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Embryonic stem cells in predictive cardiotoxicity: laser capture microscopy enables assay development.
Toxicological sciences : an official journal of the Society of Toxicology Mar, 2006 | Pubmed ID: 16357009
Evaluation of the rubidium efflux assay for preclinical identification of HERG blockade.
Assay and drug development technologies Feb, 2006 | Pubmed ID: 16506891
Ca2+-independent alterations in diastolic sarcomere length and relaxation kinetics in a mouse model of lipotoxic diabetic cardiomyopathy.
Circulation research Jan, 2009 | Pubmed ID: 19023131
Effect of compound plate composition on measurement of hERG current IC(50) using PatchXpress.
Journal of pharmacological and toxicological methods Jul-Aug, 2009 | Pubmed ID: 19442753
Palmitate attenuates myocardial contractility through augmentation of repolarizing Kv currents.
Journal of molecular and cellular cardiology Feb, 2010 | Pubmed ID: 19857498
Discovery of ((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxy-tetrahydro-2H-pyran-4-ylamino)cyclopentyl)(4-(5-(trifluoromethyl)pyridazin-3-yl)piperazin-1-yl)methanone, PF-4254196, a CCR2 antagonist with an improved cardiovascular profile.
Bioorganic & medicinal chemistry letters May, 2011 | Pubmed ID: 21315584
A mini-microscope for in situ monitoring of cells.
Lab on a chip Oct, 2012 | Pubmed ID: 22911426
Clear castable polyurethane elastomer for fabrication of microfluidic devices.
Lab on a chip Aug, 2013 | Pubmed ID: 23954953
Microfabrication of human organs-on-chips.
Nature protocols Nov, 2013 | Pubmed ID: 24113786
State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology.
ALTEX , 2014 | Pubmed ID: 25027500
Organs-on-chips at the frontiers of drug discovery.
Nature reviews. Drug discovery Apr, 2015 | Pubmed ID: 25792263
Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro.
Nature methods Feb, 2016 | Pubmed ID: 26689262
Modeling Hematopoiesis and Responses to Radiation Countermeasures in a Bone Marrow-on-a-Chip.
Tissue engineering. Part C, Methods May, 2016 | Pubmed ID: 26993746
Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing.
ALTEX , 2016 | Pubmed ID: 27180100
1Department of Biomedical Engineering, The University of Texas at Austin,
2, Wyss Institute for Biologically Inspired Engineering at Harvard University,
3Vascular Biology Program, Boston Children's Hospital, Harvard Medical School,
4John A. Paulson School of Engineering and Applied Sciences, Harvard University