Takeshi Senga

Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration.

Possible activation of the renin-angiotensin system in the feto-placental unit in preeclampsia.

Repair by Src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine.

Hyaluronan-CD44s signaling regulates matrix metalloproteinase-2 secretion in a human lung carcinoma cell line QG90.

LSSIG is a novel murine leukocyte-specific GPCR that is induced by the activation of STAT3.

Stat3-dependent induction of BATF in M1 mouse myeloid leukemia cells.

Profiling of gene expression associated with hepatolithiasis by complementary DNA expression array.

A role for SHPS-1/SIRPalpha1 in IL-1beta- and TNFalpha-dependent signaling.

Cysteine residues in the C-terminal lobe of Src: their role in the suppression of the Src kinase.

Secretion of matrix metalloproteinase-9 by the proinflammatory cytokine, IL-1beta: a role for the dual signalling pathways, Akt and Erk.

SH2 domain containing protein tyrosine phosphatase 2 regulates concanavalin A-dependent secretion and activation of matrix metalloproteinase 2 via the extracellular signal-regulated kinase and p38 pathways.

Stat3-dependent induction of interleukin-3 receptor expression in leukemia inhibitory factor-stimulated M1 mouse leukemia cells.

Tyrosine phosphorylation of NOS3 in a breast cancer cell line and Src-transformed cells.

A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition.

A role for PI3K-Akt signaling in pulmonary metastatic nodule formation of the osteosarcoma cell line, LM8.

PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination.

A role for focal adhesion kinase signaling in tumor necrosis factor-alpha-dependent matrix metalloproteinase-9 production in a cholangiocarcinoma cell line, CCKS1.

SHP-2-Erk signaling regulates concanavalin A-dependent production of TIMP-2.

FAK signaling in neoplastic disorders: a linkage between inflammation and cancer.

SIRPalpha1 and SIRPalpha2: their role as tumor suppressors in breast carcinoma cells.

Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication.

A role for SHPS-1/SIRPalpha in Concanavalin A-dependent production of MMP-9.

Nek2 as an effective target for inhibition of tumorigenic growth and peritoneal dissemination of cholangiocarcinoma.

The cysteine-cluster motif of c-Src: its role for the heavy metal-mediated activation of kinase.

MEK inhibitor enhances the inhibitory effect of imatinib on pancreatic cancer cell growth.

The cysteine-cluster motif of c-Yes, Lyn and FAK as a suppressive module for the kinases.

Nek2 as a novel molecular target for the treatment of breast carcinoma.

A role for AP-1 in matrix metalloproteinase production and invadopodia formation of v-Crk-transformed cells.

Characterization of interaction between CLP36 and palladin.

Phosphorylation of histone H3 at Ser10: its role in cell transformation by v-Src.

Human papillomavirus type 16 oncoprotein E7 suppresses cadherin-mediated cell adhesion via ERK and AP-1 signaling.

Gene silencing of glypican-3 in clear cell carcinoma of the ovary renders it more sensitive to the apoptotic agent paclitaxel in vitro and in vivo.

Three-dimensional cell culture array using magnetic force-based cell patterning for analysis of invasive capacity of BALB/3T3/v-src.

S-nitrosylation at cysteine 498 of c-Src tyrosine kinase regulates nitric oxide-mediated cell invasion.

Novel combination treatment for colorectal cancer using Nek2 siRNA and cisplatin.

Silencing of Tousled-like kinase 1 sensitizes cholangiocarcinoma cells to cisplatin-induced apoptosis.

Cas utilizes Nck2 to activate Cdc42 and regulate cell polarization during cell migration in response to wound healing.

PI3K/Akt signaling is involved in the disruption of gap junctional communication caused by v-Src and TNF-α.

The roles of two distinct regions of PINCH-1 in the regulation of cell attachment and spreading.

Disruption of cell spreading by the activation of MEK/ERK pathway is dependent on AP-1 activity.

FLT3/ ITD regulates leukaemia cell adhesion through α4β1 integrin and Pyk2 signalling.

