Department of Orthopaedic Surgery,
Department of Molecular & Integrative Physiology
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Physiological loading of tendons induces scleraxis expression in epitenon fibroblasts.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society Apr, 2012 | Pubmed ID: 21913219
Transforming growth factor-beta induces skeletal muscle atrophy and fibrosis through the induction of atrogin-1 and scleraxis.
Muscle & nerve Jan, 2012 | Pubmed ID: 22190307
Mechanical loading and TGF-β change the expression of multiple miRNAs in tendon fibroblasts.
Journal of applied physiology (Bethesda, Md. : 1985) Jul, 2012 | Pubmed ID: 22539168
Rotator cuff tear reduces muscle fiber specific force production and induces macrophage accumulation and autophagy.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society Dec, 2012 | Pubmed ID: 22696414
Hyaluronic acid, HAS1, and HAS2 are significantly upregulated during muscle hypertrophy.
American journal of physiology. Cell physiology Sep, 2012 | Pubmed ID: 22785117
Atrogin-1, MuRF-1, and sarcopenia.
Endocrine Feb, 2013 | Pubmed ID: 22815045
MMP inhibition as a potential method to augment the healing of skeletal muscle and tendon extracellular matrix.
Journal of applied physiology (Bethesda, Md. : 1985) Sep, 2013 | Pubmed ID: 23640595
Targeted inhibition of TGF-β results in an initial improvement but long term deficit in force production after contraction-induced skeletal muscle injury.
Journal of applied physiology (Bethesda, Md. : 1985) Jun, 2013 | Pubmed ID: 23766498
Aging-associated exacerbation in fatty degeneration and infiltration after rotator cuff tear.
Journal of shoulder and elbow surgery / American Shoulder and Elbow Surgeons ... [et al.] Jun, 2013 | Pubmed ID: 23790676
Changes in macrophage phenotype and induction of epithelial-to-mesenchymal transition genes following acute Achilles tenotomy and repair.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society Jul, 2014 | Pubmed ID: 24700411
Intrinsic stiffness of extracellular matrix increases with age in skeletal muscles of mice.
Journal of applied physiology (Bethesda, Md. : 1985) Aug, 2014 | Pubmed ID: 24994884
Simvastatin reduces fibrosis and protects against muscle weakness after massive rotator cuff tear.
Journal of shoulder and elbow surgery / American Shoulder and Elbow Surgeons ... [et al.] Feb, 2015 | Pubmed ID: 25213828
Inhibition of 5-LOX, COX-1, and COX-2 increases tendon healing and reduces muscle fibrosis and lipid accumulation after rotator cuff repair.
The American journal of sports medicine Dec, 2014 | Pubmed ID: 25245131
Synergist ablation induces rapid tendon growth through the synthesis of a neotendon matrix.
Journal of applied physiology (Bethesda, Md. : 1985) Dec, 2014 | Pubmed ID: 25277742
TGF-β superfamily signaling in muscle and tendon adaptation to resistance exercise.
Exercise and sport sciences reviews Apr, 2015 | Pubmed ID: 25607281
Changes in skeletal muscle and tendon structure and function following genetic inactivation of myostatin in rats.
The Journal of physiology Apr, 2015 | Pubmed ID: 25640143
p38 MAPK signaling in postnatal tendon growth and remodeling.
PloS one , 2015 | Pubmed ID: 25768932
Haploinsufficiency of myostatin protects against aging-related declines in muscle function and enhances the longevity of mice.
Aging cell Mar, 2015 | Pubmed ID: 25808276
Stuart M. Roche1,
Jonathan P. Gumucio1,2,
Susan V. Brooks2,3,
Christopher L. Mendias1,2,
Dennis R. Claflin3,4
1Department of Orthopaedic Surgery, University of Michigan Medical School,
2Department of Molecular & Integrative Physiology, University of Michigan Medical School,
3Department of Biomedical Engineering, University of Michigan Medical School,
4Department of Surgery, Section of Plastic Surgery, University of Michigan Medical School