts is required for tissue repair in vivo.

Imatinib treatment of generalized localized scleroderma (morphea).

Migration of epithelial cells on laminins: RhoA antagonizes directionally persistent migration.

Defective granulation tissue formation in mice with specific ablation of integrin-linked kinase in fibroblasts - role of TGFβ1 levels and RhoA activity.

A2b adenosine receptors in cardioprotection: timing is everything.

Registries in systemic sclerosis: a worldwide experience.

Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit.

Evidence for an intracellular localization of the adenosine A2B receptor in rat cardiomyocytes.

Mild recessive dystrophic epidermolysis bullosa associated with two compound heterozygous COL7A1 mutations.

A case of linear porokeratosis superimposed on disseminated superficial actinic porokeratosis.

The extracellular matrix of the dermis: flexible structures with dynamic functions.

Collagen XXIII, novel ligand for integrin alpha2beta1 in the epidermis.

Pivotal role for alpha1-antichymotrypsin in skin repair.

Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens.

Elevated MMP-7 levels in patients with systemic sclerosis: correlation with pulmonary involvement.

The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells.

All preconditioning-related G protein-coupled receptors can be demonstrated in the rabbit cardiomyocyte.

Combination therapy with an endothelin-1 receptor antagonist (bosentan) and a phosphodiesterase V inhibitor (sildenafil) for the management of severe digital ulcerations in systemic sclerosis.

Differential roles for Chk1 and FANCD2 in ATR-mediated signalling for psoralen photoactivation-induced senescence.

Frequency of disease-associated and other nuclear autoantibodies in patients of the German Network for Systemic Scleroderma: correlation with characteristic clinical features.

Dwarfism in mice lacking collagen-binding integrins α2β1 and α11β1 is caused by severely diminished IGF-1 levels.

Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry.

A function for Rac1 in the terminal differentiation and pigmentation of hair.

A decreased ratio between serum levels of the antagonistic angiopoietins 1 and 2 indicates tumour progression of malignant melanoma.

Vascular endothelial insulin/IGF-1 signaling controls skin wound vascularization.

Collagen XII and XIV, new partners of cartilage oligomeric matrix protein in the skin extracellular matrix suprastructure.

CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair.

Stromal fibroblast-specific expression of ADAM-9 modulates proliferation and apoptosis in melanoma cells in vitro and in vivo.

Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis.

Oxidative and nitrosative stress in the maintenance of myocardial function.

Experimental analysis of risk factors for ulcerative dermatitis in mice.

Cyclic mechanical stress downregulates endothelin-1 and its responsive genes independently of TGFβ1 in dermal fibroblasts.

Epidermal expression of neuropilin 1 protects murine keratinocytes from UVB-induced apoptosis.

A fast protocol for infarct quantification in mice.

Enhanced deposition of cartilage oligomeric matrix protein is a common feature in fibrotic skin pathologies.

Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response.

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I.

Using exomarkers to assess mitochondrial reactive species in vivo.

Functional impairment of systemic scleroderma patients with digital ulcerations: results from the DUO Registry.

A mitochondria-targeted mass spectrometry probe to detect glyoxals: Implications for diabetes.