Department of Biological Sciences
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Involvement of hepatic glucocorticoid receptor-mediated functions in steroid-induced cataract formation.
Experimental eye research Nov, 2003 | Pubmed ID: 14550399
The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2008 | Pubmed ID: 18162536
Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2008 | Pubmed ID: 18182484
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.
Molecular brain , 2008 | Pubmed ID: 19021916
Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity.
Nature genetics Mar, 2009 | Pubmed ID: 19182805
Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models.
Nature chemical biology Sep, 2009 | Pubmed ID: 19597508
Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models.
Disease models & mechanisms Mar-Apr, 2010 | Pubmed ID: 20038714
C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease.
Developmental dynamics : an official publication of the American Association of Anatomists May, 2010 | Pubmed ID: 20108318
Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models.
Human molecular genetics Oct, 2011 | Pubmed ID: 21768216
Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast.
Science (New York, N.Y.) Dec, 2011 | Pubmed ID: 22033521