Department of Medicine
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IL-4 suppresses very late antigen-4 expression which is required for therapeutic Th1 T-cell trafficking into tumors.
Journal of immunotherapy (Hagerstown, Md. : 1997) Oct, 2009 | Pubmed ID: 19752754
Intralesional delivery of dendritic cells engineered to express T-bet promotes protective type 1 immunity and the normalization of the tumor microenvironment.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2010 | Pubmed ID: 20675595
Therapeutic effectiveness of intratumorally delivered dendritic cells engineered to express the pro-inflammatory cytokine, interleukin (IL)-32.
Cancer gene therapy Sep, 2011 | Pubmed ID: 21760628
Combined Tbet and IL12 gene therapy elicits and recruits superior antitumor immunity in vivo.
Molecular therapy : the journal of the American Society of Gene Therapy Mar, 2012 | Pubmed ID: 22215017
Extranodal induction of therapeutic immunity in the tumor microenvironment after intratumoral delivery of Tbet gene-modified dendritic cells.
Cancer gene therapy Aug, 2013 | Pubmed ID: 23846252
Comparable Genital Tract Infection, Pathology, and Immunity in Rhesus Macaques Inoculated with Wild-Type or Plasmid-Deficient Chlamydia trachomatis Serovar D.
Infection and immunity Oct, 2015 | Pubmed ID: 26216426
CD36 Provides Host Protection Against Klebsiella pneumoniae Intrapulmonary Infection by Enhancing Lipopolysaccharide Responsiveness and Macrophage Phagocytosis.
The Journal of infectious diseases Dec, 2016 | Pubmed ID: 27683817
Patient-Derived Airway Secretion Dissociation Technique To Isolate and Concentrate Immune Cells Using Closed-Loop Inertial Microfluidics.
Analytical chemistry May, 2017 | Pubmed ID: 28402103
A -Specific TCR-Transgenic Mouse Demonstrates Th1 Polyfunctionality with Enhanced Effector Function.
Journal of immunology (Baltimore, Md. : 1950) 10, 2017 | Pubmed ID: 28855311
Thrombospondin-1 protects against pathogen-induced lung injury by limiting extracellular matrix proteolysis.
JCI insight Feb, 2018 | Pubmed ID: 29415890
1Research Laboratory of Electronics, Massachusetts Institute of Technology,
2Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology,
3Department of Medicine, University of Pittsburgh,
4Department of Biological Engineering, Massachusetts Institute of Technology,
5Vascular Medicine Institute, University of Pittsburgh