Department of Neurology
Dr. Rutkove is Professor of Neurology, Harvard Medical School and serves as the Nancy Lurie Marks Chair of the Department of Neurology at Beth Israel Deaconess Medical Center. With extensive funding support from NIH, Dr. Rutkove’s medical research focuses on the application of innovative clinical neurophysiological techniques for the assessment and treatment of neuromuscular disorders and muscle dysfunction with an emphasis on electrical impedance methods. His research efforts have also included the impact of reduced gravity on musculoskeletal health, with past and ongoing support from NASA. An investigator with over 200 publications, he has recently served as an associate editor for Annals of Neurology. In 2011, he was awarded the Biomarker Challenge Prize from the non-profit foundation Prize4Life, Inc for his work demonstrating that electrical impedance measurements of muscle could speed clinical therapeutic studies in amyotrophic lateral sclerosis. In 2019, he also received the prestigious Herman P. Schwan International Award in Electrical Bioimpedance and in 2021, the Innovation Award from the American Association of Neuromuscular and Electrodiagnostic Medicine. These research efforts have led to the creation of two start-up companies, Haystack, Inc and Haystack Diagnostics, Inc, both focused on advancing neuromuscular diagnosis. His research efforts have recently been taking him into new directions, including the development of novel small-molecule and other therapies for the treatment of primary muscle and nerve disorders.
Electrical impedance myography: Background, current state, and future directions.
Muscle & nerve Dec, 2009 | Pubmed ID: 19768754
Characterizing spinal muscular atrophy with electrical impedance myography.
Muscle & nerve Dec, 2010 | Pubmed ID: 21104866
Electrical impedance myography in spinal muscular atrophy: a longitudinal study.
Muscle & nerve May, 2012 | Pubmed ID: 22499089
Electrical impedance myography as a biomarker to assess ALS progression.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases Sep, 2012 | Pubmed ID: 22670883
Machine learning algorithms to classify spinal muscular atrophy subtypes.
Neurology Jul, 2012 | Pubmed ID: 22786588
Cross-sectional evaluation of electrical impedance myography and quantitative ultrasound for the assessment of Duchenne muscular dystrophy in a clinical trial setting.
Pediatric neurology Jul, 2014 | Pubmed ID: 24814059
Optimizing electrical impedance myography measurements by using a multifrequency ratio: a study in Duchenne muscular dystrophy.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Jan, 2015 | Pubmed ID: 24929900
Composite biomarkers for assessing Duchenne muscular dystrophy: an initial assessment.
Pediatric neurology Feb, 2015 | Pubmed ID: 25447928
Inter-session reliability of electrical impedance myography in children in a clinical trial setting.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Sep, 2015 | Pubmed ID: 25533276
Clinical Measures of Disease Progression in Amyotrophic Lateral Sclerosis.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics Apr, 2015 | Pubmed ID: 25582382
Tongue electrical impedance in amyotrophic lateral sclerosis modeled using the finite element method.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Mar, 2016 | Pubmed ID: 26750579
Electrical Impedance Myography and Its Applications in Neuromuscular Disorders.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 01, 2017 | Pubmed ID: 27812921
Loss of electrical anisotropy is an unrecognized feature of dystrophic muscle that may serve as a convenient index of disease status.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Dec, 2016 | Pubmed ID: 27825055
A new technology, a new application, and the road ahead.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 02, 2017 | Pubmed ID: 28065594
Present Uses, Future Applications, and Technical Underpinnings of Electrical Impedance Myography.
Current neurology and neuroscience reports Sep, 2017 | Pubmed ID: 28933017
A novel partial gravity ground-based analog for rats via quadrupedal unloading.
Journal of applied physiology (Bethesda, Md. : 1985) Jul, 2018 | Pubmed ID: 29565773
Exploring the relationship between electrical impedance myography and quantitative ultrasound parameters in Duchenne muscular dystrophy.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Apr, 2019 | Pubmed ID: 30772764
Quantitative ultrasound of muscle can detect corticosteroid effects.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 08, 2019 | Pubmed ID: 31122815
Longitudinal time course of muscle impairments during partial weight-bearing in rats.
NPJ microgravity , 2019 | Pubmed ID: 31453318
Electrical impedance myography as a biomarker of inclusion body myositis: A cross-sectional study.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 02, 2020 | Pubmed ID: 31865137
Partial Weight-Bearing in Female Rats: Proof of Concept in a Martian-Gravity Analog.
Frontiers in physiology , 2020 | Pubmed ID: 32308630
Corrigendum: Partial Weight-Bearing in Female Rats: Proof of Concept in a Martian-Gravity Analog.
Frontiers in physiology , 2020 | Pubmed ID: 32719610
Using Electrical Impedance Myography as a Biomarker of Muscle Deconditioning in Rats Exposed to Micro- and Partial-Gravity Analogs.
Frontiers in physiology , 2020 | Pubmed ID: 33041858
Putting the patient first: The validity and value of surface-based electrical impedance myography techniques.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 07, 2021 | Pubmed ID: 33896693
Hindlimb suspension in Wistar rats: Sex-based differences in muscle response.
Physiological reports 10, 2021 | Pubmed ID: 34612585
Altered electrical properties in skeletal muscle of mice with glycogen storage disease type II.
Scientific reports 03, 2022 | Pubmed ID: 35351934