Recovery of anoikis in Src-transformed cells and human breast carcinoma cells by restoration of the SIRP α1/SHP-2 signaling system.

ARHGAP18, a GTPase-activating protein for RhoA, controls cell shape, spreading, and motility.

The loss of endoglin promotes the invasion of extravillous trophoblasts.

Role of palladin phosphorylation by extracellular signal-regulated kinase in cell migration.

Misshapen-like kinase 1 (MINK1) is a novel component of striatin-interacting phosphatase and kinase (STRIPAK) and is required for the completion of cytokinesis.

Plant lectin can target receptors containing sialic acid, exemplified by podoplanin, to inhibit transformed cell growth and migration.

S100A10 is required for the organization of actin stress fibers and promotion of cell spreading.

ALX1 induces snail expression to promote epithelial-to-mesenchymal transition and invasion of ovarian cancer cells.

The expression and characterization of endoglin in uterine leiomyosarcoma.

The Aurora-B-mediated phosphorylation of SHCBP1 regulates cytokinetic furrow ingression.

The role of PLK1-phosphorylated SVIL in myosin II activation and cytokinetic furrowing.

Peptide-based inhibition of the HOXA9/PBX interaction retards the growth of human meningioma.

Silencing of TBC1D15 promotes RhoA activation and membrane blebbing.

Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation.

B7-H4 overexpression correlates with a poor prognosis for cervical cancer patients.

PLAGL2 regulates actin cytoskeletal architecture and cell migration.

Expression of the miR200 family of microRNAs in mesothelial cells suppresses the dissemination of ovarian cancer cells.

GPC3 expression in mouse ovarian cancer induces GPC3‑specific T cell-mediated immune response through M1 macrophages and suppresses tumor growth.

Silencing of STRN4 suppresses the malignant characteristics of cancer cells.

Inhibition of SNW1 association with spliceosomal proteins promotes apoptosis in breast cancer cells.

SHCBP1 is required for midbody organization and cytokinesis completion.

Paired related homeobox 1 is associated with the invasive properties of glioblastoma cells.

Special AT-rich sequence-binding protein 2 suppresses invadopodia formation in HCT116 cells via palladin inhibition.

Plasma-activated medium suppresses choroidal neovascularization in mice: a new therapeutic concept for age-related macular degeneration.

SATB2 suppresses the progression of colorectal cancer cells via inactivation of MEK5/ERK5 signaling.

YAP is essential for tissue tension to ensure vertebrate 3D body shape.

EML4 promotes the loading of NUDC to the spindle for mitotic progression.

HOXB13 and ALX4 induce SLUG expression for the promotion of EMT and cell invasion in ovarian cancer cells.

Activation of Yes-Associated Protein in Low-Grade Meningiomas Is Regulated by Merlin, Cell Density, and Extracellular Matrix Stiffness.

UBE2S is associated with malignant characteristics of breast cancer cells.

Arginine methylation of ubiquitin-associated protein 2-like is required for the accurate distribution of chromosomes.

FAM98A is a novel substrate of PRMT1 required for tumor cell migration, invasion, and colony formation.

Treatment with near-infrared radiation promotes apoptosis in pancreatic cancer cells.

SATB1 and SATB2 play opposing roles in c-Myc expression and progression of colorectal cancer.

CAR T Cells Targeting Podoplanin Reduce Orthotopic Glioblastomas in Mouse Brains.

Erratum to: UBE2S is associated with malignant characteristics of breast cancer cells.

Erratum to: FAM98A is a novel substrate of PRMT1 required for tumor cell migration, invasion and colony formation.

α-Bisabolol Inhibits Invasiveness and Motility in Pancreatic Cancer Through KISS1R Activation.

Nek2 siRNA therapy using a portal venous port-catheter system for liver metastasis in pancreatic cancer.

A regulatory subunit of protein phosphatase 2A, PPP2R5E, regulates the abundance of microtubule crosslinking factor 1.

An immuno-wall microdevice exhibits rapid and sensitive detection of IDH1-R132H mutation specific to grade II and III gliomas.