Tracking Tumor Cell Dissemination from Lung Metastases Using PhotoconversionMadeline Friedman-DeLuca 1,2, Prachiben P. Patel 1,2, Burcu Karadal-Ferrena 1,2, Nicole D. Barth 1,2, Camille L. Duran 1,2, Xianjun Ye 1,2,3, Michael Papanicolaou 2,4, John S. Condeelis 2,3,4,5,6,7, Maja H. Oktay 1,2,3,5,6,7, Lucia Borriello *1,2,8, David Entenberg *1,2,3,5,6
1Department of Pathology, Albert Einstein College of Medicine/Montefiore Medical Center, 2Cancer Dormancy and Tumor Microenvironment Institute, Albert Einstein College of Medicine/Montefiore Medical Center, 3Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine/Montefiore Medical Center, 4Department of Cell Biology, Albert Einstein College of Medicine/Montefiore Medical Center, 5Montefiore Einstein Cancer Center, Albert Einstein College of Medicine/Montefiore Medical Center, 6Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine/Montefiore Medical Center, 7Department of Surgery, Albert Einstein College of Medicine/Montefiore Medical Center, 8Department of Cancer and Cellular Biology, Lewis Katz School of Medicine, Fox Chase Cancer Center
We present a method for studying tumor cell redissemination from lung metastases involving a surgical protocol for the selective photoconversion of lung metastases, followed by the identification of redisseminated tumor cells in tertiary organs.
