Wolfgang Wurst

Novel allele of crybb2 in the mouse and its expression in the brain.

Activation of ERK/MAPK in the lateral amygdala of the mouse is required for acquisition of a fear-potentiated startle response.

Novel caspase-suicide proteins for tamoxifen-inducible apoptosis.

Pleiotropic effects in Eya3 knockout mice.

Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import.

Mitochondrial glutathione peroxidase 4 disruption causes male infertility.

Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes.

Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine.

Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice.

The specific role of histone deacetylase 2 in adult neurogenesis.

Central deficiency of corticotropin-releasing hormone receptor type 1 (CRH-R1) abolishes effects of CRH on NREM but not on REM sleep in mice.

Phenotypic annotation of the mouse X chromosome.

CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice.

Gene knockdown in the mouse through RNAi.

Mouse phenotyping.

Constitutive and conditional RNAi transgenesis in mice.

A powerful transgenic tool for fate mapping and functional analysis of newly generated neurons.

Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling.

Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice.

Forebrain CRF₁ modulates early-life stress-programmed cognitive deficits.

Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking.

Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb.

Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans.

MAPK signaling determines anxiety in the juvenile mouse brain but depression-like behavior in adults.

Cardiopulmonary dysfunction in the Osteogenesis imperfecta mouse model Aga2 and human patients are caused by bone-independent mechanisms.

Voluntary wheel running in mice increases the rate of neurogenesis without affecting anxiety-related behaviour in single tests.

Innovations in phenotyping of mouse models in the German Mouse Clinic.

In vitro analysis of bone phenotypes in Col1a1 and Jagged1 mutant mice using a standardized osteoblast cell culture system.

Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides.

High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner.

Expression analysis of Lrrk1, Lrrk2 and Lrrk2 splice variants in mice.

Rapamycin extends murine lifespan but has limited effects on aging.

Highly efficient targeted mutagenesis in mice using TALENs.

Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA.

An RNAi-based approach to down-regulate a gene family in vivo.

Wnt1-regulated genetic networks in midbrain dopaminergic neuron development.

Efficient isolation of pure and functional mitochondria from mouse tissues using automated tissue disruption and enrichment with anti-TOM22 magnetic beads.

Generation of targeted mouse mutants by embryo microinjection of TALENs.

Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon.

A robust and reliable non-invasive test for stress responsivity in mice.

High-throughput phenotypic assessment of cardiac physiology in four commonly used inbred mouse strains.

Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments.

Pleiotropic functions for transcription factor zscan10.

Mouse IDGenes: a reference database for genetic interactions in the developing mouse brain.

Creation of targeted genomic deletions using TALEN or CRISPR/Cas nuclease pairs in one-cell mouse embryos.

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.

Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility.

A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice.

MIM-Induced Membrane Bending Promotes Dendritic Spine Initiation.

Design and Generation of Gene-Targeting Vectors.

Development of an intein-mediated split-Cas9 system for gene therapy.

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

Beyond knockouts: the International Knockout Mouse Consortium delivers modular and evolving tools for investigating mammalian genes.

Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif.

Dickkopf 3 Promotes the Differentiation of a Rostrolateral Midbrain Dopaminergic Neuronal Subset In Vivo and from Pluripotent Stem Cells In Vitro in the Mouse.

Genome Editing in Mice Using TALE Nucleases.

Conditional Reduction of Adult Born Doublecortin-Positive Neurons Reversibly Impairs Selective Behaviors.

Assessing Cognition in Mice.

Differences in the spatiotemporal expression and epistatic gene regulation of the mesodiencephalic dopaminergic precursor marker PITX3 during chicken and mouse development.

Diet-induced and mono-genetic obesity alter volatile organic compound signature in mice.

Diversity matters - heterogeneity of dopaminergic neurons in the ventral mesencephalon and its relation to Parkinson's Disease.

CRFR1 in AgRP Neurons Modulates Sympathetic Nervous System Activity to Adapt to Cold Stress and Fasting.

Animal Models Are Valid to Uncover Disease Mechanisms.

Viable Ednra (Y129F) mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation.

Caspase-mediated apoptosis induction in zebrafish cerebellar Purkinje neurons.

The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.

Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice.

Interplay between H1 and HMGN epigenetically regulates OLIG1&2 expression and oligodendrocyte differentiation.

Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis.

Gene editing in mouse zygotes using the CRISPR/Cas9 system.

Control of gene editing by manipulation of DNA repair mechanisms.

Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss.

The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.

The pathogenic LRRK2 R1441C mutation induces specific deficits modeling the prodromal phase of Parkinson's disease in the mouse.

Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.

Fgf9 Mutation Alters Information Processing and Social Memory in Mice.

Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice.

Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic.

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.

Heterozygosity for the Mood Disorder-Associated Variant Gln460Arg Alters P2X7 Receptor Function and Sleep Quality.

Lifetime study in mice after acute low-dose ionizing radiation: a multifactorial study with special focus on cataract risk.

Identification of genetic elements in metabolism by high-throughput mouse phenotyping.

Laboratory mouse housing conditions can be improved using common environmental enrichment without compromising data.

Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy.

The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.

A mouse model for intellectual disability caused by mutations in the X-linked 2'‑O‑methyltransferase Ftsj1 gene.