Herbert Irving Comprehensive Cancer Center,
Organoid and Cell Culture Core,
Columbia University Digestive and Liver Diseases Research Center,
Division of Digestive and Liver Diseases,
Department of Medicine,
Organoid and Cell Culture Core, Columbia University Digestive and Liver Diseases Research Center,
Division of Digestive and Liver Diseases, Department of Medicine
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Optical imaging of periostin enables early endoscopic detection and characterization of esophageal cancer in mice.
Gastroenterology Feb, 2013 | Pubmed ID: 23085486
Inhibition of Notch signaling enhances transdifferentiation of the esophageal squamous epithelium towards a Barrett's-like metaplasia via KLF4.
Cell cycle (Georgetown, Tex.) , 2014 | Pubmed ID: 25558829
Immature myeloid progenitors promote disease progression in a mouse model of Barrett's-like metaplasia.
Oncotarget Oct, 2015 | Pubmed ID: 26460825
Autophagy mediates epithelial cytoprotection in eosinophilic oesophagitis.
Gut Jul, 2017 | Pubmed ID: 26884425
Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration.
The Journal of clinical investigation Jun, 2017 | Pubmed ID: 28481227
Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma.
Nature communications Nov, 2017 | Pubmed ID: 29170450
Persistent Basal Cell Hyperplasia Is Associated With Clinical and Endoscopic Findings in Patients With Histologically Inactive Eosinophilic Esophagitis.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Jun, 2020 | Pubmed ID: 31499251
Esophageal 3D organoids of mouse model of mitochondrial DNA depletion show epithelial cell plasticity and telomere attrition.
Oncotarget Oct, 2019 | Pubmed ID: 31692873
Use of hPSC-derived 3D organoids and mouse genetics to define the roles of YAP in the development of the esophagus.
Development (Cambridge, England) Dec, 2019 | Pubmed ID: 31748205
Outcomes of patients with submucosal (T1b) esophageal adenocarcinoma: a multicenter cohort study.
Gastrointestinal endoscopy Jul, 2020 | Pubmed ID: 31953189
Modeling Epithelial Homeostasis and Reactive Epithelial Changes in Human and Murine Three-Dimensional Esophageal Organoids.
Current protocols in stem cell biology Mar, 2020 | Pubmed ID: 32105412
Generation and Characterization of Patient-Derived Head and Neck, Oral, and Esophageal Cancer Organoids.
Current protocols in stem cell biology Jun, 2020 | Pubmed ID: 32294323
Notch Signaling Mediates Differentiation in Barrett's Esophagus and Promotes Progression to Adenocarcinoma.
Gastroenterology Aug, 2020 | Pubmed ID: 32325086
Olig2-Induced Semaphorin Expression Drives Corticospinal Axon Retraction After Spinal Cord Injury.
Cerebral cortex (New York, N.Y. : 1991) Oct, 2020 | Pubmed ID: 32564090
Autophagy mitigates ethanol-induced mitochondrial dysfunction and oxidative stress in esophageal keratinocytes.
PloS one , 2020 | Pubmed ID: 32966340
Mitochondrial dysfunction in inflammatory bowel disease alters intestinal epithelial metabolism of hepatic acylcarnitines.
The Journal of clinical investigation Jan, 2021 | Pubmed ID: 33141762
Rab11-FIP1 mediates epithelial-mesenchymal transition and invasion in esophageal cancer.
EMBO reports Feb, 2021 | Pubmed ID: 33403789
MicroRNA-Based Cancer Mortality Risk Scoring System and hTERT Expression in Early-Stage Oral Squamous Cell Carcinoma.
Journal of oncology , 2021 | Pubmed ID: 33510789
Mutant p53 regulates Survivin to foster lung metastasis.
Genes & development Apr, 2021 | Pubmed ID: 33737385
Pan-ERBB kinase inhibition augments CDK4/6 inhibitor efficacy in oesophageal squamous cell carcinoma.
Gut Apr, 2022 | Pubmed ID: 33789967
Understanding the cellular origin and progression of esophageal cancer using esophageal organoids.
Cancer letters Jul, 2021 | Pubmed ID: 33838281
Reprogramming of the esophageal squamous carcinoma epigenome by SOX2 promotes ADAR1 dependence.
Nature genetics Jun, 2021 | Pubmed ID: 33972779
NOTCH3 limits the epithelial-mesenchymal transition and predicts a favorable clinical outcome in esophageal cancer.
Cancer medicine Jun, 2021 | Pubmed ID: 34042293
Stem cells and origins of cancer in the upper gastrointestinal tract.
Cell stem cell Aug, 2021 | Pubmed ID: 34129814
FANCD2 limits acetaldehyde-induced genomic instability during DNA replication in esophageal keratinocytes.
Molecular oncology Nov, 2021 | Pubmed ID: 34328261
Alcohol Metabolism Enriches Squamous Cell Carcinoma Cancer Stem Cells That Survive Oxidative Stress via Autophagy.
Biomolecules Oct, 2021 | Pubmed ID: 34680112
Patient-derived organoids as a platform for modeling a patient's response to chemoradiotherapy in esophageal cancer.
Scientific reports Oct, 2021 | Pubmed ID: 34716381
3D Organoids: An Untapped Platform for Studying Host-Microbiome Interactions in Esophageal Cancers.
Microorganisms Oct, 2021 | Pubmed ID: 34835308
CD73 Epithelial Progenitor Cells That Contribute to Homeostasis and Renewal Are Depleted in Eosinophilic Esophagitis.
Cellular and molecular gastroenterology and hepatology , 2022 | Pubmed ID: 35108658
Detergent exposure induces epithelial barrier dysfunction and eosinophilic inflammation in the esophagus.
Allergy Jul, 2022 | Pubmed ID: 35899466
HPV E6 regulates therapy responses in oropharyngeal cancer by repressing the PGC-1α/ERRα axis.
JCI insight Sep, 2022 | Pubmed ID: 36134662
Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation.
Nature communications Nov, 2022 | Pubmed ID: 36329064
Samuel Flashner*,1,
Cecilia Martin*,1,2,
Norihiro Matsuura1,
Masataka Shimonosono1,
Yasuto Tomita1,
Masaki Morimoto1,
Ogoegbunam Okolo1,
Victoria X. Yu1,3,
Anuraag S. Parikh1,3,
Andres J. P. Klein-Szanto4,
Kelley Yan1,2,
Joel T. Gabre1,5,
Chao Lu1,6,
Fatemeh Momen-Heravi1,7,
Anil K. Rustgi1,5,
Hiroshi Nakagawa1,2,5
1Herbert Irving Comprehensive Cancer Center, Columbia University,
2Organoid and Cell Culture Core, Columbia University Digestive and Liver Diseases Research Center, Columbia University,
3Department of Otolaryngology, Head and Neck Surgery, Columbia University,
4Histopathology Facility, Fox Chase Cancer Center,
5Division of Digestive and Liver Diseases, Department of Medicine, Columbia University,
6Department of Genetics and Development, Columbia University,
7Section of Oral, Diagnostic and Rehabilitation Sciences, College of Dental Medicine, Columbia University