John S. Condeelis

A new strategy for caging proteins regulated by kinases.

Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling.

GFP expression in the mammary gland for imaging of mammary tumor cells in transgenic mice.

Gene expression analysis on small numbers of invasive cells collected by chemotaxis from primary mammary tumors of the mouse.

Cofilin promotes actin polymerization and defines the direction of cell motility.

Over-expression of the p110beta but not p110alpha isoform of PI 3-kinase inhibits motility in breast cancer cells.

Breast cancer cells isolated by chemotaxis from primary tumors show increased survival and resistance to chemotherapy.

Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors.

Tumor cells caught in the act of invading: their strategy for enhanced cell motility.

Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop.

The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors.

Initiation of cofilin activity in response to EGF is uncoupled from cofilin phosphorylation and dephosphorylation in carcinoma cells.

ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo.

Molecular cloning of hMena (ENAH) and its splice variant hMena+11a: epidermal growth factor increases their expression and stimulates hMena+11a phosphorylation in breast cancer cell lines.

Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors.

The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration.

Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells.

ZBP1 enhances cell polarity and reduces chemotaxis.

EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells.

RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells.

Mechanisms and cellular roles of local protein synthesis in mammalian cells.

Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo.

A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis.

Tumor microenvironment of metastasis in human breast carcinoma: a potential prognostic marker linked to hematogenous dissemination.

Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase.

Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor.

Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors.

AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment.

A new chemotaxis device for cell migration studies.

Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors.

Imaging real-time gene expression in Mammalian cells with single-transcript resolution.

Imaging real-time gene expression in living yeast.

Imaging real-time gene expression in living systems with single-transcript resolution: image analysis of single mRNA transcripts.

Imaging Real-Time Gene Expression in Living Systems with Single-Transcript Resolution: Single mRNA Particle Tracking with ImageJ-Based Analysis.

Imaging real-time gene expression in living systems with single-transcript resolution: construct design and imaging system setup.

Mena invasive (Mena(INV)) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM.

Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer.

Chemotaxis in cancer.

A photoswitchable orange-to-far-red fluorescent protein, PSmOrange.

An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype.

Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis.

Correlated Immunohistochemical and Cytological Assays for the Prediction of Hematogenous Dissemination of Breast Cancer.

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function.

A FRET-facilitated photoswitching using an orange fluorescent protein with the fast photoconversion kinetics.

Quantitative assessment of invasive mena isoforms (Menacalc) as an independent prognostic marker in breast cancer.

Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients.

Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells.

Wiskott-Aldrich syndrome protein regulates leukocyte-dependent breast cancer metastasis.

Filamin A interacting protein 1-like inhibits WNT signaling and MMP expression to suppress cancer cell invasion and metastasis.

Reconstitution of in vivo macrophage-tumor cell pairing and streaming motility on one-dimensional micro-patterned substrates.

Spatial regulation of tumor cell protrusions by RhoC.

Invadopodia in context.

Tumor microenvironment of metastasis and risk of distant metastasis of breast cancer.

Metastatic cells: moving onco-targets.

An in vitro one-dimensional assay to study growth factor-regulated tumor cell-macrophage interaction.

Intravital multiphoton imaging reveals multicellular streaming as a crucial component of in vivo cell migration in human breast tumors.

Development path and current status of the NANIVID: a new device for cancer cell studies.

Invasive breast carcinoma cells from patients exhibit MenaINV- and macrophage-dependent transendothelial migration.

Menacalc, a quantitative method of metastasis assessment, as a prognostic marker for axillary node-negative breast cancer.

Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA.

PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena.

Characterization of the expression of the pro-metastatic Mena(INV) isoform during breast tumor progression.

3-D individual cell based computational modeling of tumor cell-macrophage paracrine signaling mediated by EGF and CSF-1 gradients.

GPCR Signaling Mediates Tumor Metastasis via PI3Kβ.

Signatures of breast cancer metastasis at a glance.

Black race and distant recurrence after neoadjuvant or adjuvant chemotherapy in breast cancer.

Validation of an Automated Quantitative Digital Pathology Approach for Scoring TMEM, a Prognostic Biomarker for Metastasis.

Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells.

Combining TMEM Doorway Score and Mena Score Improves the Prediction of Distant Recurrence Risk in HR+/HER2- Breast Cancer Patients.

Racial disparity in distant recurrence-free survival in patients with localized breast cancer: A pooled analysis of National Surgical Adjuvant Breast and Bowel Project trials.

Assessment of MRI to estimate metastatic dissemination risk and prometastatic effects of chemotherapy.

Interleukin 4 Controls the Pro-Tumoral Role of Macrophages in Mammary Cancer Pulmonary Metastasis in Mice.

Intravital imaging to study cancer progression and metastasis.

Cooperative NF-κB and Notch1 signaling promotes macrophage-mediated MenaINV expression in breast cancer.

Macrophages Promote Tumor Cell Extravasation across an Endothelial Barrier through Thin Membranous Connections.

Racial disparity in tumor microenvironment and distant recurrence in residual breast cancer after neoadjuvant chemotherapy.