Division of Diabetes,
Endocrinology and Metabolism,
Department of Medicine,
Division of Diabetes, Endocrinology and Metabolism, Department of Medicine
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Intraislet endothelial cells contribute to revascularization of transplanted pancreatic islets.
Diabetes May, 2004 | Pubmed ID: 15111502
Enhanced expression of VEGF-A in β cells increases endothelial cell number but impairs islet morphogenesis and β cell proliferation.
Developmental biology Jul, 2012 | Pubmed ID: 22546694
Islet microenvironment, modulated by vascular endothelial growth factor-A signaling, promotes β cell regeneration.
Cell metabolism Mar, 2014 | Pubmed ID: 24561261
Human islet preparations distributed for research exhibit a variety of insulin-secretory profiles.
American journal of physiology. Endocrinology and metabolism Apr, 2015 | Pubmed ID: 25648831
Stress-impaired transcription factor expression and insulin secretion in transplanted human islets.
The Journal of clinical investigation May, 2016 | Pubmed ID: 27064285
Development of a reliable automated screening system to identify small molecules and biologics that promote human β-cell regeneration.
American journal of physiology. Endocrinology and metabolism Nov, 2016 | Pubmed ID: 27624103
α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.
Cell reports Mar, 2018 | Pubmed ID: 29514095
Cystic fibrosis-related diabetes is caused by islet loss and inflammation.
JCI insight Apr, 2018 | Pubmed ID: 29669939
Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis.
Cell metabolism Mar, 2019 | Pubmed ID: 30449685
Human islets expressing HNF1A variant have defective β cell transcriptional regulatory networks.
The Journal of clinical investigation Jan, 2019 | Pubmed ID: 30507613
Tacrolimus- and sirolimus-induced human β cell dysfunction is reversible and preventable.
JCI insight Jan, 2020 | Pubmed ID: 31941840
Integrated human pseudoislet system and microfluidic platform demonstrate differences in GPCR signaling in islet cells.
JCI insight May, 2020 | Pubmed ID: 32352931
SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells.
Cell metabolism Dec, 2020 | Pubmed ID: 33207245
Coordinated interactions between endothelial cells and macrophages in the islet microenvironment promote β cell regeneration.
NPJ Regenerative medicine Apr, 2021 | Pubmed ID: 33824346
Combinatorial transcription factor profiles predict mature and functional human islet α and β cells.
JCI insight Sep, 2021 | Pubmed ID: 34428183
Integrated Analysis of the Pancreas and Islets Reveals Unexpected Findings in Human Male With Type 1 Diabetes.
Journal of the Endocrine Society Dec, 2021 | Pubmed ID: 34870058
Human pancreatic capillaries and nerve fibers persist in type 1 diabetes despite beta cell loss.
American journal of physiology. Endocrinology and metabolism Mar, 2023 | Pubmed ID: 36696598
Exocrine pancreas in type 1 and type 2 diabetes: different patterns of fibrosis, metaplasia, angiopathy, and adiposity.
Diabetes Oct, 2023 | Pubmed ID: 37881846
Tiffany M. Richardson*,1,
Yasminye D. Pettway*,1,
John T. Walker1,
Heather A. Nelson2,
Matthew Ishahak3,
Gregory Poffenberger2,
Radhika Aramandla2,
Conrad Reihsmann2,
Ashutosh Agarwal3,
Alvin C. Powers1,2,4,
Marcela Brissova2
1Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine,
2Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center,
3Department of Biomedical Engineering, University of Miami,
4, VA Tennessee Valley Healthcare System