Biomarker Identification for Gender Specificity of Alzheimer's Disease Based on the Glial Transcriptome ProfilesHanjie Liu *1, Hui Yang *2, Shuqing Liu 1, Siyu Li 1, Wen Yang 3, Anwar Ayesha 1, Xin Tan 4, Cen Jiang 1, Yi Liu 5, Lushuang Xie 1
1Chengdu University of Traditional Chinese Medicine, 2Chengdu Shuangliu Hospital of Traditional Chinese Medicine, 3Department of Automation, Tsinghua University, 4Affiliated Reproductive & Women-Children Hospital, Chengdu University of Traditional Chinese Medicine, 5Department of Neurology, Dalian Municipal Central Hospital, Central Hospital of Dalian University of Technology
This study analyzed single-nuclei transcriptomes of thirty-three individuals with Alzheimer's disease (AD), revealing sex-specific DEGs in glial cells. Functional enrichment analysis highlighted synaptic, neural, and hormone-related pathways. Key genes, namely NLGN4Y and its regulators, were identified, and potential therapeutic candidates for gender-specific AD were proposed.
